Bad Bunny understood the assignment…

What do you think of the evidence of DNA methylation contributing causally to migraine risk from Liu et al.’s article in @ehfofficial.bsky.social’s J Headache Pain, also chosen as a #PRF #EditorsPick from David Finn? bit.ly/4iYYLyk

Big new paper from us published yesterday: The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain www.science.org/doi/10.1126/... Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane

The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain

Phosphorylation of hundreds of protein extracellular domains is mediated by two kinase families but the functional role of these kinases is underexplored. We find that the presynaptic release of the t...

science.org

🚨New paper from the NIH PRECISION Human Pain Network! We built a human DRG reference atlas: >500K cells from 126 donors to reveal 22 neuronal & 10 non-neuronal cell types. New insights into human sensory biology! Paper: biorxiv.org/content/10.1... Data: humandrg.painseq.com

HL60 cells take on so many fun shapes as they migrate! This #InsightFromImaging data features cells prepared by Leanna and imaged on the @aicjanelia.bsky.social LLSM by @cmhobson.bsky.social

Our team is hard at work preparing for #InsightFromImaging 2025! We can't wait to welcome HHMI #HannaGrayFellows to @hhmijanelia.bsky.social next week for lectures, hands-on labs, and activities focused on designing informative and quantitative bioimaging experiments 🔬

New method development work from our lab that I hope will make it easier for labs to work with peripheral nervous system tissues recovered from organ donors, tissue donors, and fast autopsies: www.biorxiv.org/content/10.1... This work was led by the amazing duo of Joe Lesnak and Mandee Schaub

I agree with this essay and it is why I don’t use AI for much of anything. I have this job because I enjoy thinking.

The Transmitter @thetransmitter.bsky.social · last yr.

“Competent prose generated by a machine, I’ve come to realize, might not be what science actually needs.” ? By Tim Requarth #neuroskyence www.thetransmitter.org/from-bench-t...

📢We're #hiring Group Leaders! Apply to lead a lab at Janelia & advance biology using theory, computational modeling & machine learning. 🔹5-year renewable appointment 🔹Pioneer new tools & approaches 🔹Collaborate across disciplines Apply by Nov. 4👉 https://janelia.link/groupleader

BOOM! Cool to see the final form of this great work now published. Deep new insight into human peripheral neuropathy. Congrats @mheming.bsky.social and colleagues on a great study.

@mheming.bsky.social · last yr.

Very proud that our human PNS atlas is finally published in @natcomms.nature.com We found perineurial hyperplasia and lipid-associated nerve macrophages in #polyneuropathies. Explore: pns-atlas.mzhlab.com A tweetorial 1/13 doi.org/10.1038/s414...

This work is finally online as in-press preview! JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...

Do you have any questions about the current understanding and treatment of #migraine? Check out the newest episode of the Pain Beat moderated by @julietmwirigi.bsky.social! bit.ly/3GGjCYu #podcast #newepisode #PRF

Some really great stuff in our new preprint on sympathetic ganglion in humans - confirmation of what I think many suspected on Nav1.7 expression in human sympathetic neurons.

Saad Yousuf PhD@saadyousuf.bsky.social · last yr.

Excited to share our preprint on spatial transcriptomics of human sympathetic chain ganglia and the effect of diabetes. We also compared sympathetic and dorsal root ganglia to identify ganglia-specific signatures. Work led by @marisolmancilla.bsky.social doi.org/10.1101/2025...

🌞 nice day for a workshop at #NAPainSchool with @tedpricethepainguy.bsky.social

We finally have an impact factor at Neurobiology of Pain. Thanks to our editorial team: Michael Burton, @annatheneurosci.bsky.social, and Dave Seminowicz; the editorial board; and all our wonderful authors for submitting such great papers over the past several years.

the wonders of GLP1 bump into migraine: www.nature.com/articles/d41...

Obesity drugs show promise for treating a new ailment: migraine

Liraglutide, a member of the family of blockbuster weight-loss drugs, reduces headaches by half in a small study.

nature.com

I’m so honored to be selected as both a 2025 McKnight Scholar and 2025 HHMI Freeman Hrabowski Scholar. And I couldn’t be prouder to share these honors with awesome @ucdavis.bsky.social colleagues 💙💛💙💛 health.ucdavis.edu/news/headlin...

UC Davis researchers honored by McKnight and Howard Hughes Medical Institute

UC Davis faculty Sergey Stavisky, Theanne Griffith and Elisa Zhang receive prestigious early-career recognition from McKnight Endowment Fund and the Howard Hughes Medical Institute.

health.ucdavis.edu

Loved this interview from the legendary Eve Marder. I agree when she said many papers today are so poorly written that they are unreadable. And our trainees writing is not good because people dont read anymore; not just science reading, but any book in any genre.

The Night Science Podcast@nightsciencepod.bsky.social · last yr.

🔥 New episode of the Night Science podcast! The brilliant Eve Marder, professor at Brandeis University, talks with us about how "Recipe Science" ruins creativity. Apple: podcasts.apple.com/us/podcast/n... Spotify: open.spotify.com/episode/4mSv...

If you love satellite glial cells (SGCs) then you have got to read about Ole Ahlgreen's great work, part of which was done while he was a visiting PhD student in our lab: www.biorxiv.org/content/10.1...

Mapping satellite glial cell heterogeneity reveals distinct spatial organization and signifies functional diversity in the dorsal root ganglion

Satellite glial cells (SGCs) envelop the somata, axon hillock, and initial axon segment of sensory neurons in the dorsal root ganglia (DRG), playing a critical role in regulating the neuronal microenv...

biorxiv.org

First time we’ve had the honor of the @dallasmorningnews.bsky.social writing about our scientific discoveries, funded by the #NIH www.dallasnews.com/news/2025/05...

UTD scientists solve 100-year-old mystery behind diabetic nerve damage

Nageotte nodules, once overlooked, may hold the key to understanding and treating diabetic peripheral neuropathy.

dallasnews.com

people need to internalize, very quickly, that federal research grants are a hypercompetitive contracting process not charity, and that what Uncle Sam gets in return for that money is American dominance in the future

Congrats to the Kolber lab @utdpaincenter.bsky.social and especially Christian Fofie for his terrific work that made this paper come together. www.cell.com/cell-reports...

Profiling human iPSC-derived sensory neurons for analgesic drug screening using a multi-electrode array

Fofie et al. present a high-content screening platform using hiPSC-derived nociceptors cultured on multi-well multielectrode arrays to identify peripheral analgesics with diverse mechanisms of action....

cell.com

youtu.be/J25NJoe1B0g

The NIH HEAL Initiative–HEAL Is Hope

YouTube video by National Institutes of Health (NIH)

youtu.be

BOOM! www.nature.com/articles/s41... I think this is a big step forward for the field. Congrats to Lauren Donovan and @vivtawfik-mdphd.bsky.social and the whole Tawfik lab team.

Aging and injury drive neuronal senescence in the dorsal root ganglia - Nature Neuroscience

The authors describe a susceptibility of the peripheral nervous system to neuronal senescence with age or injury relevant for sensory dysfunction, such as chronic pain.

nature.com

Happening now: NINDS Council public meeting, including presentation of the #HEAL #painresearch recommendations videocast.nih.gov/livew.asp?li...

WOOHOOO!!!

Stephani Sutherland@sutherlandphd.bsky.social · last yr.

And it's unanimous! The NINDS Advisory Council has approved the HEAL pain research priority recommendations.

We wrote this Neuroview to get the word out about the extremely exciting and important NIH funded work happening in the pain field and how it has the potential to really change pain treatment in the coming years www.cell.com/neuron/fullt... We did not imagine how rapidly things would be dismantled.

Human pain neuroscience and the next generation of pain therapeutics

The recent approval of suzetrigine for acute pain treatment highlights both the success of targeting peripheral sensory neurons for pain management and the potential of developing new pain therapies p...

cell.com

This paper is now published in Nature Communications www.nature.com/articles/s41... Huge congrats to Stephanie Shiers on this magnum opus updating our view of Nageotte's legendary pathology work in the early 1900s.

Nageotte nodules in human dorsal root ganglia reveal neurodegeneration in diabetic peripheral neuropathy - Nature Communications

Nageotte nodules in the dorsal root ganglia were first described 100 years ago, but little is known about them. Here, the authors link Nageotte nodules to neurodegeneration in diabetic neuropathy in h...

nature.com

bioRxivpreprint@biorxivpreprint.bsky.social · 2y ago

Nageotte nodules in human DRG reveal neurodegeneration in painful diabetic neuropathy https://www.biorxiv.org/content/10.1101/2024.08.22.609215v1

Bravo, Kara! We desperately need scientists finding creative ways to connect with the public, explaining how science works and why it matters. Take @karalmarshall.bsky.social up on her offer, grab those slides, and find an audience that needs to hear this! #proudmentor

Kara Marshall@karalmarshall.bsky.social · last yr.

Gave a talk at my parents’ retirement community to describe how science is done, and what is at stake. There was a ton of interest, and anyone can do this. Get the word out about how science affects everyone. I’m happy to share slides with anyone who asks- just get in touch! youtu.be/BY_SFgi-Cig

The president is recommending a 40% cut to next year’s NIH budget. This would be disastrous for our nation’s health and economy. Please contact your representatives, especially if they are Republicans, and tell them why this cannot happen. An easy option: 5calls.org

5 Calls

Spend 5 minutes. Make 5 calls. Make your voice heard.

5calls.org

Richard Van Noorden@richvn.bsky.social · last yr.

Trump proposes unprecedented budget cuts for US science in next fiscal year NASA cut by 24% NIH cut by 40% EPA cut by 55% NSF cut by 56% Analysis from @maxkozlov.bsky.social @dangaristo.bsky.social @alexwitze.bsky.social and @nature.com team www.nature.com/articles/d41...