"Eine Augensalbe aus 'Bald's Leechbook', einem medizinischen Kompendium aus dem 10. Jahrhundert, hat erstaunliche Wirkungen – zumal gegen multiresistente Bakterien." www.derstandard.at/story/300000... cc @friendlymicrobe.bsky.social, @norselass.bsky.social #histmed #medievalsky

Wie ein über tausend Jahre altes Rezept gegen moderne Superkeime helfen könnte

Eine Augensalbe aus "Bald's Leechbook", einem medizinischen Kompendium aus dem 10. Jahrhundert, hat erstaunliche Wirkungen – zumal gegen multiresistente Bakterien

derstandard.at

Für jeder die Deutsch sprecht, und interessiert sich für #Ancientbiotics. @tosinorababa.bsky.social war der Kopf hinter dieser Forschung! #MIcroSky

Tobias Niedenthal@klostermedizin.de · 6d ago

"Eine Augensalbe aus 'Bald's Leechbook', einem medizinischen Kompendium aus dem 10. Jahrhundert, hat erstaunliche Wirkungen – zumal gegen multiresistente Bakterien." www.derstandard.at/story/300000... cc @friendlymicrobe.bsky.social, @norselass.bsky.social #histmed #medievalsky

It’s International Microorganism Day! For a third year running, some of our Champions have told us about their favourite microbes and our very talented Champion, Eliza Wolfson, has brought these to life with her illustrations! @eliza-coli.bsky.social @femsmicro.org

Charlotte Wainwright restoring and saving old/ancient books. www.wainwrightbookbinding.com

Thrilled our latest paper out @natureportfolio.nature.com Nature Comms, lead author @microberamon.bsky.social, who developed P-FLO, a urine-flowing human micro-bladder model in collab with Oxford & Leicester to understand #UTI biology & treatment failure 1/4 #UTISky www.nature.com/articles/s41...

Effect of human urinary microenvironment and fluid flow on antibiotic and phage therapy efficacy against uropathogenic Escherichia coli - Nature Communications

Maset et al. show that bladder conditions strongly influence how urinary tract infections respond to antibiotics and bacteriophages, highlighting the need for more realistic lab models to improve diag...

nature.com

Excited to share our new publication (in mSphere) describing the mechanism of action and general bacterial (S. aureus and A. baumannii) response to Bald’s eyesalve - a reconstructed historical antimicrobial remedy. journals.asm.org/doi/10.1128/...

Uncovering the mechanism of action of a historical antimicrobial against S. aureus and A. baumannii | mSphere

The increasing mortality and economic cost of antimicrobial resistance (AMR) have made it one of the biggest threats to global health. Available antibiotics are in short supply due to the slow progres...

journals.asm.org

Freya Harrison@friendlymicrobe.bsky.social · last mo.

It's taken 12 years and a lot of work from many fantastic people, but we have published an analysis of how our reconstruction of Bald's eyesalve kills bacteria. This was driven by @tosinorababa.bsky.social & Jess Furner-Pardoe through their PhD work #MicroSky journals.asm.org/doi/10.1128/... [1/n]

Excited to share our new publication (in mSphere) describing the mechanism of action and general bacterial (S. aureus and A. baumannii) response to Bald’s eyesalve - a reconstructed historical antimicrobial remedy. journals.asm.org/doi/10.1128/...

Uncovering the mechanism of action of a historical antimicrobial against S. aureus and A. baumannii | mSphere

The increasing mortality and economic cost of antimicrobial resistance (AMR) have made it one of the biggest threats to global health. Available antibiotics are in short supply due to the slow progres...

journals.asm.org

Freya Harrison@friendlymicrobe.bsky.social · last mo.

It's taken 12 years and a lot of work from many fantastic people, but we have published an analysis of how our reconstruction of Bald's eyesalve kills bacteria. This was driven by @tosinorababa.bsky.social & Jess Furner-Pardoe through their PhD work #MicroSky journals.asm.org/doi/10.1128/... [1/n]

It's taken 12 years and a lot of work from many fantastic people, but we have published an analysis of how our reconstruction of Bald's eyesalve kills bacteria. This was driven by @tosinorababa.bsky.social & Jess Furner-Pardoe through their PhD work #MicroSky journals.asm.org/doi/10.1128/... [1/n]

Oxalate-mediated detoxification and bioaccumulation of lead and cadmium in Escherichia coli K-12 MG1655. Published Open Access and fee-free in Microbiology using a Publish and Read agreement: https://doi.org/10.1099/mic.0.001728 #Mic #PublishAndRead

New preprint of our work on effects of intra-strain diversity of Pseudomonas on modulating host response is out! Some variants of concern, flip the switch in host responses! www.biorxiv.org/content/10.6...

Preprint from @tosinorababa.bsky.social and a crack team he assembled to explore the mechanism of action of tEDTA against P. aeruginosa #MicroSky

bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 2mo ago

Tetrasodium EDTA disrupts Pseudomonas aeruginosa membrane integrity, shows suppressed resistance evolution and reduced cytotoxicity compared to meropenem https://www.biorxiv.org/content/10.64898/2026.08.11.744140v1

Tetrasodium EDTA disrupts Pseudomonas aeruginosa membrane integrity, shows suppressed resistance evolution and reduced cytotoxicity compared to meropenem https://www.biorxiv.org/content/10.64898/2026.08.11.744140v1

Low concentrations of tetrasodium EDTA kill P. aeruginosa biofilm in some, but not all, chronic infection models. New paper proposed & designed by @tosinorababa.bsky.social, who led a team of PhD students to get this research done www.microbiologyresearch.org/content/jour... #MicroSky

Low concentrations of tetrasodium EDTA cause significant killing of biofilm-associated Pseudomonas aeruginosa in high-validity models of chronic wound and cystic fibrosis lung infections – but not in ...

Pseudomonas aeruginosa is a pathogen notorious for its antimicrobial resistance and is currently classified as a high-priority pathogen for which new drugs are needed. Tetrasodium EDTA (tEDTA) is one ...

microbiologyresearch.org

Does media matter? RNAseq of S. aureus growing in LB broth vs. synthetic wound fluid shows differential expression of genes involved in efflux, virulence & ion transport. Work led by @tosinorababa.bsky.social: his first manuscript from independent funding! #MicroSky www.biorxiv.org/content/10.6...

Does media matter? Growth environment influence antimicrobial tolerance and expression of virulence and transmembrane ion transport-associated genes in MRSA

Clinically relevant pathogens are often tested for antimicrobial susceptibility using standard laboratory media that poorly reflect the in vivo environments in which they cause infections, leading to ...

biorxiv.org

Does media matter? Growth environment influence antimicrobial tolerance and expression of virulence and transmembrane ion transport-associated genes in MRSA https://www.biorxiv.org/content/10.64898/2026.06.15.732343v1

Our work on understanding how Staphylococcus aureus mode of cell division contributes to pathogenesis is now available in bioRxiv

bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 7mo ago

Orthogonal cell division organizes surface virulence factors to drive staphylococcal abscess community formation https://www.biorxiv.org/content/10.64898/2026.03.12.711374v1

Does media matter? Growth environment influence antimicrobial tolerance and expression of virulence and transmembrane ion transport-associated genes in MRSA https://www.biorxiv.org/content/10.64898/2026.06.15.732343v1

Very proud to share that @tosinorababa.bsky.social has been awarded the prize for best PhD thesis by a @warwicklifesci.bsky.social student for 2025. Massive congratulations, Tosin! 🎉🥳 #MicroSky

Freya Harrison@friendlymicrobe.bsky.social · 6mo ago

Come to #Microbio26 poster 094 to hear all about natural product antimocrobial discovery from @tosinorababa.bsky.social and me #MicroSky

Come to #Microbio26 poster 094 to hear all about natural product antimocrobial discovery from @tosinorababa.bsky.social and me #MicroSky

JOB ALERT: Two 4.5 year postdoctoral positions to work on my Wellcome-funded project 'Conserving Global Health: Biodiversity Protection and the Prehistory of Planetary Health'. Please share widely! CLOSING DATE: 23 April (the date on Jobs.ac.uk is apparently incorrect)

Lastly, we show that it is harder for bacteria (S. aureus, A. baumannii, and P. aeruginosa) to develop resistance against this complex infection remedy compared to some mainline antibiotics.

This mechanism of action includes bacterial membrane disruption, nucleic acid biosynthesis inhibition via the inhibition of de novo purine and pyrimidine pathway, quorum sensing inhibition, and inhibition of bacterial adhesion (2/n).

Excited to share our preprint that describes the mechanism of action of an historical infection remedy called Bald’s Eyesalve. In this preprint, we show that Bald’s Eyesalve has multifaceted mechanism of action against both S. aureus and A. baumannii (1/n).

Freya Harrison@friendlymicrobe.bsky.social · 8mo ago

Remember the medieval remedy we reconstructed years ago? We've now dissected the various ways it attacks and kills bacteria! Preprinted & submitted, led by @tosinorababa.bsky.social & Jess Furner-Pardoe w/ many collaborators #MicroSky #Ancientbiotics www.biorxiv.org/content/10.6...

Excited to share our preprint that describes the mechanism of action of an historical infection remedy called Bald’s Eyesalve. In this preprint, we show that Bald’s Eyesalve has multifaceted mechanism of action against both S. aureus and A. baumannii (1/n).

Freya Harrison@friendlymicrobe.bsky.social · 8mo ago

Remember the medieval remedy we reconstructed years ago? We've now dissected the various ways it attacks and kills bacteria! Preprinted & submitted, led by @tosinorababa.bsky.social & Jess Furner-Pardoe w/ many collaborators #MicroSky #Ancientbiotics www.biorxiv.org/content/10.6...

Remember the medieval remedy we reconstructed years ago? We've now dissected the various ways it attacks and kills bacteria! Preprinted & submitted, led by @tosinorababa.bsky.social & Jess Furner-Pardoe w/ many collaborators #MicroSky #Ancientbiotics www.biorxiv.org/content/10.6...

Why should microbiologists be interested in historical infection remedies, and how can we best investigate them for antimicrobial discovery? Thoroughly enjoyed co-writing this Microbiology Primer with @tosinorababa.bsky.social www.microbiologyresearch.org/content/jour... #MicroSky #Ancientbiotics

Microbial Primer: Ancientbiotics – making modern antimicrobials from historical infection remedies

The modern antibiotic era began in the early twentieth century, but humans have long used materials from the natural world to attempt to treat the symptoms of infection. In this primer, we will discus...

microbiologyresearch.org

pubmed.ncbi.nlm.nih.gov/37117030/ Does anyone here have access to the full text of this paper🙏? I have tried emailing the authors but didn’t get any response (more than a month now). Thank you in advance

Construction of a Staphylococcus aureus Gene-Deletion Allelic-Exchange Plasmid by Gibson Assembly and Recovery in Escherichia coli - PubMed

We present a protocol for the generation of a gene-deletion allelic-exchange plasmid and its recovery in <i>Escherichia coli</i> for the purpose of constructing an in-frame gene deletion in <i>Staphylococcus aureus</i> Here, we present detailed methodologies for (i) the primer design (using the <i>S</i> …

pubmed.ncbi.nlm.nih.gov

pubmed.ncbi.nlm.nih.gov/37117030/ Does anyone here have access to the full text of this paper🙏? I have tried emailing the authors but didn’t get any response (more than a month now). Thank you in advance

Construction of a Staphylococcus aureus Gene-Deletion Allelic-Exchange Plasmid by Gibson Assembly and Recovery in Escherichia coli - PubMed

We present a protocol for the generation of a gene-deletion allelic-exchange plasmid and its recovery in <i>Escherichia coli</i> for the purpose of constructing an in-frame gene deletion in <i>Staphylococcus aureus</i> Here, we present detailed methodologies for (i) the primer design (using the <i>S</i> …

pubmed.ncbi.nlm.nih.gov

Excited to have been selected as an Infection Science Awardee for 2025 by the Microbiology Society. Looking forward to presenting my research at this year’s Federation of Infection Science Conference in Bournemouth.

Microbiology Society@microbiologysociety.org · 11mo ago

🎉 Congratulations to Oluwatosin Orababa @tosinorababa.bsky.social, one of the winners of our 2025 Infection Science Award! 🦠👏 Get to know them in our new interview: microb.io/3XFyCui #InfectionScience #Microbiology #ResearchSpotlight