To have this paper appear the same day that RFK Jr is canceling all mRNA vaccine funding is further indication that irony is not dead, even though we might all be soon.
SARS‑CoV‑2 (COVID-19)@covid19disease.bsky.social · last yr.Andreas Carlström
@pelleeas.bsky.social
Postdoc in the lab of Martin Ott (@mitolab.bsky.social) studying regulation of mitochondrial gene expression.
SARS‑CoV‑2 (COVID-19)@covid19disease.bsky.social · last yr.
🚀 Excited to share our latest work on Mrx6 and mtDNA copy number regulation, now available on @biorxivpreprint.bsky.social ! We uncover how Mrx6 and Mam33 interact with the Lon protease Pim1 to control substrate degradation. 🔬 Check it out here: www.biorxiv.org/content/10.1... #mitochondria #mtDNA
Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number
Mitochondrial DNA (mtDNA) copy number regulation remains incompletely understood, despite its importance in cellular function. In Saccharomyces cerevisiae, Mrx6 belongs to the Pet20-domain-containing ...
biorxiv.org
In a new study by our @pelleeas.bsky.social, we reveal how Mrx4 organizes translational regulation of cytochrome b synthesis at the mitoribosomal tunnel exit. Thanks @kawresearch.bsky.social for funding and @stirlingchurchman.bsky.social for the fun collaboration! academic.oup.com/nar/article/...
A molecular switch at the yeast mitoribosomal tunnel exit controls cytochrome b synthesis
Abstract. Mitochondrial gene expression needs to be balanced with cytosolic translation to produce oxidative phosphorylation complexes. In yeast, translati
academic.oup.com
Identified in the 1970s, the precise molecular function of the alternative initiation factor eIF2A has remained unclear. Here, we map its interactome and uncover a surprising role in ribosome-associated quality control (RQC) upon ribosome stalling. 1/x www.biorxiv.org/content/10.1...
The alternative initiation factor eIF2A regulates 40S subunit turnover in ribosome-associated quality control
The noncanonical translation initiation factor eIF2A plays critical roles in diverse cellular processes, including the integrated stress response, neurodegeneration and tumorigenesis. However, the pre...
biorxiv.org