Osman Lab
@osman-lab.bsky.social
Studying the mysteries that surround the genome of the cell's powerhouse https://www.osman-lab.de
Interested to know how #mtHsp70 looks inside #mitochondria and what that means for #mitochondrial #proteostasis and #stress #signalling? Take a look at our latest publication in @pnas.org 🥳🥳 @osman-lab.bsky.social doi.org/10.1073/pnas...
Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]
Out now in @science.org Pearling drives mitochondrial DNA nucleoid distribution | Science www.science.org/doi/10.1126/...
Pearling drives mitochondrial DNA nucleoid distribution
The distribution of mitochondrial DNA–containing nucleoids is essential for mitochondrial function and genome inheritance; however, no known mechanisms can explain nucleoid segregation or their regula...
science.org
What are the roles of UFMylation during ribosome-associated quality control? @gekaragoz.bsky.social @plantophagy.bsky.social and colleagues find it to cooperate with RQC factors in promoting clearance of arrested nascent polypeptides at the ER link.springer.com/article/10.1...
The coordinated action of UFMylation and the RQC pathways clears arrested polypeptides at the ER - The EMBO Journal
Clearance of arrested nascent polypeptides resulting from ribosomal stalling is essential for proteostasis. Stalled endoplasmic reticulum (ER)-bound ribosomes are marked by ubiquitin-fold modifier 1 (...
link.springer.com
Congrats Milica @alessandrick.bsky.social & everyone @gekaragoz.bsky.social lab. Glad we could contribute to this awesome story on #UFMylation & #RQC crosstalk @embojournal.org link.springer.com/article/10.1...
The coordinated action of UFMylation and the RQC pathways clears arrested polypeptides at the ER - The EMBO Journal
Clearance of arrested nascent polypeptides resulting from ribosomal stalling is essential for proteostasis. Stalled endoplasmic reticulum (ER)-bound ribosomes are marked by ubiquitin-fold modifier 1 (...
link.springer.com
Our work on the role of Ufmylation on ribosome quality control on the ER is out! Great work of two terrific first authors Milica and @alessandrick.bsky.social together with our wonderful collaborators, the one and only Dagdas lab @plantophagy.bsky.social!
Max Perutz Labs Vienna@maxperutzlabs.ac.at · 4mo ago🆕 publication! The @gekaragoz.bsky.social lab shows how cells clear stalled ribosomes at the ER, preventing harmful 'traffic jams' during protein synthesis🚦Their new @embojournal.org study reveals how quality control and UFMylation team up to keep translation moving ➡️ tinyurl.com/2czj8fvp
Emerging mechanisms of genome degradation during the mtDNA life cycle www.nature.com/articles/s41...
Emerging mechanisms of genome degradation during the mtDNA life cycle - Nature Cell Biology
Mitochondrial DNA (mtDNA) is not static but undergoes a regulated ‘life cycle’ that encompasses replication, maintenance, spatial distribution and turnover. Here, we update emerging mtDNA degradative ...
nature.com
The New Phytologist Foundation is pleased to sponsor the 39th Molecular Biology of Plants Conference! The conference takes place in Hennef, Germany, this week. www.pflanzen-molekularbiologie.de/conference-m... @molplantsci.bsky.social #PlantScience #MBP2026
Conference
Conference "Molecular Biology of Plants" - Annual meeting of the Section Plant Physiology and Molecular Biology in the German Society for Plant Sciences (DBG)
pflanzen-molekularbiologie.de
We have officially launched our new lab website. 🥳 The site includes the automated literature curation on #mtDNA quality control and copy number regulation, which will appear on Mondays and Thursdays. Listen to the latest #NotebookLM generated podcast. 🧬 Explore the new site: osman-lab.de
The Osman Lab | LMU Munich
Mitochondrial research and genome maintenance at Ludwig-Maximilians-University.
osman-lab.de
Daily #mtDNA intel: • AK4-mediated synthesis fuels macrophage immunity 🧬 • T cell mutations found post-chemotherapy • Osteomodulin suppresses osteoclast respiration 🔬 #genetics 📄 Full Dossier | 🎙️ Podcast
Daily #mtDNA intel: • Structural partitioning improves phylogenetic signals 🧬 • Transmembrane helices show conserved thymine/hydrophobic bias 🔬 • New #nematode mitogenome data. 📄 Full Dossier | 🎙️ Podcast
Daily #mtDNA intel: • PS1 in inner membrane regulates cristae & mtDNA stability 🧬 • MitoMetrics refines forensic likelihood ratios • SMC loss linked to MELAS dysmotility 🔬 #Genetics 📄 Full Dossier | 🎙️ Podcast
Daily #mtDNA intel: • Most axonal mitochondria lack mtDNA/ATP 🧬 • ROS impairs lysosomal flux in human APOE4 cells • Mitogenome variants impact Parkinson's progression 🔬 #Neuro 📄 Full Dossier | 🎙️ Podcast
Daily #mtDNA intel: • Fumarate loss activates cGAS-STING 🧬 • MT-CO2 m.8024G>A drives bioenergetic failure • mtDNA background impacts pS65-Ub in Lewy body disease 🔬 #genetics 📄 Full Dossier | 🎙️ Podcast
Daily #mtDNA intel: • C24-Ceramide-VDAC1 binding triggers hypoxic mtDNA release 🧬 • TFAM roles mapped across pan-cancer types • Melatonin identified as a mitochondrial radioprotectant 🔬 📄 Full Dossier | 🎙️ Podcast
Daily #mtDNA intel: • Liver mitochondria drive systemic inter-organ aging 🧬 • cGAS-STING blockade preserves tendon stem cell fitness • ZBP1 promotes RIPK1-dependent apoptosis 📄 Full Dossier | 🎙️ Podcast
#C.elegans is about to join the 'centriolar satellites' club. Check out our new preprint #centriolarsatellites: www.biorxiv.org/content/10.6...
Daily #mtDNA intel: • MAF1 inhibits AIM2 by sequestering host mtDNA 🧬 • Cytoskeleton loss dysfunctions B-ALL mitochondria • LRRK2 G2019S drives oxidative DNA damage 🔬 #CellBio #Genetics 📄 Full Dossier | 🎙️ Podcast
New online: Stress adaptation of mitochondrial protein import by OMA1-mediated degradation of DNAJC15
Stress adaptation of mitochondrial protein import by OMA1-mediated degradation of DNAJC15
Nature Structural & Molecular Biology, Published online: 27 February 2026; doi:10.1038/s41594-026-01756-0Kroczek et al show that degradation of DNAJC15 by OMA1 and AFG3L2 under stress limits mitochondrial protein import and OXPHOS biogenesis. Non-imported proteins lead to the induction of the unfolded protein responses from the endoplasmic reticulum.
dlvr.it
Daily #mtDNA intel: • APOL3 mediates mtDNA efflux via lysosomal damage • ALS blood/CSF mtDNA indices profiled 🧬 • CRISPR-guided biogenesis in iPSC-CMs 🔬 📄 Full Dossier | 🎙️ Podcast
Daily #mtDNA intel: • TFAM replication vital for oocyte competence 🧬 • Hypoxia triggers APOBEC3A-mediated DNA damage • Aging reduces muscle resilience after disuse #MitoSci 📄 Full Dossier | 🎙️ Podcast
Daily #mtDNA intel: • PRMT5 regulates stability via TFAM methylation 🧬 • Leakage triggers cGAS-STING neuroinflammation • Mitophagy failure promotes release in selenium deficiency 🔬 📄 Full Dossier | 🎙️ Podcast
Daily #mtDNA intel: • 4,5-DHA validated as robust disease marker • Single-cell lineage tracing via inheritance modeling • ROS quenching suppresses cGAS-STING signaling 🧬🔬 📄 Full Dossier | 🎙️ Podcast
Daily #mtDNA intel: • Cardiospecific POLG loss drives cardiomyopathy 🧬 • EV-mediated mtDNA transfer triggers osteoarthritis • Gstk1 inhibits cGAS/STING in sepsis 🔬 #genetics 📄 Full Dossier | 🎙️ Podcast
www.science.org/doi/10.1126/...
Rapid directed evolution guided by protein language models and epistatic interactions
Protein engineering is limited by the inefficient search through a high-dimensional sequence space to find combinations of synergistic mutations. Traditional approaches use stepwise mutation stacking,...
science.org
This argues against the hydrogen hypothesis of mitochondrial origin. 👇 www.nature.com/articles/s41... See also this excellent context (including a microscopy 🔬movie of crawling Asgards) by @carlzimmer.com: www.nytimes.com/2026/02/18/s...
Oxygen metabolism in descendants of the archaeal-eukaryotic ancestor - Nature
Sequencing of marine sediments finds 136 newly identified Heimdallarchaeia and several novel lineages, and indicates that Heimdallarchaeia evolved distinct metabolic capabilities from other Asgar...
nature.com
Daily #mtDNA intel: • Single-cell lineage tracing via inheritance 🧬 • USP10-MTX2 axis regulates cGAS-STING signaling • EV mtDNA transfers drive osteoarthritis 🔬 📄 Full Dossier | 🎙️ Podcast
One of the biggest questions in biology is how complex cells evolved about 2 billion years ago. Here's my new story on how scientists are solving the mystery of eukaryotes like us. Gift link: nyti.ms/4qMbo22
