1/ New preprint! with @solersanchisx.bsky.social @cwjpugh.bsky.social @federicobilleci.bsky.social @jonnyfrazer.bsky.social and Mafalda Dias, we introduce a scalable framework to improve stability prediction and separate folding from functional constraints. www.biorxiv.org/content/10.6...

Blending physics-based and inverse folding models to disentangle variant effects on stability and function

Protein sequences are constrained not only by the need to fold into stable structures, but also by specific functional requirements imposed by natural selection. Yet predictions of how amino-acid chan...

biorxiv.org

1/ We’ve been working on making it easier to fine-tune AlphaGenome on new RNA-seq samples, with a focus on one of my favourite regulatory layers: splicing! Blog post: genomicsxai.github.io/blogs/2026-0...

Applications are open for the @crg_eu PhD Programme! 20 fully funded positions — including one in our group through the Evolutionary Medical Genomics ITN. Join us to develop deep generative models of cross-species data to tackle open questions in disease genetics. www.crg.eu/en/content/t...

Centre de Regulació Genòmica (CRG)@crg.eu · 10mo ago

Are you looking for a PhD? Join us in Barcelona! You'll dive into a community of >100 PhD students from 30 countries exploring the frontiers of biology. You can also join an online workshop on 6 November (15:00 CET) to learn how to find the right lab for you. More info: www.crg.eu/en/content/t...

🧬🧬🧬 New review from the lab: Evolution of comparative transcriptomics: biological scales, phylogenetic spans, and modeling frameworks authors.elsevier.com/sd/article/S... By @mattezambon.bsky.social & @fedemantica.bsky.social, together with @jonnyfrazer.bsky.social & Mafalda Dias.

@cwjpugh.bsky.social at #VariantEffect25

How can we improve gene regulatory network inference from noisy scRNA-seq data? Our new review in @molsystbiol.org explores the latest methods integrating prior knowledge to enhance reliability. Plus, some suggestions on how to improve benchmarking! www.embopress.org/doi/full/10....

Leveraging prior knowledge to infer gene regulatory networks from single-cell RNA-sequencing data | Molecular Systems Biology

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

embopress.org

Art and science merged this afternoon in a wonderful concert from our fellow PhD candidate Matilda Pfeiffer toghether with the musician Clara Cantore in a performance reflecting on points of contact between music and science. Couldn’t be more happy to be part of this phd community 💫 #CRGPhDSymp2024

A highly relevant talk from Nico Lorenzon describing novel diagnostic tools to assess treatment resistance in Mayor Depressive Disorder #CRGPhDSymp2024

Attending a fascinating talk by Khashayar Baghizadeh on data-driven computational modeling of the Dentate Gyrus in Down Syndrome. Great work integrating anatomical and physiological data to unravel underlying mechanisms. #CRGPhDSymp2024

As the #CRGPhDSymp progresses, Leo Zuber gave an insightful talk on his research integrating spatial information with GWAS data for developing a spatially aware, tissue-specific genomic risk score, evaluated in the context of COVID-19 disease severity. 🦠🧬

Next up is Andrea Barrera! Presenting a fascinating talk which leaves us wondering, can metabolic intervention affect genome stability? #CRGPhDSymp2024

Kicking us off today is Tamara Perteghella from the Guigó lab with her talk on the latest release of #GENCODE, dramatically increasing the number of annotated lncRNAs. Well done to everyone involved in the consortium! #CRGPhDSymp2024

Sun is shining above PRBB for the second day of the 2024 PhD Symposium ☀️ I don’t think I’ll get tired anytime soon of sea’s view for my morning coffee 🤗 #CRGPhDSymp2024

Reporting from the #CRGPhDSymp2024 today and tomorrow! Kicking it off with a fascinating talk Gioia Quarantani on DMS of a 1000 exons to investigate alternative splicing

Very interesting talk from Pablo Lanuza about mechanistic understanding of splicing, titled SPF45 and 3'splice site proofreading. #CRGPhDSymp2024 #splicing

Navigating the #CRGPhDSymp2024 poster session, I’m slowly becoming an expert at nodding thoughtfully while frantically trying to understand someone’s life work in 3 minutes!

Great talk from Javier Navarro Delgado on understanding, predicting and engineering variant effects in synthetic antibodies. #AntibodyDiscover #CRGPhDSymp2024

Great talk from Laia Montes Espuna at the @crg.eu PhD Symposium! Her work is focused on cell type diversity in early metazoans, aiming at broadening the understanding of cell type identity programs across the animal kingdom 🪸🧬 #CRGPhDSymp2024

Our amazing CRG PhD community are celebrating their annual symposium today and tomorrow. Follow our first year students on Bluesky for snippets about all the amazing talks featured this year: @lassemiddendorf.bsky.social @mattezambon.bsky.social @iseultleahy.bsky.social

Big 🧬 news this week: we have launched the first Joint Program on Evolutionary Medical Genomics. Spearheaded by @mirimiam.bsky.social, Barcelona researchers will study and exploit the vast genomic diversity of life on Earth to enhance precision medicine. Full story in @elpais.com

The dawn of a new medicine: Researchers use the theory of evolution to fight cancer

The world’s first joint research program in evolutionary medical genomics has been launched in Barcelona, under the direction of biologist Manuel Irimia

english.elpais.com