🚨New preprint alert 🚨 "Pancreatic cancer cells breach endothelial barriers through protrusion-driven invasion or endothelial retraction" www.biorxiv.org/content/10.6...

💥finally here💥. Our latest manuscript (@goetzjacky.bsky.social lab) is out in @natmater.nature.com. We show that cell viscosity drives the metastatic potential. A project handled by former PhD student Valentin Gensbittel, help from Zeynep Yesilata & many labmates! www.nature.com/articles/s41...

Cell viscosity influences haematogenous dissemination and metastatic extravasation of tumour cells - Nature Materials

The viscosity of tumour cells is shown to govern their ability to disseminate through the bloodstream and extravasate, establishing a key biomechanical factor of metastasis.

nature.com

Naël Osmani@naelosmani.bsky.social · last yr.

🎉Beyond happiness... this was a long story ! Well handled by our former PhD student Valentin Gensbittel. Initiated back when I was a post doc and now finalized as a tenured researcher in @goetzjacky.bsky.social lab ! If you can't wait the initial version is still here www.biorxiv.org/content/10.1...

Delighted to share the latest paper from the lab "Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers" Amazing work driven by @follainga.bsky.social with contributions from many. link.springer.com/article/10.1...

Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers - The EMBO Journal

The rapid, transient, and unpredictable nature of interactions between circulating cells and the endothelium challenges the investigation of these events under flow conditions. Here, we developed an i...

link.springer.com

Our newest paper is out in NCB. @jrwconway.bsky.social‬ designed a new FRET reporter, Illusia, to show the importance of integrin β1 phosphorylation dynamics in 3D invasion! Video: TNBC cells expressing Illusia with a Src (Saracatinib) or SHP2 (SHP099) inhibitor. www.nature.com/articles/s41...

New paper from @ivaskalab.bsky.social out now! 🍾 Watch how cancer cell adhesion dynamics are disrupted by inhibiting the phosphatase Shp2 - key to integrin β1 phosphorylation. Blocking Shp2 impairs adhesion and reduces invasion potential. 🎥👇 Read more at: www.nature.com/articles/s41...

Can't wait to be in Italy for GRS/GRC...! 🥶 Fibronectin, Integrins and Related Molecules www.grc.org/fibronectin-... I'll present our preprint and more on extravasation of PDACs. :)

We wrote a small Viewpoint for Molecular Oncology with @follainga.bsky.social @omkarjoshi.bsky.social Michal Dibus via EACR @helloeacr.bsky.social Time, the final frontier febs.onlinelibrary.wiley.com/doi/full/10.... Hope you find it interesting

Trying something new: For our recent preprint: Fast label-free live imaging reveals key roles of flow dynamics and CD44-HA interaction in cancer cell arrest on endothelial monolayers www.biorxiv.org/content/10.1... I made an online presentation: www.beautiful.ai/player/-ODGe...

Fast label-free live imaging reveals key roles of flow dynamics and CD44-HA interaction in cancer cell arrest on endothelial monolayers

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Introductory post on 🦋! We're a research group headed by Prof. Johanna Ivaska interested in understanding how integrins contribute to every step of cancer progression. We're located at the Turku Bioscience Center in Turku, Finland! Find out more about us and our interests here: ivaskalab.utu.fi

Ivaska cell adhesion and cancer Lab

Integrins, matrix, motility and mechanotransduction in cancer

ivaskalab.utu.fi