AI is everywhere in biology right now, but how do these models actually hold up once they hit the lab? Our latest review on generative AI for enzyme design cuts through the hype to see what’s actually working in the lab🧪 ⬇️LINK

It's long seemed that molecular biology is a natural home for ML interpretability research, given the maturity of human-constructed models of biological mechanisms—permitting direct comparison with their ML-derived counterparts—unlike vision and NLP. Our first foray below👇.

Etowah Adams@etowah0.bsky.social · 2y ago

Can we learn protein biology from a language model? In new work led by @liambai.bsky.social and me, we explore how sparse autoencoders can help us understand biology—going from mechanistic interpretability to mechanistic biology.

Join the ProSE Seminar Series! A monthly discussion on the #Evolution of #ProteinStructure 🧪 Next up: Andrei Lupas “Highly repetitive genomic ORFs: a source of new fibrous proteins?” 11th February | 3 PM GMT 🔗 Register here: tinyurl.com/prose-seminar1

This is an important problem. 👏

bioRxiv Bioinfo@biorxiv-bioinfo.bsky.social · 2y ago

Detecting and avoiding homology-based data leakage in genome-trained sequence models https://www.biorxiv.org/content/10.1101/2025.01.22.634321v1

Highlighting the amazing research at the #CRGPhDSymp2024 Poster Session! Check out some snapshots from today’s sessions

Super interesting talk from Gül Aydin’s about understanding the role of dynamic DNA methylation at promoters during B-cell differentiation at the #CRGPhDSymp2024

Kicking us off today is Tamara Perteghella from the Guigó lab with her talk on the latest release of #GENCODE, dramatically increasing the number of annotated lncRNAs. Well done to everyone involved in the consortium! #CRGPhDSymp2024

PhD Symposium at @theprbb.bsky.social ! #PhD #symposium #prbb

People are slowly getting settled for the second day of the #CRGPhDSymp2024

Learning about cell type diversity and evolution beyond gene expression thanks to the amazing talk from Paulina Spurk at the PhD Symposium. #CRGPhDSymp2024

Great talk from Laia Montes Espuna at the @crg.eu PhD Symposium! Her work is focused on cell type diversity in early metazoans, aiming at broadening the understanding of cell type identity programs across the animal kingdom 🪸🧬 #CRGPhDSymp2024

Navigating the #CRGPhDSymp2024 poster session, I’m slowly becoming an expert at nodding thoughtfully while frantically trying to understand someone’s life work in 3 minutes!

Great talk from Javier Navarro Delgado on understanding, predicting and engineering variant effects in synthetic antibodies. #AntibodyDiscover #CRGPhDSymp2024

Very interesting talk from Pablo Lanuza about mechanistic understanding of splicing, titled SPF45 and 3'splice site proofreading. #CRGPhDSymp2024 #splicing

Thanks Charlie for opening the PhD Symposium! Many thanks to everyone involved in its organisation. #CRGPhDSymp2024

Next up we have @javibiotec.bsky.social talking on using large-scale mutational experiments to understand the genetic architecture of nanobody stability #CRGPhDSymp2024

Reporting from the #CRGPhDSymp2024 today and tomorrow! Kicking it off with a fascinating talk Gioia Quarantani on DMS of a 1000 exons to investigate alternative splicing

Our amazing CRG PhD community are celebrating their annual symposium today and tomorrow. Follow our first year students on Bluesky for snippets about all the amazing talks featured this year: @lassemiddendorf.bsky.social @mattezambon.bsky.social @iseultleahy.bsky.social

Ah, we have several positions open!