In case you missed it: A combination of experimental approaches reveals a comprehensive picture of delta opioid receptor pharmacology, which could help efforts towards better drug design, including for #migraine and #headache. migrainecollaborative.org/the-delta-op...

The Delta Opioid Receptor: New Insight into a Promising Target for Migraine and Pain Treatment - Migraine Science Collaborative

A combination of experimental approaches reveals a comprehensive picture of DOR pharmacology, which could help efforts towards better drug design.

migrainecollaborative.org

Instructor, Assistant, Associate, or Professor Pain Psychologist We have an excellent opportunity for a pain psychologist to join our interventional, multidisciplinary Pain Management Division, within the Department of Anesthesiology, Washington University, St. Louis. The mission of the Washington

Washington University Pain Center

Alleviate pain through research, education, and clinical practice. Discover how the Washington University Pain Center is dedicated to reducing human suffering.

pain.wustl.edu

Our NIAAA funded Post-DoctT32 has received its NoA (non competing renewal). Are you looking for a post-doc and interested in joining our amazing center? If so, reach out! Here is a convenient form that you can use to upload CV and a cover letter! unc.az1.qualtrics.com/jfe/form/SV_...

Our latest preprint. More evidence that diabetic neuropathy is a neuro degenerative disease. Very proud of @ish1789.bsky.social and our whole PRECISION group who made this work possible. #HEALinitiative funded

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 7mo ago

Progressive neurodegeneration in human dorsal root ganglion from diabetes to painful neuropathy https://www.biorxiv.org/content/10.64898/2026.01.16.700028v1

#NIHfunding via the HEAL initiative for the PRECISION Human Pain Network has yielded a massive increase in data on human sensory neurons. One of the most amazing collaborations I've been part of. Data sharing across 4 centers, insights from experts across the network that really moved the needle.

Ted Price@tedpricethepainguy.bsky.social · 9mo ago

The BIG DRG paper is now up on @biorxiv-neursci.bsky.social www.biorxiv.org/content/10.1... so many people worked so hard to make this happen. Props to the whole PRECISION Human Pain Network.

anesthesiology.wustl.edu/washu-medici...

WashU Medicine Anesthesiology shines at American Headache Society Meeting | Anesthesiology | Washington University School of Medicine in St. Louis

The Department of Anesthesiology at WashU Medicine showcased its leadership in migraine research at the 2025 American Headache Society Meeting with multiple podium presentations, featured sessions, an...

anesthesiology.wustl.edu

The end of an era as these 3 colleagues finish their tenure in the lab. Each the product of supportive programs to help them launch their journey and now off to med school, postdoc and grad school. Will miss you all but super excited for your future. Jakayla, Bobbie, Alexa - Go get em.

First time we’ve had the honor of the @dallasmorningnews.bsky.social writing about our scientific discoveries, funded by the #NIH www.dallasnews.com/news/2025/05...

UTD scientists solve 100-year-old mystery behind diabetic nerve damage

Nageotte nodules, once overlooked, may hold the key to understanding and treating diabetic peripheral neuropathy.

dallasnews.com

youtu.be/J25NJoe1B0g

The NIH HEAL Initiative–HEAL Is Hope

YouTube video by National Institutes of Health (NIH)

youtu.be

Excited to introduce Dr. Bobbie Brown, who happens to be our lab’s PhD #15. With co-mentor Bryan Copits.

Send good vibes to our colleagues at NIH folks.

BOOM! Human DRG patch-seq with Nav1.8 and Nav1.7 upregulation associated with a history pain in organ donors. www.biorxiv.org/content/10.1... Great stuff from the #PRECISIONPain Center at WashU led by @robgereau.bsky.social

Human sensory neurons exhibit cell-type-specific, pain-associated differences in intrinsic excitability and expression of SCN9A and SCN10A

Despite the prevalence of chronic pain, the approval of novel, non-opioid therapeutics has been slow. A major translational challenge in analgesic development is the difference in gene expression and ...

biorxiv.org

Science is under threat in the US. @elife.bsky.social have commissioned a series of articles discussing the implications and what we can do. The first three articles are now live. More to follow: elifesciences.org/articles/106... elifesciences.org/articles/106... elifesciences.org/articles/106...

Science Under Threat in the United States: How scientists and institutions should respond

Individual researchers and university leaders need to make the case for science to their elected representatives and to the public at large.

elifesciences.org

New work from the lab published at @cp-neuron.bsky.social. In this study we dissect the role of hormonal regulation in pain-induced enhanced opioid intake in males. Work conducted by the super talented @jessinbotham www.cell.com/neuron/fullt...

Estradiol protects against pain-facilitated fentanyl use via suppression of opioid-evoked dopamine activity in males

Higginbotham et al. show that inflammatory pain increases opioid-evoked dopamine neuron activity to promote fentanyl use selectively in males. Ovarian hormones offer females protection, but estradiol’...

cell.com

Opioids remain a common treatment for chronic pain — but at a cost. Now, scientists at WashU Medicine and Stanford University have developed a pain-relieving compound that mimics cannabis' benefits without the mind-altering side effects or risk of addiction. medicine.washu.edu/news/compoun...

Compound harnesses cannabis’ pain-relieving properties without side effects | WashU Medicine

Mouse study points to an effective alternative to opioids

medicine.washu.edu

Excited to present the result of a fantastic collaborative effort - funded by the National Institutes of Health, including the NIH HEAL Initiative, to develop safer analgesic drugs. www.nature.com/articles/s41...

A cryptic pocket in CB1 drives peripheral and functional selectivity - Nature

A peripherally restricted CB1 agonist (VIP36) targeting a cryptic receptor pocket was developed, showing high efficacy in mouse pain models with minimal side effects and tolerance, potentially revolut...

nature.com

a bit of good news - thak you @jeremymberg.bsky.social for all of the information and insights!

Jeremy Berg@jeremymberg.bsky.social · last yr.

Study Section meetings actually announced in the Federal Register today! www.federalregister.gov/documents/20...

NIH indirects case update: Hearing ongoing now, and I'll try to live tweet some notable exchanges. Prior to more detailed arguments, Judge Kelley starts off with a few point questions to both sides: (I'm paraphrasing here)

Check out the scientific journey behind the newest FDA-approved pain medication! 💊 Learn how NIH-funded research played a crucial role—both directly and indirectly—in bringing this breakthrough to life. 🧪

Jeremy Berg@jeremymberg.bsky.social · last yr.

I have been trying to find the time to move away from the polical hellscape we find ourselves in to finish and share a bluetorial about science. This helps me remember what this is all about. Ironically, it is about the treatment of pain.

Threats to science abound. It's been hard for everyone - but the energy in the lab today is incredible. Scientists brainstorming projects, pouring over exciting new data, companies vying to acquire licensing rights to patents we have for potential new #chronicpain treatments. So inspired by our team

🚨 SAVE THE DATE! 🚨 2nd edition of the St. Louis Translational Pain Research Forum! a joint effort between SLU, WashU and UHSP 🗓 Sept 26-27, 2025 🎤 Keynote: Dr. Cheryl Stucky 💡 Plenary: Dr. Patrick Dougherty Register now ->🔗 stl-tprf2023.my.canva.site/stl-tprf2025 #PainResearch #Neuroskyience

A big day for pain care, and for pain science. www.fda.gov/news-events/...

FDA Approves Novel Non-Opioid Treatment for Moderate to Severe Acute Pain

The FDA approved Journavx (suzetrigine) 50 mg oral tablets, a first-in-class non-opioid analgesic to treat moderate to severe acute pain in adults.

fda.gov

science-ing is amazing these days. www.nature.com/articles/s41...

Resolving native GABAA receptor structures from the human brain - Nature

Cryo-electron microscopy structures of native type A GABA receptors from human brain reveal diverse subunit compositions, protein binding partners and binding sites for antiepileptic drugs.

nature.com

I just reached out to my senators about the NIH situation. If you need to find out how much impact NIH has in your state in terms of dollars in and their economic impact here's a link: www.unitedformedicalresearch.org/nih-in-your-...

NIH In Your State - United For Medical Research

Select a state on the map to see the impact of NIH funding across America.

unitedformedicalresearch.org

Fantastic work here. A real boost to the KCC2 modulator concept, providing very encouraging validation in human subjects. Ted, Yves, Mike and teams!

Ted Price@tedpricethepainguy.bsky.social · 2y ago

Very excited to share our new preprint: "Decreased KCC2 expression in the human spinal dorsal horn associated with chronic pain and long-term opioid use" led by @oliviadavis.bsky.social and Samuel Ferland, a collab between us, Yves De Koninck and Mike Hildebrand labs www.biorxiv.org/content/10.1...

If you could only read one article about chronic pain read this #painresearch www.nytimes.com/2025/01/12/m...

Chronic Pain Afflicts Billions of People. It’s Time for a Revolution.

As many as two billion people suffer from it — including me. Can science finally bring us relief?

nytimes.com

There's our very own @julietmwirigi.bsky.social from @washumedicine.bsky.social and the WashU Pain Center.

HHMI@hhmi-science.bsky.social · 2y ago

Meet the newly named hashtag#HannaGrayFellows! 👋 “HHMI is committed to investing in scientists who dare to tackle some of the biggest challenges of our lifetime,” said HHMI Vice President and Chief Scientific Officer @leslievosshall.bsky.social