Following our recent @natcomms.nature.com paper, we've now shared the story behind the study in a @springernature.com Behind the Paper post: how an initially puzzling observation led us to a broader view of bacterial metabolism during infection 🦠 communities.springernature.com/posts/when-a...

When a metabolite becomes more than a metabolite

communities.springernature.com

Pablo Laborda@pablolaborda.bsky.social · 3mo ago

Our latest work is out in @natcomms.nature.com! Clinical adaptation of #PseudomonasAeruginosa can drive pyruvate secretion, where it scavenges ROS, dampens immune activation and promotes persistence, highlighting bacterial metabolism as an active player in infection🦠 www.nature.com/articles/s41...

Our latest work is out in @natcomms.nature.com! Clinical adaptation of #PseudomonasAeruginosa can drive pyruvate secretion, where it scavenges ROS, dampens immune activation and promotes persistence, highlighting bacterial metabolism as an active player in infection🦠 www.nature.com/articles/s41...

Following up on our recent @natcomms.nature.com paper, we have now shared the story behind the study in a @springernature.com Behind the Paper post 🦠 With an amazing illustration by Elena Contel Maza (@helen.mushu.science in instagram) 🎨 communities.springernature.com/posts/when-a...

When antibiotic resistance mutations do more than resist antibiotics

communities.springernature.com

Pablo Laborda@pablolaborda.bsky.social · 4mo ago

The final version of our latest paper is now published in @natcomms.nature.com! This study illustrates how #AntibioticResistance mechanisms can reshape bacterial physiology beyond resistance itself, ultimately influencing infection dynamics in clinically relevant ways🦠 www.nature.com/articles/s41...

The final version of our latest paper is now published in @natcomms.nature.com! This study illustrates how #AntibioticResistance mechanisms can reshape bacterial physiology beyond resistance itself, ultimately influencing infection dynamics in clinically relevant ways🦠 www.nature.com/articles/s41...

Pablo Laborda@pablolaborda.bsky.social · 12mo ago

New preprint out! 📣🚨 We found that loss-of-function mutations in the carbapenem entry porin OprD of Pseudomonas aeruginosa do more than confer #AntibioticResistance: they reshape the bacterial membrane and interaction with the host, enhancing epithelial colonization capacity 🦠 #Microsky

Unnecessary bureaucracy is a global crisis impeding productivity, advancement of human and planetary wellbeing, science and sustainability. This self-inflicted problem urgently needs solution through global efforts at all levels. doi.org/10.1111/1751...

The best results come from diverse minds working together. I´m very happy to share a collaborative work between 3 biologists, 2 mathematicians, a physicist, a chemist, and a physician: www.biorxiv.org/cgi/content/... @the100footpole.bsky.social @omeuxeito.bsky.social @pablolaborda.bsky.social

Our latest comment is now out! We discuss how the infection environment can shape #AntimicrobialResistance phenotypes, an important but often overlooked factor for predicting antimicrobial efficacy against bacterial pathogens 🦠🧫 #MicroSky @rug-lrs.bsky.social

Trends in Microbiology@cp-trendsmicrobiol.bsky.social · 6mo ago

Rethinking antimicrobial resistance diagnostics: beyond standardized susceptibility testing

How does treatment induced antibiotic resistance happen in real-world infections? We analysed 25k Pseudomonas isolates from 180 patients in a clinical trial to find out! TLDR: The ecological and evolutionary paths are surprisingly diverse & complex even in patients receiving identical treatment…

Matthew J Shepherd@matthewjshepherd.bsky.social · 8mo ago

🚨 New pre-print! 🚨 In the largest study of its kind to-date, we investigate the ecological and evolutionary mechanisms driving within-patient evolution of antimicrobial resistance (AMR). Read here: www.biorxiv.org/content/10.6... , and follow along with this thread, discussing our findings (1/21)

🧵 New preprint! Our 4-lab team evolved Streptococcus pneumoniae in antibiotic-treated mice of varying immune states and discovered something surprising: bacteria rarely evolved resistance. Instead, they found a different way to survive — by rewiring RNA turnover. 🔗 www.biorxiv.org/content/10.6...

New paper out in PNAS!!! 🎉 Do more plasmid copies mean faster evolution? 🧵 Dive into the story www.pnas.org/doi/10.1073/...

Plasmid mutation rates scale with copy number | PNAS

Plasmids are extrachromosomal DNA molecules that spread by horizontal transfer and shape bacterial evolution. Plasmids are typically present at mul...

pnas.org

New preprint!👇 Pyruvate secreted by P. aeruginosa acts as a signaling molecule during infection, reducing oxidative stress, dampening immune activation and promoting persistence Bacterial metabolism isn’t just a background process but an active player in infection🦠🧫 www.biorxiv.org/content/10.6...

Immune protection and disease tolerance in Pseudomonas aeruginosa infections by pyruvate cross-feeding

Chronic infections by Pseudomonas aeruginosa in people with cystic fibrosis are characterized by persistent inflammation and oxidative stress, yet the mechanisms enabling bacterial persistence are not...

biorxiv.org

The @imili-micro.bsky.social project is such a beautiful and necessary initiative! I am really glad we could contribute. Special kudos to PhD student Lilibeth Torres who did the #Klebsiella drawing and wrote the text - @cbitoulouse.bsky.social

International Microbiology Literacy Initiative - IMiLI@imili-micro.bsky.social · 11mo ago

Everything you need to explain AMR to family and friends-12: @pablolaborda.bsky.social @crisherencias.bsky.social @pharmageddon.bsky.social @ecdc.europa.eu @eberllab.bsky.social @klebclub.bsky.social ‪ @olayarendueles.bsky.social‬ the ESKAPE Rogues www.imili-eah.com/prod-api/pro...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-10: @pablolaborda.bsky.social @crisherencias.bsky.social @pharmageddon.bsky.social @ecdc.europa.eu @eberllab.bsky.social the ESKAPE Rogues grupos.eez.csic.es/imili/wp-con...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-11: @pablolaborda.bsky.social @crisherencias.bsky.social @pharmageddon.bsky.social @ecdc.europa.eu @eberllab.bsky.social the ESKAPE Rogues grupos.eez.csic.es/imili/wp-con...

The NoticiaSEM: an excellent monthly newsletter for Spanish-speaking microbiologists, now celebrating its 200th edition. It also publishes Portraits from the IMiLI. On the occasion of its 200th "birthday", it published an IMiLI "MicroChat" on......birthdays. www.semicrobiologia.org/revista-noti...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-5 @pablolaborda.bsky.social How we can fight AMR imili.org/new_gallerie... @sbigot.bsky.social

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-6 @pablolaborda.bsky.social, @crisherencias.bsky.social How we can fight AMR imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-7 @pablolaborda.bsky.social @crisherencias.bsky.social How we can fight AMR imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-8 @pablolaborda.bsky.social @crisherencias.bsky.social How it works imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-9 @pablolaborda.bsky.social @crisherencias.bsky.social How it works imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-4 @pablolaborda.bsky.social imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-3 @pablolaborda.bsky.social imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-2 @pablolaborda.bsky.social imili.org/pdf/Antimicr...

Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-1 @pablolaborda.bsky.social imili.org/pdf/Antimicr...

New preprint out! 📣🚨 We found that loss-of-function mutations in the carbapenem entry porin OprD of Pseudomonas aeruginosa do more than confer #AntibioticResistance: they reshape the bacterial membrane and interaction with the host, enhancing epithelial colonization capacity 🦠 #Microsky

bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 12mo ago

Carbapenem-resistance oprD mutations reshape Pseudomonas aeruginosa host-pathogen interactions during infection https://www.biorxiv.org/content/10.1101/2025.10.24.684370v1

We just opened the Bluesky account of the International Microbiology Literacy Initiative (IMiLI) headed by Ken Timmis. Follow us to know more about the initiative or even better become one of our volunteers to bring Microbiology to kids all ages around the world 🦠 🏫

International Microbiology Literacy Initiative - IMiLI@imili-micro.bsky.social · last yr.

Welcome to the social media account of the International Microbiology Literacy Initiative (IMiLI). Nearly 1,000 researchers freely contribute to the IMiLI project integrating microbiology into education providing downloadable resources for all. Explore at imili.org

Welcome to the social media account of the International Microbiology Literacy Initiative (IMiLI). Nearly 1,000 researchers freely contribute to the IMiLI project integrating microbiology into education providing downloadable resources for all. Explore at imili.org

This work is finally published! 🥳🧬 Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by @jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14

Dissecting pOXA-48 fitness effects in clinical Enterobacterales using plasmid-wide CRISPRi screens

Nature Communications - This study investigates the effects of the carbapenem resistance plasmid pOXA-48 in clinical enterobacteria. Using CRISPRi screens, the authors revealed that the...

rdcu.be

New paper out! 🔈🔈📣📣 Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation. Combining experimental and computational approaches, we unveil how two of the most prevalent bacterial MGE accelerate the evolution of AMR. 🧵👇🏻 www.biorxiv.org/content/10.1...

Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation

Antimicrobial Resistance (AMR) is a major threat to public health. Plasmids are mobile genetic elements that can rapidly spread across bacterial populations, promoting the dissemination of AMR genes i...

biorxiv.org

Do plasmids evolve faster 🐇, slower 🐢, or just like chromosomes 🧬? In our new paper, we tackled this question using theory, simulations, bioinformatics, and experiments! 👇 Check out all the details in Paula’s thread! Hint: 🐇 (most of the time)

Plasmids promote bacterial evolution through a copy number-driven increase in mutation rate

Plasmids are autonomously replicating DNA molecules that stably coexist with chromosomes in bacterial cells. These genetic elements drive horizontal gene transfer and play a fundamental role in bacter...

biorxiv.org

Paula Ramiro-Martínez@paularamiro.bsky.social · last yr.

New paper alert! 🚨 Plasmids promote bacterial evolution through a copy number-driven increase in mutation rate. We combine theory, simulations, experimental evolution, and bioinformatics to demonstrate that mutation rates scale with plasmid copy number. Let's dive in! 🧵👇