Genome-wide association analyses identify risk variants for borderline personality disorder and find genetic correlations with psychiatric disorders, behavioral traits and somatic diseases, according to a paper in Nature Genetics. go.nature.com/3Tlk0Bx 🧬🧪

This has been a long time in the making: Our genome-wide association study (GWAS) of borderline personality disorder (BPD) is now out in Nature Genetics. www.nature.com/articles/s41... 1/7

The largest genetic analysis of borderline personality disorder identified 11 independent risk regions and nine candidate genes, using data from about 13,000 affected people and 1.1 million controls. doi.org/hcb6qq

Largest genetic analysis of borderline personality disorder identifies 11 risk regions and nine genes

An international team led by the Central Institute of Mental Health in Mannheim has presented the largest genome-wide association study on borderline personality disorder to date.

medicalxpress.com

🧪 Data from 12,339 people with borderline personality disorder powered the largest GWAS for the condition so far. They mapped 11 associated genomic locations, explaining about 17% of inherited risk. The strongest genetic correlation they found was with PTSD. 🧬💻

Huge study finds first genetic clues for borderline personality disorder

Largest genetic analysis of the condition so far finds 11 linked locations in the human genome.

nature.com

📢 New publication in @nathumbehav.nature.com from the PGC Anxiety Working Group: the largest GWAS of generalised anxiety symptoms to date, analysing ~700k across 14 cohorts. We found 74 genome-wide significant loci, 39 novel for anxiety.

Great new preprint by the @pgcgenetics.bsky.social Suicide Working Group, investigating shared and distinct genetic contributions to different suicidality phenotypes!!!

medRxivpreprint@medrxivpreprint.bsky.social · 3mo ago

Suicidality phenotypes reflect both shared and distinct genetic factors https://www.medrxiv.org/content/10.64898/2026.05.14.26353207v1

Come work with me and @dr-appie.bsky.social in Amsterdam!

Abdel Abdellaoui@dr-appie.bsky.social · 4mo ago

Me & @aysuo.bsky.social are hiring a postdoc to study gene–environment interplay in health & social inequalities 🧬 You'll analyze genomic data as part of a collaboration with Uppsala & Oslo at @amsterdamumc.bsky.social (NL) werkenbij.amsterdamumc.org/en/vacatures... Please RT for karma points ♥️

There is high symptom and genetic overlap across psychiatric conditions. @andrewgrotzinger.bsky.social et al. (2025) explored this using our #GWAS data of over 1 mil cases across 14 conditions. They assessed the genetic architecture and the functional roles of genes across these conditions.

🧵 New publication from the PGC Anxiety Working Group. Our GWAS meta-analysis of anxiety disorders is now published in @natgenet.nature.com! 🔗: doi.org/10.1038/s415...

New report by the PGC outreach committee: From Genomes to Conversations: Outreach and Engagement in Psychiatric Genetics (2026) An important contribution on why dialogue, and responsible communication must be integral to psychiatric genetics. link.springer.com/article/10.1...

From Genomes to Conversations: Outreach and Engagement in Psychiatric Genetics - Behavior Genetics

Outreach in psychiatric genetics bridges the gaps across research advancements, clinical practice, and public understanding. Effective communication with a range of audiences faces multiple challenges...

link.springer.com

My department @bsse.ethz.ch is inviting applications for a new assistant professor (tenure-track) in computational immunology, interested candidates please see advert and apply! Deadline 15 April 2026 ethz.ch/en/the-eth-z...

Assistant Professor (Tenure Track) of Computational Immunology

ethz.ch

Examining the Contribution of Childhood Maltreatment to the Gender Gap in Depression: Insights from the German National Cohort (NAKO) https://www.medrxiv.org/content/10.64898/2026.02.02.26345366v1

Happy to share our newest preprint! Depression is more common in females than in males, but it remains insufficiently understood why. Using data from the German National Cohort (NAKO) @nako.de, we investigated whether childhood maltreatment may contribute to this gender gap. doi.org/10.64898/202...

Examining the Contribution of Childhood Maltreatment to the Gender Gap in Depression: Insights from the German National Cohort (NAKO)

Background: Childhood maltreatment is a major risk factor for depression and may contribute to sex differences in depression prevalence. We examined sex-specific associations between childhood maltrea...

doi.org

Looking forward to it!

International Society of Psychiatric Genetics@ispg.bsky.social · 6mo ago

There's no other meeting like WCPG. Exciting news and important deadlines are on their way to you soon! #WCPG26 #ISPG #PsychiatricGenetics #Glasgow #Scotland

New paper out: Some people are systematically better at judging others’ intelligence. Who are the best judges? People WHO are intelligent themselves, have good emotion-perception ability, and who are high in well-being. www.sciencedirect.com/science/arti...

The good judge of intelligence

Accurately judging others' intelligence is important, yet little is known about individual differences in this ability. In this study we investigated …

sciencedirect.com

Happy to share this: we confirmed a significant link between smoking and depression using data from the @nako.de. Our analysis of over 170,000 participants shows that both current and former smokers face a higher lifetime risk of depression. #MentalHealth #ResearchNews #PublicHealth

NAKO Gesundheitsstudie (German National Cohort)@nako.de · 7mo ago

Scientists showed that depression was more common among current and former smokers than among never-smokers over the course of their lifetime. In addition, a dose-response relationship was observed. 👉 nako.de/en/press-rel...

Analysis of over 170,000 adults indicates that current and former smokers experience depression more frequently than never-smokers, with risk decreasing the longer a person has quit smoking. doi.org/hbk2gw

Link between smoking and depression confirmed in study

A research group led by the Central Institute of Mental Health (CIMH) in Mannheim has confirmed for the first time within the German National Cohort (NAKO) an association between cigarette consumption and depression.

medicalxpress.com

A very comprehensive review of the genetics of personlity led by @tedmond.bsky.social This is a great onramp for those who haven't checked into psychiatric genetics or bahviour genetics in a while. www.annualreviews.org/content/jour...

Personality Genomics

Recent research advances have precipitated the era of personality genomics: the study of how variation in human DNA sequence predicts individual differences in characteristic patterns of thinking, fee...

annualreviews.org

This is an interesting challenge, Its A LOT of data for psychology, but not for ML perse. I wonder whether there is juice to be squeezed out of other EMA data, which would only have partial feature overlap, loads of other EMA data lives here: openesmdata.org.

Eiko Fried@eikofried.bsky.social · 7mo ago

After 5 years of data collection, our WARN-D machine learning competition to forecast depression onset is now LIVE! We hope many of you will participate—we have incredibly rich data. If you share a single thing of my lab this year, please make it this competition. eiko-fried.com/warn-d-machi...

Want to make nice graphs with me, starting next year? I'm hiring for a position at the University of Witten/Herdecke. uni-wh.softgarden.io/job/61280592...

🚨New preprint from PGC SUI!! @pgcgenetics.bsky.social GWAS meta-analyses of suicidal ideation, attempt, death, and behavior across >50 cohorts identify 77 loci (59 novel), implicate subcortical brain regions, and show suicidality phenotypes are genetically distinct. www.medrxiv.org/content/10.1...

Genome-wide association studies identify 77 loci for suicidality and provide novel biological insights

Suicidality is heritable and a leading cause of global morbidity and mortality, yet its biological etiology remains largely elusive. We conducted multi-ancestry genome-wide association study meta-anal...

medrxiv.org

🧠 Why do some brains age faster than others? 🧬 Our new Nature Aging study of over 56,000 participants explores the genetics of the “brain age gap” — the difference between your brain’s biological and chronological age. nature.com/articles/s43587-025-00962-7 Thread below 👇

Genome-wide analysis of brain age identifies 59 associated loci and unveils relationships with mental and physical health - Nature Aging

This genomic study of magnetic resonance imaging-based brain age in 56,348 people identifies 59 genetic loci, links brain aging to mental and physical health, and suggests high blood pressure and type 2 diabetes as causal factors of brain aging.

nature.com

Breaking the Norm: Population-Scale Normative Modeling of Brain Structure in Depression and Anxiety https://www.medrxiv.org/content/10.1101/2025.09.26.25336528v1

Breaking the Norm: Population-Scale Normative Modeling of Brain Structure in Depression and Anxiety | medRxiv www.medrxiv.org/content/10.1...

The field of neuroscience views the goal of human genetics as "finding genes". This is an outdated view. In whole genome studies of rare variants, finding genes is the easy part. The more interesting and important goal is to map out the causal pathway from genes to brain function to cognitive traits

medRxivpreprint@medrxivpreprint.bsky.social · last yr.

A cross-disorder analysis of CNVs finds novel loci and dose-dependent relationships of genes to psychiatric traits https://www.medrxiv.org/content/10.1101/2025.07.11.25331310v1

Got prov. approval for 2 major grants in Neuro-AI & Dynamical Systems Reconstruction, on learning & inference in non-stationary environments, out-of-domain generalization, and DS foundation models. To all AI/math/DS enthusiasts: Expect job announcements (PhD/PostDoc) soon! Feel free to get in touch.

I’m excited to share our genetic study on panic disorder in the FinnGen sample. We found a genomewide significant hit within the SORCS3 gene and showed that SORCS3 serum protein levels were 40% higher in panic disorder patients compared to controls medrxiv.org/cgi/content/...

Genome-wide Association Study Identifies SORCS3 as a Novel Susceptibility Locus for Panic Disorder in the FinnGen Study

Panic disorder is an anxiety disorder with poorly understood etiology. Although twin studies suggest modest heritability (∼40%), few genetic variants have been associated with it. We carried out a gen...

medrxiv.org

#ctglab is hiring! We have #vacancies! 2 PhD & 2 postdoc positions, in #statistical #genetics and/or #bioinformatics - if you like GWAS, method development and linking with biology - check these out 👇 werkenbij.vu.nl/vacatures/tw... werkenbij.vu.nl/vacatures/po... werkenbij.vu.nl/vacatures/po...

Great to see this paper finally online, and happy we could contribute (a bit) to it! It's a big progress in regard to variant discovery (especially for the other 4 Big 5) but Ted and team also ran a wide range of super interesting follow-up analyses, that showcase the potential of the results. 🥳🧬

Ted Schwaba@tedmond.bsky.social · last yr.

Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...

We are currently looking for new collaborators with genotyping and autism data in order to increase our sample size for our next large-scale genome-wide meta-analyses of autism. Want to contribute? Contact us! 📩 pgc.unc.edu/for-research...