Eva Hörmanseder
@evahoermanseder.bsky.social
Science at work / Mom, Gardener & Knitter 🧶 at home Scientific Grant Coordinator at IMP Vienna Love for Development, Reprogramming, Epigenetics and Xenopus 🐸
Have a look at this PhD program in Vienna- most interesting science and the best training program:
Vienna BioCenter Scientific Training@vbcscitraining.bsky.social · 7mo agoThe Vienna BioCenter PhD program in Molecular BioSciences will offer 25+ fully-funded positions in the Spring Call which is now open. Check the vacancies in this call: www.vbcphd.at Institute of Molecular Biotechnology, Max Perutz Labs Vienna, IMP, Gregor Mendel Institute of Molecular Plant Biology
International Genome Dynamics course in Institut Curie-Paris (April 8-15), experimental and computational methods in multiomics,with a #TE centered session. Free registration, until Jan 15th Don’t miss it! 👉https://training.institut-curie.org/courses/Genome-Dynamics-2026 @institutcurie.bsky.social
Now final version out: Our manuscript connecting histone modifications with metabolism: How H4K16 acylations regulate inter +intranucleosomal interactions and confer resilience to metabolic challenges in vivo. Thanks to the team+ @sandrani.bsky.social Enjoy 👇👇 www.cell.com/molecular-ce...
H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations
Nitsch et al. show that short-chain acylations of histone H4K16, acetylation (C2), propionylation (C3), and butyrylation (C4) modulate chromatin structure in vitro. These effects can translate in vivo...
cell.com
Happy birthday to Xenbase! Our research would have not been possible without you and your fantastic community support 🤩
Xenbase@xenbase.bsky.social · 9mo ago25 years of Xenbase. www.xenbase.org/xenbase/doNe... #science #devbio #xenopus #frogs
Our preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)
Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo
Enhancers control tissue-specific gene expression across metazoans. Although deep learning has enabled enhancer prediction and design in mammalian cell lines and invertebrate systems, it remains uncle...
biorxiv.org
Our new preprint is out: www.biorxiv.org/content/10.6... We show that GRN benchmarks commonly used can overestimate performance due to negative-sampling choices, sometimes allowing simple degree-based baselines to rival more complex GNNs. A reminder of why bias-aware evaluation matters!
Hidden sampling biases inflate performance in gene regulatory network inference
Accurate reconstruction of gene regulatory networks (GRNs) from single-cell transcriptomic data remains a major methodological challenge. Recent machine learning approaches, particularly graph neural ...
biorxiv.org
After a long journey, I'm happy to share that my PhD work is finally published in Nature Communications. Grateful to all my co-authors!
Eva Hörmanseder@evahoermanseder.bsky.social · 10mo agoWe probably shouldn’t have favourites amongst projects in the lab, but this one was mine. I’m so pleased we can finally share it: Our work is now out in Nature Communications: 🔗 nature.com/articles/s41467-025-67692-7
We probably shouldn’t have favourites amongst projects in the lab, but this one was mine. I’m so pleased we can finally share it: Our work is now out in Nature Communications: 🔗 nature.com/articles/s41467-025-67692-7
nature.com
Do you want to play a key role in running a cutting-edge stem cell and embryology lab at reNEW @ucph.bsky.social ? We’re hiring a Lab Manager to support our team and help with stem cell and animal work. Apply before Feb. 1st : rb.gy/d5uf17
Academic employee for Research Group, Dept. of Biomedical Sciences, reNEW
rb.gy
I’m thrilled to share that our project, FATERNA, has been awarded an ERC Consolidator Grant! We’ll explore the mechanisms of pre-mRNA fate control. Huge thanks go to our awesome research team, colleagues, and the fantastic support from @impvienna.bsky.social & @viennabiocenter.bsky.social CP.
European Research Council (ERC)@erc.europa.eu · 10mo agoThe results of the ERC Consolidator Grant call have been announced! 📣 349 researchers have been selected for funding. Congratulations to all! #ERCCogG! 👉 buff.ly/uu62uFV #FrontierResearch #EUfunded #HorizonEurope @scienceinnovation.ec.europa.eu
Excited to announce that our peer-reviewed manuscript is online in the Development journal @dev-journal.bsky.social. The manuscript was much improved through the peer-review process, and I am grateful to the reviewers for their valuable feedback. journals.biologists.com/dev/article/...
Feed-forward loops by NR5A2 ensure robust gene activation during pre-implantation development
Pioneer transcription factors are crucial for regulating zygotic genome activation and cell differentiation during mouse pre-implantation development. However, how pioneer factors function collectivel...
journals.biologists.com
A close-up piece on the legacy of Sir John Gurdon - so happy to see this out at @natcomms.nature.com. Excellent editorial and community work by @ebardot.bsky.social & thank you, @evahoermanseder.bsky.social et al.! www.nature.com/articles/s41...
Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon - Nature Communications
Nature Communications - Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon
nature.com
We have just published a tribute to John Gurdon, reflecting on his scientific legacy and the profound influence he had on generations of developmental biologists. The piece is available open access in Nature Communications: www.nature.com/articles/s41...
Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon - Nature Communications
Nature Communications - Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon
nature.com
We are honored to share our Perspective in Nature Communications, reflecting on the legacy of John B. Gurdon. Beyond his discoveries, his generosity and curiosity inspired a community of scientists-we remember and celebrate his lasting impact. #JohnGurdon #Xenopus #NatureCommunications
Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon
Nature Communications - Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon
rdcu.be
The Americans are doing to Kseniia what the Russians did to Brittney Griner for having 0.7 grams of cannabis oil. Except no one is coming to negotiate her freedom and Harvard is sitting on their hands. I am so ashamed. Please share this story. www.nytimes.com/2025/04/11/s...
She Worked in a Harvard Lab to Reverse Aging, Until ICE Jailed Her (Gift Article)
President Trump’s immigration crackdown ensnared Kseniia Petrova, a scientist who fled Russia after protesting its invasion of Ukraine. She fears arrest if she is deported there.
nytimes.com
#EpigeneticsPodcast with #HelmholtzMunich expert Dr. Eva Hörmanseder, @epihmgu.bsky.social! 🎧 Listen and learn about epigenetic memories & more: 👉 t1p.de/30q54 👉Check out her latest findings on this topic: t1p.de/43yrw @epigeneticspod.bsky.social #Epigenetics #Podcast #Reprogramming #CellFate
Epigenetics Podcast@epigeneticspod.bsky.social · 2y agoIn this episode of the Epigenetics Podcast, we talked with @evahoermanseder.bsky.social from @www.helmholtz-munich.de about her work on epigenetic mechanisms in cellular memory and gene regulation. #podcast #epigenetics Listen here: activemotif.com/podcasts-eva...
In the most recent episode we talked with @evahoermanseder.bsky.social from @www.helmholtz-munich.de about her work on epigenetic mechanisms in cellular memory and gene regulation. #podcast #epigenetics Listen here: activemotif.com/podcasts-eva...
This is very disturbing. Harvard PhD student Kseniia Petrova (Russian citizen) was arrested by ICE for transporting xenopus embryos into Boston from Paris. She has been detained in Louisiana since Feb. 16. www.theguardian.com/us-news/2025...
Russian scientist working at Harvard detained by Ice at Boston airport
Kseniia Petrova was returning to the US from a trip to France when officials revoked her visa and detained her
theguardian.com
If I could do it all over again, I’d apply here for my postdoc- look at these fantastic opportunities! ⬇️
Anja Groth@groth-anja.bsky.social · 2y agoA few days left to apply for exciting PhD and Postdoc opportunities in wonderful Copenhagen and join our efforts in understanding Epigenetic Cell Memory.
Reprogramming efficiency varies across cell types in vivo and is modulated by somatic cell identity memory. Eliminating somatic cell transcriptional memory improves reprogramming success #nucleartransfer ow.ly/g1Au50VimTM @www.helmholtz-munich.de @isscr.org
We’d like to thank our Editors and peer reviewers who made the #fastandfairpeerreview trial possible. Would you like to join our reviewer pool? Visit bit.ly/41N31tO for more details.
Harvard scientist opposed to Ukraine war faces deportation back to Russia: Friends. This sounds like Trump trying to please Putin rather than anything to do with US immigration. www.independent.co.uk/news/world/a...
Harvard scientist opposed to Ukraine war faces deportation back to Russia: Friends
Kseniia Petrova has been in U.S. detention since mid-February after having her visa revoked, according to friends and independent Russian media
independent.co.uk
Our key collaborator, genius scientist and wonderful person Kseniia is in a horrendous situation right now, see article below. Why? Trump. Please share, please do not ignore, if you can, help. www.independent.co.uk/news/world/a...
Harvard scientist opposed to Ukraine war faces deportation back to Russia: Friends
Kseniia Petrova has been in U.S. detention since mid-February after having her visa revoked, according to friends and independent Russian media
independent.co.uk
Thank you very much for this possibility to contribute to this podcast! …but, as it said in my recommendation letter, “she has a tendency to talk fast” :) Thanks to everyone who contributed to these discoveries discussed here 🙏 Especially to those I forgot to mention cause I was so nervous…
listening.as
Epigenetics Podcast@epigeneticspod.bsky.social · 2y agoIn this episode of the Epigenetics Podcast, we talked with @evahoermanseder.bsky.social from @www.helmholtz-munich.de about her work on epigenetic mechanisms in cellular memory and gene regulation. #podcast #epigenetics Listen here: activemotif.com/podcasts-eva...
🚨NEW PAPER ALERT! 3 of our teams at IES collaborated to understand why some cells reprogram effectively while others fail @hamperllab.bsky.social @antonio-scialdone.bsky.social @evahoermanseder.bsky.social Congrats to all the authors of this exceptional paper published @stemcellreports.bsky.social
Helmholtz Munich@helmholtzmunich.bsky.social · 2y agoCell Fate Changes – Transcriptional Memory in Reprogramming Dr. Eva Hörmanseder, #HelmholtzMunich & team uncovered why some cells resist reprogramming – a key hurdle for regenerative medicine. 👉 t1p.de/43yrw @epihmgu.bsky.social #CellReprogramming #Epigenetics #StemCells #RegenerativeMedicine
🚨New preprint from @bonevlab.bsky.social 🚨: What are the key epigenetic mechanisms that drive species-specific gene regulation during primate neurogenesis - and how do they contribute to the evolution of the human neocortex? Here’s what we discovered 👇 www.biorxiv.org/content/10.1...
3D Epigenome Evolution Underlies Divergent Gene Regulatory Programs in Primate Neural Development
The expansion of the neocortex is a hallmark of human evolution and is closely linked to neural stem cell biology. Yet, the epigenetic mechanisms driving divergent gene regulation during primate neuro...
biorxiv.org
Very happy to share the preprint of my main PhD project in the @bonevlab.bsky.social! Huge thanks to @boyanbonev.bsky.social, all co-authors and members of the @bonevlab.bsky.social! This work wouldn’t have been possible without your contributions!
Boyan Bonev@boyanbonev.bsky.social · 2y ago🚨New preprint from @bonevlab.bsky.social 🚨: What are the key epigenetic mechanisms that drive species-specific gene regulation during primate neurogenesis - and how do they contribute to the evolution of the human neocortex? Here’s what we discovered 👇 www.biorxiv.org/content/10.1...
The last chapter of my PhD is finally out! Huge thanks to my supervisor @genikhovich.bsky.social for supporting “at first glance, stupid ideas” — which turned into a nice paper! That was so much fun!
genikhovich.bsky.social
Evolution of developmental mechanisms, especially axial patterning. Experimental embryology. 🪸🪼
genikhovich.bsky.social
@genikhovich.bsky.social · 2y agoTanya's @tclebedeva.bsky.social paper on endomesoderm specification in the beta-catenin-negative area of the Nematostella embryo is out! www.nature.com/articles/s41...
Thank you Antonio for this great collaboration!
Antonio Scialdone@antonio-scialdone.bsky.social · 2y agoWhy do some cells resist nuclear reprogramming? Using nuclear transfer, we tracked single-cell fate changes in vivo and uncovered cell-type-specific barriers to reprogramming. Suppressing the old identity boosts success! www.cell.com/stem-cell-re...
