Our paper on longitudinal multi-omics in an ageing population is out at @science.org Led by @juliaelsayed.bsky.social, we profiled gene expression and metabolomics at 3 timepoints in 335 individuals over 6-8 years to investigate molecular ageing trajectories www.science.org/doi/10.1126/...

Longitudinal dynamics of gene expression and metabolomics in an aging population cohort

Multiomic profiling provides a comprehensive physiological overview at the molecular level, but understanding of its spatiotemporal dynamics remains limited in human populations. We profiled longitudi...

science.org

🧬 New today! 📄 Higher eQTL power reveals signals that boost GWAS colocalization 🧑‍🤝‍🧑 @mikelove.bsky.social @klmohlke.bsky.social & colleagues

Higher eQTL power reveals signals that boost GWAS colocalization

Rosen et al. quantify how eQTL study sample size influences signal discovery and GWAS colocalization. Integrating evidence from recent eQTL studies, they show that limited statistical power influences...

cell.com

We’re launching a King’s Prize Doctoral Training Programme in Genome Data Science & AI for Therapeutic Target Discovery. Train with world-leading academic & industry partners to use human genetics & AI to uncover disease mechanisms & new drug targets. Apply by 28th Feb. www.kcl.ac.uk/research/tar...

Genome Data Science and AI for Therapeutic Target Discovery - King’s Prize Doctoral Programme | King's College London

PhD programme in human genetics, AI and multi-omics to uncover causal biology and accelerate therapeutic target discovery with academic and industry partners.

kcl.ac.uk

Group leader positions available in Dept. of Medical and Molecular Genetics at King's College London (from lecturer to professor) - an exciting opportunity to join a thriving human genetics community and build something brilliant! www.kcl.ac.uk/jobs/134827-...

Academic position in Human Genetics and Genomics | King's College London

kcl.ac.uk

Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...

Somatic mutation and selection at population scale - Nature

A new version of nanorate DNA&nbsp;sequencing, with an&nbsp;error rate&nbsp;lower than five errors&nbsp;per billion base pairs&nbsp;and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection&nbsp;and&nbsp;the generation of high-resolution&nbsp;selection&nbsp;maps across coding and non-coding sites for many genes.

nature.com

Now published! Our paper on: (1) Accurate sequencing of sperm at scale (2) Positive selection of spermatogenesis driver mutations across the exome (3) Offspring disease risks from male reproductive aging [1/n] www.nature.com/articles/s41...

Sperm sequencing reveals extensive positive selection in the male germline - Nature

A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.

nature.com

New Postdoc Opportunity @ KCL! 🧬 Explore X-inactivation, methylation, and sex differences in depression 🧠 Work with a brilliant team at the SGDP Centre 📍 Denmark Hill, London 🗓️ Deadline: 26 Sept 🔗 www.kcl.ac.uk/jobs/124665-... #AcademicJobs #Postdoc #Genetics #MentalHealth

📣📣 New postdoc in biomedical data science available in our lab!! www.jobs.cam.ac.uk/job/50966/ Flexible funding - many research areas in scope + ideas welcome Check out our group www.inouyelab.org/home And the awesome Cambridge research environment! @vpd-hlri.bsky.social @uniofcam.bsky.social

Nice to see recent author Christopher Shore featured in the @geneticssociety.bsky.social Trainee Excellence Spotlight!

Trainee Excellence Spotlight: Christopher Shore

Trainee Excellence Spotlight, TES, Trainee, Spotlight, ASHG, American Society for Human Genetics, Genetics

ashg.org

We have an open position to do a #PhD in genomics at the University of Dundee (UK). This is a 4 years fully funded position in collaboration with pharma industry in USA. Unfortunately, only for UK citizens or pre- and settle status residents. Please share! shorturl.at/RwaCr

Interaction of genetic and environmental drivers of metabolic and autoimmune disease at University of Dundee on FindAPhD.com

PhD Project - Interaction of genetic and environmental drivers of metabolic and autoimmune disease at University of Dundee, listed on FindAPhD.com

findaphd.com

Very excited to share that our manuscript on cis-eQTL analysis of adipose tissue gene expression in 2,344 samples is now out in Nature Genetics rdcu.be/d5ov4 See thread from lead author @sarahbrotman.bsky.social‬ below

Adipose tissue eQTL meta-analysis highlights the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits

Nature Genetics - This study introduces AdipoExpress, an eQTL meta-analysis of 2,344 subcutaneous adipose tissue samples, which triples the size of previous studies and expands the discovery of...

rdcu.be

Sarah Brotman@sarahbrotman.bsky.social · 2y ago

I’m excited to share that this manuscript is now published in Nature Genetics! 🧪🧬 🖥️ www.nature.com/articles/s41... The AdipoExpress data can be accessed here: zenodo.org/records/1384... An interactive browser of the colocalization results can be accessed here: adipose.colocus.app

🌟 Exciting news: The Leena Peltonen School of Human Genetics returns in 2025! We're excited to bring PhD students together with an all-star list of leaders in human genetics. 📅 July 27-31, 2025 📍 Wellcome Genome Campus, UK 📝 Apply by March 7 at www.lpshg.com

Resharing here a recent X post. In this preprint, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/ www.medrxiv.org/content/10.1...

Somatic mutation and selection at epidemiological scale

As we age, many tissues become colonised by microscopic clones carrying somatic driver mutations ([1][1]–[10][2]. Some of these clones represent a first step towards cancer whereas others may contribu...

medrxiv.org

I am excited to share our preprint describing a collaborative effort to identify conditionally distinct signals in the largest adipose eQTL dataset to date (AdipoExpress). @kerrinsmall.bsky.social @klmohlke.bsky.social Laura Scott, and others 🧪🧬 🖥️ #GeneSky 1/8 www.biorxiv.org/content/10.1...