Feeling incredibly grateful to join this amazing cohort of scientists! Thanks to all my mentors that have helped get me this far. www.bwfund.org/news/bwf-ann...

BWF Announces the 2026 Investigators in the Pathogenesis of Infectious Disease - Burroughs Wellcome Fund

DURHAM, N.C. – The Burroughs Wellcome Fund is pleased to announce the recipients of the 2026 Investigators in the Pathogenesis of Infectious Disease (PATH) awards, recognizing assistant professor-leve...

bwfund.org

Please check out our latest publication where we find that caspase-3, which mediates what is thought to be an immunologically silent form of cell death is important for protecting against bacterial infections. Congrats to the whole team for making this possible. journals.plos.org/plospathogen...

Human non-canonical inflammasomes activate CASP3 to limit intracellular Salmonella replication in macrophages

Author summary The immune system uses specialized sensors called inflammasomes to detect infection and trigger protective responses. These responses are carried out by enzymes known as caspases, which...

journals.plos.org

"Talent is universal, access must be designed, and excellence must be intentional!" Inspiration talk by Donita Brady at #ASBMB2026. Donita has worked tirelessly to bring access to Penn and beyond. Congrats on winning the Ruth Kirschtein Award!

Our Cell Death in Immunity and Inflammation session was phenomenal today at #ASBMB2026. A pleasure to co-organize this with Cornelius Taabazuing @taabaman.bsky.social. @ragoninstitute.bsky.social @upenn.edu Jianbin Ruan, @katbarnett.bsky.social, Kasia Groburz, & @pedrosvdr.bsky.social

STEM Black History Fact 27/28 Dr. William Montague Cobb was a founder of modern physical anthropology and used anatomy to counter scientific racism. www.pbs.org/education/bl...

Ten Black Scientists That Science Teachers Should Know About

Help your students see the possibilities of careers in STEM fields by providing them with diverse role models.

pbs.org

Please join us for the Cold Spring Harbor Asia @cshlnews.bsky.social meeting on Bacterial Infection & Host Defense this May 11-15 in Suzhou, China! We have a fantastic lineup of speakers. Abstract deadline is March 6. Hope to see you there!

Congratulations to Kahlilia Morris-Blanco (@pennepigenetics.bsky.social), @taabaman.bsky.social (BioBio) & @ralphwhiteiii.bsky.social (@penncbio.bsky.social) on being featured in @wiley.com's Index of Inspiring Black Scientists! tinyurl.com/2s4bkyfs

If you've ever wondered if there's anybody who could be a potential mentor to you, now there is an index to help you find mentors with similar interests. www.wiley.com/research/ind...

Index of Inspiring Black Scientists | Wiley

The Inspiring Black Scientists Index is a curated database celebrating diverse contributions to science. Join us in promoting education and collaboration.

wiley.com

Check out our latest work led by two talented postdocs, Madhura @mkulkarni.bsky.social and Chris. We find that CASP4/5 can cleave and activate CASP3/7, acting as initiators of both pyroptosis and apoptosis. Notably, both are needed for full pathogen defense! www.biorxiv.org/content/10.1...

Human non-canonical inflammasomes activate CASP3 to limit intracellular Salmonella replication in macrophages.

Inflammasomes are multiprotein signaling platforms that activate inflammatory caspases to induce pyroptosis. In humans, canonical inflammasomes activate CASP1, which cleaves the pore-forming protein g...

biorxiv.org

I just subscribed to Making Sense of It All! buttondown.com/liminalcreat...

Making Sense of It All

Hi! I’m Liz Neeley and I’m glad you’re here. Making Sense of It All is an outlet for my work at Liminal, which focuses on sensemaking in a noisy and complicated world. I built Liminal as an antidote t...

buttondown.com

Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...

Intracellular protein editing enables incorporation of noncanonical residues in endogenous proteins

The ability to study proteins in their native cellular context is crucial to our understanding of biology. In this work, we report a technology for intracellular protein editing, drawing from split in...

science.org

George Burslem@gburslem.bsky.social · 2y ago

Ever wanted to edit a protein sequence inside a living mammalian cell? Maybe to site specifically incorporate a non-canonical residue? Perhaps you’d like to do a pull down without an antibody? Or use a small molecule fluorophore to image an endogenous protein? 1/4

Two new preprints online today! One with @dremilygoldberg.bsky.social on lysine lactylation www.biorxiv.org/content/10.1... Another with @taabaman.bsky.social on new peptide tools to study caspases www.biorxiv.org/content/10.1...

Class I histone deacetylases catalyze lysine lactylation

Metabolism and post-translational modifications (PTMs) are intrinsically linked and the number of identified metabolites that can covalently modify proteins continues to increase. This metabolism/PTM ...

biorxiv.org

If you're preparing for graduate school interviews, here's a resource to help you prepare. journals.physiology.org/doi/full/10....

A practical guide to graduate school interviewing for historically excluded individuals | American Journal of Physiology-Heart and Circulatory Physiology

journals.physiology.org

Manuscript submitted! Kudos to the smart, hardworking trainees that made this gift possible for the holidays! I truly appreciate you all. 🎉🥂🥳

It was great to finally met Dr. @taabaman.bsky.social in person. Your science and commitment to education will continue making an impact. #CellBio2024

Please help us welcome the newest postdoc to join the Taabazuing lab. We are all immigrants in the lab, but Ashutosh is our first international student hailing from India.

Feeling recharged after our department retreat in the Poconos last weekend. Huge congrats to our postdoc Madhura for winning the poster prize! We also welcomed the latest postdoc to join the lab, Ashutosh.

Check out our lab's latest paper describing a mutually inhibitory complex between DPP9 and KEAP1 www.jbc.org/article/S002...

The Serine Protease DPP9 and the Redox Sensor KEAP1 Form a Mutually Inhibitory Complex

Synthetic inhibitors of the serine protease DPP9 activate the related NLRP1 and CARD8 inflammasomes and stimulate powerful innate immune responses. Thus, it seems plausible that a biomolecule similarl...

jbc.org

I'm SO thankful for my amazing lab! Out of over 350 global entries, my lab manager is in the finals for lab manager of the year award 2024. Help me show my appreciation by voting for Bohdana Discher for this year's award. Vote daily until December 1st. Thanks! www.ptglab.com/news/company...

Best Lab Manager Award

Proteintech is offering a $1000 award for the most outstanding lab manager.

ptglab.com

All letters of recommendations have been submitted so the only thing left to do now is write our next paper. Hoping to give the lab a submission gift for Christmas.

OK, #immunology Bluesky LFG! If, like me, you're trying to reconstruct the vibrant scientific network we had at the other place, these starter packs are a great start: go.bsky.app/2bqX3T7 go.bsky.app/PY5tCas go.bsky.app/FmERUoD go.bsky.app/AjNpW2h go.bsky.app/SinqoJU go.bsky.app/DmphBCT

Hi all! My name is Cornelius, and I'm an assistant professor in the Department of Biochemistry and Biophysics @pennmedicine.bsky.social @upenn.bsky.social. My lab is interested in host-pathogen interactions with a focus on how the host responds to infections. I'm passionate about mentoring, too!

go.bsky.app/2bqX3T7 - please send me your @bsky.app handles to include in this growing community.