Félix Ramos-León
@felixrl.bsky.social
Postdoctoral fellow at NIH studying cell biology of coccoid bacteria. Views my own. He/him/Él 🏳️🌈
PLEASE SHARE! New job openings in my lab @zmbp-tuebingen.bsky.social. We have a broad interest into the mechanistic basis of how molecular complexes are rewired during cellular development in plants and during invasion by pathogens. 🌱🍄🔬 See details below 👇 #PlantSciJobs
We investigated and identified several skin-derived bacteria that antagonize common pathogenic species: www.nature.com/articles/s41... A cool highlight was that bacteria from feet, where fungi are particularly diverse, tended to be more broadly antifungal than those from other body sites! #microevo
Large-scale investigation for antimicrobial activity reveals newly-identified defensive species across the healthy skin microbiome - Nature Communications
Authors present the EPithelial Isolate Collection (EPIC), a large skin microbiome culture collection, uncovering new species, widespread antifungal activity, and hidden biosynthetic diversity, reveali...
nature.com
A TmaT-AftD interaction is required for the CmpL4 mycomembrane biogenesis pathway in Corynebacterium glutamicum. https://www.biorxiv.org/content/10.64898/2026.07.31.741767v1
Cpf1(Cas12a)-based genome editing in the filamentous cyanobacterium Nostoc punctiforme https://www.biorxiv.org/content/10.64898/2026.07.31.742098v1
A c-di-AMP-controlled glutamine synthesis pathway promotes persistence of Staphylococcus aureus thymidine-dependent small colony variants in the lung https://www.biorxiv.org/content/10.64898/2026.07.30.741254v1
New pre-print from the lab, about impact of cell wall antibiotics on PG elongation machineries. Any comments and (constructive) criticism are welcome!
bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 2w agoDifferential impact of cell wall antibiotics on the Rod complex and aPBPs in Bacillus subtilis: Insights into the peptidoglycan elongation machineries https://www.biorxiv.org/content/10.64898/2026.07.24.740396v1
And two more pre-prints from the lab, focusing on MreB polymerization cycle and dynamics! www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.6...
A genetic screen unveils the polymerization cycle of the bacterial actin-like MreB
MreB, a bacterial actin homologue that organizes cell wall synthesis in most rod-shaped bacteria, assembles into membrane-associated filaments through mechanisms that have remained elusive despite dec...
biorxiv.org
Outer membrane remodeling via lipid-peptidoglycan crosstalk enables lipooligosaccharide-deficient colistin resistance
Outer membrane remodeling via lipid-peptidoglycan crosstalk enables lipooligosaccharide-deficient colistin resistance
Olea-Ozuna et al. show that outer membrane lipid asymmetry acts as a checkpoint controlling lipooligosaccharide-independent survival in Acinetobacter baumannii. Disrupting phospholipid homeostasis creates a permissive state enabling LOS loss under colistin selection, while reduced PBP1A activity stabilizes this transition, defining a three-state model of envelope remodeling and resistance.
dlvr.it
Differential impact of cell wall antibiotics on the Rod complex and aPBPs in Bacillus subtilis: Insights into the peptidoglycan elongation machineries https://www.biorxiv.org/content/10.64898/2026.07.24.740396v1
A genetic screen unveils the polymerization cycle of the bacterial actin-like MreB https://www.biorxiv.org/content/10.64898/2026.07.23.740262v1
Host and antibiotic jointly select for greater virulence in <i>Staphylococcus aureus</i>
Host and antibiotic jointly select for greater virulence in Staphylococcus aureus
Antibiotic resistance alters pathogen evolutionary trajectory.
buff.ly
Multi-omics analysis identifies a role for Streptococcus suis MnmE in growth regulation and environmental adaptation 🦠 journals.asm.org/doi/10.1128/...
Multi-omics analysis identifies a role for Streptococcus suis MnmE in growth regulation and environmental adaptation | Microbiology Spectrum
Streptococcus suis is a major swine and zoonotic pathogen. While bacterial tRNA modifications are known to fine-tune translation, their role in coordinating pathogenesis and stress adaptation remains…
journals.asm.org
Our new preprint is out! We investigate chromosome organization in obligate mammalian symbionts and show that these bacteria maintain stable chromosome orientations while displaying conserved lifestyle-associated chromosome architectures across species. www.biorxiv.org/cgi/content/...
earlier, we learned about longitudinal cell division in three Neisseriaceae, very bacterial caterpillars ( smallthingsconsidered.blog/schaechter/2...). now, we learn how they organize their chromosomes under different growth conditions & growth phases...
@sbulgheresi.bsky.social · 2w agoOur new preprint is out! We investigate chromosome organization in obligate mammalian symbionts and show that these bacteria maintain stable chromosome orientations while displaying conserved lifestyle-associated chromosome architectures across species. www.biorxiv.org/cgi/content/...
Cyanobacteria form suspended #biofilm in response to attack by predatory bacteria - really cool study! Comment: www.the-microbiologist.com/news/bacteri... & original article: academic.oup.com/ismej/advanc... #MicroSky
Bacteria form ‘herds’ to survive predators, offering fresh insight into Earth’s carbon cycle
Researchers have discovered that tiny photosynthetic bacteria band together into protective 'herds' when attacked by predators - a survival strategy that could also influence how carbon is stored in t...
the-microbiologist.com
Systematic identification of cell division proteins in haloarchaea and the discovery of a membrane anchor for the Z ring https://www.biorxiv.org/content/10.64898/2026.07.16.738847v1
Structural basis of biofilm formation mediated by the Pseudomonas aeruginosa fibrillar adhesin CdrA led by @olivia--smith.bsky.social Collaboration with @alexbateman1.bsky.social , Andres Floto and @geiselbiofilm.bsky.social labs
Fresh out of the lab! Our new preprint is now up on BioRxiv, exploring how the beneficial bacterium Pseudomonas putida controls its T6SS nanoweapon. It turns out the Gac/Rsm pathway acts as a strict molecular brake on the system. 👇 (1/4) Read the full preprint here: doi.org/10.64898/202...
New preprint! We show that the bacterial predator B. bacteriovorus deploys a unipolar Tad nanomachine for irreversible attachment to prey and invasion. @coralietesseur.bsky.social used CRISPRi+microfluidics to overcome barriers associated with essential systems in an obligate predatory lifestyle 🦠
A polarity-controlled Tad nanomachine enables prey invasion in a bacterial predator
Type IV pili are dynamic surface appendages assembled by envelope-spanning nanomachines that mediate diverse bacterial interactions, yet how these systems are adapted to predatory lifestyles remains p...
biorxiv.org
👉 Self-generated hydrogel ejects bacterial cells for localized biofilm dispersion: www.nature.com/articles/s41... #subtiwiki
Self-generated hydrogel ejects bacterial cells for localized biofilm dispersion - Nature Microbiology
Bacillus subtilis biofilms locally disperse by ejecting motile cells through osmotic pressure generated by their poly-γ-glutamic acid hydrogel, a mechanism resembling that through which Cnidaria eject...
nature.com
👉 Differential signaling roles of the KinA-KinE sensor kinases in regulating Spo0A, the master regulator of Bacillus subtilis cell‑fate decisions: www.sciencedirect.com/science/arti... #subtiwiki
Differential signaling roles of the KinA-KinE sensor kinases in regulating Spo0A, the master regulator of Bacillus subtilis cell‑fate decisions
The Spo0A phosphorelay integrates inputs from five sensor kinases (KinA-KinE), with KinD and KinE less well characterized, to control developmental pr…
sciencedirect.com
[🚨] Publication alert! Years of hard work is now published in @pnas.org - www.pnas.org/doi/full/10.... It's not everyday that a novel biosynthetic intermediate is identified in bacteria, so this warrants a short summary below [👇] 1/7
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
pnas.org
Metabolic profiling of S. aureus revealed suppressed central carbon and energy metabolism as a shared resistance mechanism. Notably, supplementation with metabolites like pyruvate, citrate, and fumarate enhanced antibiotic efficacy. #JournalSpectrum: asm.social/2ZV
Discovery of an adhesion GPCR regulating mating in choanoflagellates, by Alain Garcia de las Bayonas & Nicole King. Absolutely stunning work - choano cell biology is going next level www.biorxiv.org/content/10.6...
Carboxypeptidase activity drives L,D-transpeptidase essentiality during vegetative growth and sporulation in Clostridioides difficile www.biorxiv.org/content/10.6...
Carboxypeptidase activity drives L,D-transpeptidase essentiality during vegetative growth and sporulation in Clostridioides difficile
In most bacteria, peptidoglycan contains mainly 4-3 crosslinks formed by penicillin-binding proteins (PBPs). But in the opportunistic pathogen Clostridioides difficile , 70% of the crosslinks are 3-3 ...
biorxiv.org
Engineering Modular Cargo Loading Strategies for Carboxysome-Derived Protein Particles | ACS Synthetic Biology @cellforganized.bsky.social
Engineering Modular Cargo Loading Strategies for Carboxysome-Derived Protein Particles
Bacterial microcompartments (BMCs) are a diverse and widespread class of self-assembling protein-based organelles consisting of a semipermeable protein shell encapsulating an enzymatic core. Isolated ...
pubs.acs.org
Conservation and evolution of the ribosome across the photosynthetic lineage🦠🍓''gain and loss of ribosomal proteins, rRNA modifications and hibernation factors upon endosymbiosis'' www.biorxiv.org/content/10.6...
Conservation and evolution of the ribosome across the photosynthetic lineage
Regulated biogenesis of photosynthetic proteins by the chloroplast ribosomes is central to plant development and environmental adaptation. Here, we describe changes to the ribosome that occurred durin...
biorxiv.org
Bactofilins are essential spatial organizers of peptidoglycan insertion in the Lyme disease spirochete Borrelia burgdorferi journals.asm.org/doi/10.1128/... #MicroSky
Bactofilins are essential spatial organizers of peptidoglycan insertion in the Lyme disease spirochete Borrelia burgdorferi | Journal of Bacteriology
The spirochetal bacterium Borrelia burgdorferi causes Lyme disease, the most prevalent vector-borne infection in North America and Europe. Cellular replication, which requires growth and division of t...
journals.asm.org
