We made it to the front of @natmicrobiol.nature.com 🤯 In this case, judging by the cover is encouraged Spatial transcriptomics maps host–gut microbiome biogeography at high resolution

Spatial transcriptomics maps host–gut microbiome biogeography at high resolution

Nature Microbiology - Bulk polyadenylation improves the capture of microbial RNA, enabling host–microorganism interactions to be visualized at a high resolution when combined with...

rdcu.be

Nature Microbiology@natmicrobiol.nature.com · 3mo ago

Our May issue with a focus on technological advances in microbiology is out now! Read about 🌱defence evasion by plant pathogens 🦠E. coli capsule revival 💻multiomic microbiome integration 🐁chronic chikungunya infection 🦀 bacteria in cancer immunotherapy and much more: shorturl.at/Wtzkp #MicroSky

Interested in teaching your kids or students about bacteria and how they interact to collectively respond to antibiotics? The @sj4k.bsky.social worked with us to adapt our recent paper into an article to help teens think about social interactions in bacterial communities:

How do bacteria protect each other from antibiotics? - Science Journal for Kids and Teens

Researchers show how bacteria living close together form patterns, share protection, and respond to antibiotics in surprising ways.

sciencejournalforkids.org

Thank you for highlighting our work!

Kevin Bonham@kevinbonham.com · 4mo ago

On the latest episode of @audiommunity.org , @woodrufflab.bsky.social and I talk through this wonderful new paper. A conceptually straightforward advance that massively expands the usefulness of this is kind of spatial 'omics 🧪

Spatial Gut-Microbiome MegaTranscriptomics Use in situ polyadenylation on #Visium #StereoSeq to enhance host & bacterial RNA recovery (⏫99-fold) Fresh-frozen🐭GI Non-coding RNAs enriched to gut wall Microorganisms enriched at CRC tumor boundary #NatMicrobiol 2026 www.nature.com/articles/s41...

Out Now! Spatial transcriptomics maps host–gut microbiome biogeography at high resolution #MicroSky

Spatial transcriptomics maps host–gut microbiome biogeography at high resolution

Nature Microbiology, Published online: 06 March 2026; doi:10.1038/s41564-026-02286-7Bulk polyadenylation improves the capture of microbial RNA, enabling host–microorganism interactions to be visualized at a high resolution when combined with commercially available spatial transcriptomics platforms.

go.nature.com

Our work with Lena Takayasu and @dwmckellar.bsky.social in Iwijn De Vlaminck's lab is now out in @natmicrobiol.nature.com ! 🎉 Spatial transcriptomics maps host–gut microbiome biogeography at high resolution rdcu.be/e7i7o

Spatial transcriptomics maps host–gut microbiome biogeography at high resolution www.nature.com/articles/s41... @natmicrobiol.nature.com @dwmckellar.bsky.social @ntekasi.bsky.social

I wrote about the recent autism-microbiome paper, why I think it's the most important microbiome paper this year, and what it says about the field open.substack.com/pub/blekhman...

The Autism-Microbiome Hypothesis Is Falling Apart

Why this new review paper should be required reading for every microbiome researcher

open.substack.com

Introducing Foli-seq in @natbiotech.nature.com today. Foli-seq can be used to measure gut-derived RNA from fecal matter (signals of immune, secretory & epithelial cells). We used this to map gut inflammation, drug response, and host-microbe interactions. 💩🧬💊🦠 www.nature.com/articles/s41...

Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut - Nature Biotechnology

Profiling host RNA shed in feces reveals disease states in the gut.

nature.com

Another banger from the @harriswang.bsky.social Lab this month! “Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut” www.nature.com/articles/s41...

Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut - Nature Biotechnology

Profiling host RNA shed in feces reveals disease states in the gut.

nature.com

Exciting discovery by Svensson lab and collaborators @stanfordmedicine.bsky.social, computational discovery of 2500 new bioactive peptides, including 12-mer named BRP that reduces food intake leading to weight loss w/o nausea in mice! www.nature.com/articles/s41...

Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide - Nature

Computational drug discovery is used to identify a 12-mer peptide derived from BRINP2 with potent anti-obesity effects that are independent of leptin, glucagon-like peptide 1 receptor and melanocortin...

nature.com

Contributions from: Jeffrey Moffitt, @drmingyaoli.bsky.social, Qing Nie, Kazumasa Kanemaru, Sarah Teichmann, Daniel Dar, @ltkagohara.bsky.social, Shalev Itzkovitz, Roser Vento-Tormo, @fertiglab.bsky.social, @fabiantheis.bsky.social

Tabula Sapiens reveals transcription factor expression, senescence effects, and sex-specific features in cell types from 28 human organs and tissues https://www.biorxiv.org/content/10.1101/2024.12.03.626516v1

Tabula Sapiens reveals transcription factor expression, senescence effects, and sex-specific features in cell types from 28 human organs and tissues https://www.biorxiv.org/content/10.1101/2024.12.03.626516v1

The Tabula Sapiens is a reference human cell atlas containing single cell transcriptomic data from m

biorxiv.org

New research from the Xavier lab at Broad reveals the gut's adaptability and immune-driven control in specific regions. A spatial map of the mouse intestines highlights its resilience to perturbations like inflammation, with implications for understanding diet, food allergies, and IBD in humans 🧬🦠

Broad Institute@broadinstitute.org · 2y ago

The intestine maintains a delicate balance in the body. This equilibrium is disrupted in parts of the organ in some diseases, but scientists don’t fully understand why. Now, researchers have created a blueprint of the gut that could address these questions. #science @natureportfolio.bsky.social

Spatial structure shapes the host-microbiome interactome. Our new method to map the host-microbiome interface at high-resolution, now on bioRxiv! Co-led with Lena Takayasu & @dwmckellar.bsky.social collab between the De Vlaminck and Brito labs doi.org/10.1101/2024... A thread⬇️

High Resolution Spatial Mapping of Microbiome-Host Interactions via in situ Polyadenylation and Spatial RNA Sequencing

Inter–microbial and host–microbial interactions are thought to be critical for the functioning of the gut microbiome, but few tools are available to measure these interactions. Here, we report a metho...

doi.org