Spatial transcriptomics maps host–gut microbiome biogeography at high resolution www.nature.com/articles/s41... @natmicrobiol.nature.com @dwmckellar.bsky.social @ntekasi.bsky.social

Our work with Lena Takayasu and @dwmckellar.bsky.social in Iwijn De Vlaminck's lab is now out in @natmicrobiol.nature.com ! 🎉 Spatial transcriptomics maps host–gut microbiome biogeography at high resolution rdcu.be/e7i7o

Still time to sign up for this event next week! So far, across the ~120 registrants we have 7 academic institutions, 4 companies, and 2 journals represented!

David McKellar@dwmckellar.bsky.social · last yr.

Very excited to announce the first **RNA x Tech Dev Mini-Symposium** in collab with the Tri-I RNA Club! Talks from Chris Mason, Ildar Gainetdinov, @xuebingwu.bsky.social, and Sanja Vickovic! Come down to @nygenome.org and hear about the latest in RNA technology development being done in NYC!

Not a bad spot to talk science...

Very excited to announce the first **RNA x Tech Dev Mini-Symposium** in collab with the Tri-I RNA Club! Talks from Chris Mason, Ildar Gainetdinov, @xuebingwu.bsky.social, and Sanja Vickovic! Come down to @nygenome.org and hear about the latest in RNA technology development being done in NYC!

Happy Single-Cell Genomics Day! #SCGD25 satijalab.org/scgd25/

A window into the future of diagnostics from one of my favorite scientists, @alexpellancheng.bsky.social. Awesome work!

Alex@alexpellancheng.bsky.social · last yr.

What happens when sequencing costs go ⏬ ? Imagination and new opportunities go ⏫ @landau.bsky.social Let's look at what you can do when you perform deep WGS on cfDNA for cancer detection. Our recent work with the @UltimaGenomics platform 🧵👇 Lets goooo!! rdcu.be/ehkUb

Very cool work from the team at Kanvas on HiPR-Map! www.biorxiv.org/content/10.1...

Multiscale Spatial Mapping of Microbial Communities for Biotherapeutic Development

Live biotherapeutic products (LBPs) are emerging as powerful tools to modulate the microbiome using well-defined microbial communities. Yet, designing, manufacturing, and delivering LBPs remains chall...

biorxiv.org

Designing/building a Toyota is just as hard as a designing/building Ferrari in biology

Igor Ulitsky@igorulitsky.bsky.social · last yr.

Many highly cited experimental methods are methods that sound useful but hard/impossible to implement successfully. Many highly cited computational studies are for methods that have implementation but actually don't work well (or are just slow), giving an excellent benchmark for others.

📢New Yorkers! We're meeting for the second session of the 'Postdoc Night Science NYC' club on January 30th 5-7pm. This time we'll be at NYU (Washington Square campus), with the topic of 'A hypothesis is a liability'. Space is limited so please register: docs.google.com/forms/d/1Shc...

And without further ado, the top muscle paper for 2024 as voted on by you is: 1. Sequeira et al., Dev. Myonuclear position and blood vessel organization during skeletal muscle postnatal development. tinyurl.com/bduvtpa8

Myonuclear position and blood vessel organization during skeletal muscle postnatal development

Summary: A comprehensive analysis of the first 20 days of mouse skeletal muscle postnatal development focusing on myonuclear positioning and interactions of myonuclei with blood vessels.

tinyurl.com

Delighted to share new work from our lab: MultiPerturb-seq 🎛️ ❌ ↕️ Over the last few years, we've been combining CRISPR screens with multimodal readouts of gene expression (RNA) and chromatin accessibility (DNA). In this study, we bring those together within the same cells.

Nature Biotechnology@natbiotech.nature.com · 2y ago

Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling go.nature.com/4hXER5O

Come talk RNA with us!

Naama Aviram@naamaaviram.bsky.social · 2y ago

#RNA enthusiasts in the NYC area? Come join us for the Tri-I RNA Club Winter Mini-Symposium! We’ll have great talks by trainees, followed by some food and drinks. Hope to see you there! #RNAsky #RNAbiology

Spatial structure shapes the host-microbiome interactome. Our new method to map the host-microbiome interface at high-resolution, now on bioRxiv! Co-led with Lena Takayasu & @dwmckellar.bsky.social collab between the De Vlaminck and Brito labs doi.org/10.1101/2024... A thread⬇️

High Resolution Spatial Mapping of Microbiome-Host Interactions via in situ Polyadenylation and Spatial RNA Sequencing

Inter–microbial and host–microbial interactions are thought to be critical for the functioning of the gut microbiome, but few tools are available to measure these interactions. Here, we report a metho...

doi.org