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Björn Rissiek

@brissiek.bsky.social

Immunologist at the Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf in Hamburg, Germany. Does Nanobody Discovery, interested in neuroinflammation and purinergic signalling. My opinion are my own.

35 Posts651 Follower1568 Folgt
Björn Rissiek@brissiek.bsky.social · 2mo ago

Great news: Our project „ARCH – Alpaca Repertoire Collection of HCAbs“ has been awarded funding through the UKE 3R program. Over the next two years, we will visit alpaca farms across Germany to collect blood and establish a naïve VHH library as a longterm 3R resource for nanobody discovery. #3R #VHH

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Björn Rissiek@brissiek.bsky.social · 8mo ago

Last year, my group launched a project funded by the T. von Zastrow Foundation that truly took all of us into new territory: the establishment of our own #Nanobody Discovery Platform. We genuinely started from scratch – including setting up our own alpaca facility with five female alpacas…

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Björn Rissiek@brissiek.bsky.social · 10mo ago

Yesterday, our first immunization campaign finished. We started late (and finished at 2:00 am 🤯) but everything went well. Lots of PBMCs and good RNA yield 🥳. Big thx to our campaign front runners Gaby 🦙 and Justy 🦙

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Björn Rissiek@brissiek.bsky.social · 10mo ago

Fantastic study by Michelle Jäckstein and Jörg Heeren of #SFB1328. Only the inhibition of both - #P2X7 and #P2X4 - protects from BAT inflammation!!! It was a pleasure to collaborate! Hope this inspires others to check P2X4/P2X7 double inhibition in their models! www.embopress.org/doi/full/10....

Purinergic adipocyte-macrophage crosstalk promotes degeneration of thermogenic brown adipose tissue | EMBO reports

imageimageStressed brown adipocytes release extracellular ATP, which acts as a paracrine signal via P2X4 and P2X7 receptors on macrophages, initiating BAT inflammatory remodeling and degeneration. Blocking this purinergic signaling axis prevents ...

embopress.org

Björn Rissiek@brissiek.bsky.social · last yr.

Our alpaca mares have their summer coat since yesterday. Ethics are approved, antigen production is ongoing, and we hope to start the first round of immunization in July. Super excited!!! 🦙🧬🔬👨‍🔬

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Björn Rissiek@brissiek.bsky.social · last yr.

I am happy to report that our chapter on "Flow Cytometric Analysis of Mouse Brain CD8+ T Cell Activation" is out now! It is part of a book on "T cell activation" curated and edited by Björn-Philipp Diercks of #sfb1328 link.springer.com/protocol/10....

Flow Cytometric Analysis of Mouse Brain CD8+ T Cell Activation

Cytotoxic CD8+ T cell lymphocytes are pivotal for fighting infections with intracellular pathogens, e.g., viruses. Moreover, recent studies have elucidated the role of CD8+ T cells in various neuroinf...

link.springer.com

Jamie Daw@jamiedaw.bsky.social · 2y ago

I received one of the 232 NIH grant "terminations" sent to scientists at Columbia last night. My research focuses on improving maternal and child health in the US. Also affected: ongoing clinical trials, research training programs, and research centers that aim to improve the health of Americans.

Hundreds of research grants at Columbia canceled following Trump edict, administrator says

The National Institutes of Health is terminating 232 grants for scientific research at Columbia University Irving Medical Center, according to an email an administrator sent to faculty.

gothamist.com

Dr. Lucky Tran@luckytran.com · 2y ago

Texas measles outbreak update: 124 cases, 18 hospitalized, & now the first death of a child, who was not vaccinated. Tragic, preventable, & a direct consequence of the deadly lies spread by anti-vaxx grifters, one of whom is now the most powerful health official in the US.

Texas announces first death in measles outbreak The Texas Department of State Health Services is reporting the first death from measles in the ongoing outbreak in the South Plains and Panhandle regions. The school-aged child who was not vaccinated was hospitalized in Lubbock last week and tested positive for measles. As of Feb. 25, 124 cases of measles have been confirmed in the outbreak since late January. Most of the cases are in children. Eighteen people have been hospitalized over the course of the outbreak.
Victor J. Torres@torreslab.bsky.social · 2y ago

Come and join our team at St. Jude Children's Research Hospital! We are seeking a Sr Scientist to advance our research on immune responses to infection/vaccination. This is a financially stable position offering a highly competitive salary and excellent benefits. talent.stjude.org/careers/jobs...

Senior Scientist-Immunology, Vaccinology, Infection in Memphis, Tennessee | St. Jude Careers

St. Jude Careers is hiring a Senior Scientist-Immunology, Vaccinology, Infection in Memphis, Tennessee. Review all of the job details and apply today!

talent.stjude.org

Delthia Ricks@dricks.bsky.social · 2y ago

New approach: Nanobody inhibitors that target Ebolavirus are under development at Univ of Minnesota. Nanobodies are tiny antibodies from animals like alpacas allowing access to viral regions too small for larger antibodies. This one blocks EBV's ability to enter human cells phys.org/news/2025-01...

Scientists develop nanobody inhibitors to target deadly Ebola virus

Ebola virus, one of the deadliest pathogens, has a fatality rate of about 50%, posing a serious threat to global health and safety. To address this challenge, researchers at the University of Minnesot...

phys.org