🧬 1/ HP1α marks silenced heterochromatin, but how does it repress, and what happens when transcription is switched on? On mouse fibroblast chromocenters, HP1α stays bound, its barrier is local, and the domain reorganizes nanodomain by nanodomain. 👉 @cp-molcell.bsky.social doi.org/10.1016/j.mo...

1/ Do cells use phase separation to adapt biosynthetic output to changing demands? In our new preprint, we show that under nutrient limitation, the nucleolus enters a reversible ‘hibernation’ state that slows ribosome biogenesis. See doi.org/10.64898/202...

In-cell structures visualize human pre-ribosome assembly in the nucleolus https://www.biorxiv.org/content/10.64898/2026.06.01.729245v1

(1/n) Super excited to share that our preprint is out today in @natsmb.nature.com with a new name "Integrated MINFLUX tracking reveals two distinct chromatin dynamics classes across cell types" and more than 2x more data: www.nature.com/articles/s41... See also MIT News news.mit.edu/2026/how-chr...

Anders Sejr Hansen@andersshansen.bsky.social · last yr.

(1/n) Thread @matteomazzocca.bsky.social @domenicnarducci.bsky.social Simon Grosse-Holz @jessematthias.bsky.social preprint Q: how does chromatin move? Using MINFLUX, SPT & SRLCI, we track chromatin dynamics across 7 orders of magnitude in time to provide answers www.biorxiv.org/content/10.1...

Spectral multiplexing is typically limited to 4-5 channels. Our new preprint introduces a framework that utilizes DNA barcoding and signal tuning to enable robust spectral unmixing and ground-truth benchmarking to achieve 15-plex subcellular profiling without cycling www.biorxiv.org/content/10.6...

Kristina@jekristina.bsky.social · 6mo ago

Ever felt constrained by the "4-color limit" in fluorescence imaging? We use DNA-barcoded labeling to build high-plex panels, enabling imaging of 15 targets across the full fluorescence spectrum. doi.org/10.64898/202... Grateful to @sinemsaka.bsky.social and all authors for making this possible.

Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social doi.org/10.1016/j.ce... Read the thread👇 for the highlights of our findings.

Out now in @science.org Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes | Science www.science.org/doi/10.1126/...

Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes

Cells down-regulate protein synthesis when stressed to conserve energy and shift resources toward repair. We found that in some mammalian cells, including neurons, stress also resulted in the formatio...

science.org

Last week marked the end of my postdoc at #RibackLab. I spent three exciting and productive years at BCM, but it’s now time for the next chapter. Thank you to @superscijew.bsky.social for being a great mentor and to my colleagues for all the fun and science we shared together!

Happy to share that my PhD project is finally published!🪱✨ Selfish genes are found across the tree of life. They can disrupt inheritance patterns and at the same time act as units for molecular innovation. Here we tried to answer one big question: how do selfish genes emerge in the first place?

Nature Ecology & Evolution@natecoevo.nature.com · 10mo ago

Recurrent evolution of selfishness from an essential tRNA synthetase in Caenorhabditis tropicalis 🧪 www.nature.com/articles/s41...

(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies.

Our lab's first preprint is out! I'm glad to be part of this project - take a look!

Josh Riback@superscijew.bsky.social · 2y ago

In lab’s #FIRSTPREPRINT, we present methods to measure nanometer-scale organization around & between specific proteins in condensates in live cells. We uncover unexpected heterogeneity for a liquid-like phase with local meshwork spanning 10-50nm, stemming from ribosome biogenesis in the nucleolus.