Decima learns to predict cell-type-specific gene expression based on DNA sequences. @avantikalal.bsky.social www.nature.com/articles/s41...

Decoding sequence determinants of gene expression in diverse cellular and disease states - Nature Methods

Decima learns to predict cell-type-specific gene expression based on DNA sequences, contributing to the analysis of gene regulation and design of context-specific regulatory elements.

nature.com

Last call for our open Group Leader position at VIB.AI and Ghent University! Focus: AI in (bio)medicine Don’t miss this opportunity 👉 https://vib.ai/en/group-leader-vacancy

Which active learning methods are best for genomics models? See Rafi's thread on our recent preprint, below. www.biorxiv.org/content/10.6... Rafi is having a good week - he's got one more preprint to post!

Abdul Muntakim Rafi@muntakimrafi.bsky.social · 2mo ago

1/14 Sequence-to-expression (S2E) models keep getting better at reading cis-regulatory logic. But they haven't solved it. On tasks like variant effect prediction they're still far from accurate. Remember, solving cis-regulation is the goal and we're not going to settle for less!

Our Decima paper is now published in Nature Methods! Full text: rdcu.be/fkASS. Decima can predict gene expression in specific cell types and cell states from DNA sequence. I would say more but @drkbio.bsky.social and Johannes Linder wrote this great news & views: www.nature.com/articles/s41...

Decoding sequence determinants of gene expression in diverse cellular and disease states

Nature Methods - Decima learns to predict cell-type-specific gene expression based on DNA sequences, contributing to the analysis of gene regulation and design of context-specific regulatory elements.

rdcu.be

#MLCB2026 will be November 16-17 at (once again) @nygenome.org, NYC! Paper/abstract deadline is July 1st, more deets at mlcb.org. We'll be opening in-person registration alongside paper decisions. Mailing list to stay in the loop: groups.google.com/g/mlcb. Keynotes TBA! Please RP!

Agents for comp bio are advancing rapidly, but evals are lagging. Current benchmarks can be overly prescriptive. Full analysis vignettes are hard to verify. We introduce CompBioBench: 100 diverse, challenging, verifiable tasks. We benchmark Codex and Claude Code. biorxiv.org/content/10.6... 1/9

AITHYRA is recruiting a LIFE SCIENCE PI We are interested in research questions related to one of our four core disease areas: cancer research, immunological disorders, infectious diseases, neurodevelopment disorders. Job Ad: aithyra.at/fileadmin/do... Apply by 30.4.2026 #StartingPI #LS #AITHYRA

AITHYRA is recruiting an AI/ML STARTING PI Generative Models, Large Language Models, Agentic AI, Active & Reinforcement Learning, AI-driven Scientific Discovery & Lab Automation, ML-driven molecular simulations... Job Ad: aithyra.at/fileadmin/do... Apply by 30.4.2026 #StartingPI #AI/ML #AITHYRA

🧬 We're hiring scientists! I'm building a new team at the Generative Biology Institute, Ellison Institute of Technology Oxford, next to colleagues in AI, Robotics, and Plant Biology.

The @steinaerts.bsky.social lab is looking for a postdoctoral researcher to develop next-generation sequence-to-function models for glioblastoma, one of the most aggressive brain cancers. More info & how to apply 👉 https://vib.ai/en/opportunities#/job-description/130090

Highlighting two manuscript additions: 1. Data ablation (Supp. Fig 12): RNA-seq + ATAC/DNase proved essential for key evals. h/t @anshulkundaje.bsky.social for the suggestion! 2. Variant Analysis: We found evidence to upgrade a 3’ UTR VUS from Ellingford et al 2022 to "likely pathogenic."

AlphaGenome is out in @nature.com today along with model weights! 🧬 📄 Paper: www.nature.com/articles/s41... 💻 Weights: github.com/google-deepm... Getting here wasn’t a straight path. We discussed the story behind the model, paper & API in the following roundtable: youtu.be/V8lhUqKqzUc

Please consider attending and RT. Great lineup of speakers!

Stowers Institute@stowersinstitute.bsky.social · 8mo ago

Registration is OPEN for #SRCKC26: Development, Regulatory Genomics & AI! Organized by Neşet Özel, @juliazeitlinger.bsky.social, & @saukaspengler.bsky.social. Join us April 22–24 in #KansasCity to explore cis-regulatory logic, genomics & #AI. 📅 Register now: bit.ly/4rMvVoI

🎄 We’re hiring in Health AI at @HelmholtzMunich! 🔹 PIs in Health AI/AI Foundations 🔹 Health AI Fellows 🔹 Clinical AI Consultants Apply👇 PIs: jobs.helmholtz-muenchen.de/jobposting/8... Fellows: jobs.helmholtz-muenchen.de/jobposting/7... Consult: jobs.helmholtz-muenchen.de/jobposting/c...

Principal Investigators (f/m/x) for (i) AI in Biomedicine and (ii) AI Foundations

At Helmholtz Munich, we develop groundbreaking solutions for a healthier society in a rapidly changing world. We believe that diverse perspectives drive innovation. Through strong partnerships, we…

jobs.helmholtz-muenchen.de

AITHYRA Global Adjunct Principal Investigator Program: Advancing AI-Driven Life Science Through Global Collaborations Learn more about the Program: aithyra.at/fileadmin/do... Application Deadline, 30 January 2026: application@aithyra.at #AITHYRA #GlobalAdjunctPI

After a huge amount of work w/ @alex-stark.bsky.social's group, a new version of our Ledidi preprint is now out! In an era of AI-designed proteins, the next leap will be controlling when, where, and how much of these proteins are expressed in living cells. www.biorxiv.org/content/10.1...

Programmatic design and editing of cis-regulatory elements

The development of modern genome editing and DNA synthesis has enabled researchers to edit DNA sequences with high precision but has left unsolved the problem of designing these edits. We introduce Le...

biorxiv.org

We are hiring a PhD intern for Summer 2026 in ML for regulatory genomics at ReLU/BRAID/Genentech! Work on DNA sequence models for the noncoding genome (e.g. DNA design, models of MPRA and genetic variants)! 🥳

2026 Summer Intern - Biology Research | AI Development in South San Francisco, California, United States of America | Students & Graduates at Genentech

Apply for 2026 Summer Intern - Biology Research | AI Development job with Genentech in South San Francisco, California, United States of America. Students & Graduates at Genentech

lnkd.in

And finally, we have a postdoc opening in our team. You’ll get to work on cutting edge models while gaining a unique perspective on how these tools can shape the future of AI in genomics. Join us! 15/15 careers.gene.com/us/en/job/20...

Postdoctoral Fellow - Regulatory Language Understanding (ReLU) Lab in South San Francisco, California, United States of America | Students & Graduates at Genentech

Apply for Postdoctoral Fellow - Regulatory Language Understanding (ReLU) Lab job with Genentech in South San Francisco, California, United States of America. Students & Graduates at Genentech

careers.gene.com

Excited to share Nona: a unifying multimodal masking framework for functional genomics. Models for DNA have evolved along separate paths: sequence-to-function (AlphaGenome), language models (Evo2), and generative models (DDSM). Can these be unified under a single paradigm? 1/15

The Starting Principal Investigators at #AITHYRA the Research Institute for Biomedical Artificial Intelligence of the OeAW in Vienna invite outstanding candidates to apply for postdoctoral positions in the field of AI/ML & Life Sciences. www.oeaw.ac.at/aithyra/post... Please apply by 20 Nov 2025!

🚨 Exciting opportunity! The Eric and Wendy Schmidt Center at the Broad Institute of MIT and Harvard is recruiting exceptional postdocs for 2026 at the intersection of ML/math and biomedicine. Shape the future of computational biology 🧵👇

gReLU advances deep learning based modeling and analysis of DNA sequences with comprehensive toolsets and versatile applications. @avantikalal.bsky.social @gokcen.bsky.social www.nature.com/articles/s41...

gReLU: a comprehensive framework for DNA sequence modeling and design - Nature Methods

gReLU advances deep-learning-based modeling and analysis of DNA sequences with comprehensive toolsets and versatile applications.

nature.com

My team has a postdoc position available now, join us! careers.gene.com/us/en/job/20...

I'm happy to share that our gReLU package is now published in Nature Methods! www.nature.com/articles/s41...

gReLU: a comprehensive framework for DNA sequence modeling and design - Nature Methods

gReLU advances deep-learning-based modeling and analysis of DNA sequences with comprehensive toolsets and versatile applications.

nature.com

We have a postdoc position in my team. Join us if you are passionate about genomics, human genetics, synthetic biology and agentic AI! careers.gene.com/us/en/job/20...

I’ll be in Boston for #ASHG25 next week and am looking forward to meeting everyone! Please ping me if you want to catch up, or catch me after my talk on Thursday morning (It’s the first thing on Thursday morning. I’m sure you all will be awake)

Now that I'm settled in at @umasschan.bsky.social, I'm hiring at all levels: grad students, post-docs, and software engineers/bioinformaticians! The goal of my lab is to understand the regulatory role of every nucleotide in our genomes and how this changes across every cell in our bodies.

Open rank tenure-track position in comp bio at the University of Montreal. Great environment, great position. @futurepislack.bsky.social medecine.umontreal.ca/wp-content/u...

Are you an AI expert who wants to stay in academia and change the world by understanding the most complex things we know - living organisms? Want to lead your own group, based in Heidelberg DE, working language English? @embl.org is hiring in AI embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Group Leader – AI in Biology

Are you ready to lead groundbreaking research in AI for Biology? Join us at EMBL! We are seeking a visionary scientist to establish their own independent research group bridging innovations in machine...

embl.wd103.myworkdayjobs.com

We have an exciting new opportunity for a postdoc in our team at Genentech! Please share.

My team has a postdoc position available now, join us! careers.gene.com/us/en/job/20...