Great work led by @marcostock.bsky.social and Florin Ratajczak , thanks to all coauthors Paul Bertin @evahoermanseder.bsky.social @yoshuabengio.bsky.social Jason Hartford @interactome.bsky.social Matthias Heinig @alextong.bsky.social

The credit goes to my colleagues @meghana-oak.bsky.social and @marcostock.bsky.social, who drove this project and continued these demanding experiments with incredible persistence

Great team effort, led by @marcostock.bsky.social , with Corinna Losert, @mattezambon.bsky.social, Niclas Popp, Gabriele Lubatti, @evahoermanseder.bsky.social & Matthias Heinig

✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨ 📄 Check it out here:
doi.org/10.1101/2025... 👇 Highlights below

H3K4 methylation-promoted transcriptional memory ensures faithful zygotic genome activation and embryonic development

In the life of a vertebrate embryo, gene expression is initiated for the first time at zygotic genome activation (ZGA). Maternally expressed transcription factors present in the embryo are essential f...

doi.org

UMAP applied to 100 randomly generated points from a multivariate normal distribution simplystatistics.org/posts/2024-1...

We present Gene Regulatory nETwork Analsyis (GRETA), a framework to infer, compare and evaluate gene regulatory networks #GRNs. With it, we have benchmarked multimodal and unimodal GRN inference methods. Check the results here 👇 Paper: doi.org/10.1101/2024.12.20.629764 Code: github.com/saezlab/greta

Learning on graphs 2024 recordings are all available online: youtube.com/watch?v=Af-_... logconference.org what a great resource!

Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. www.nature.com/articles/s41...

ChIP-DIP maps binding of hundreds of proteins to DNA simultaneously and identifies diverse gene regulatory elements - Nature Genetics

ChIP-DIP (ChIP done in parallel) is a highly multiplex assay for protein–DNA binding, scalable to hundreds of proteins including modified histones, chromatin regulators and transcription factors, offe...

nature.com