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Sara Hernando-Amado

@hernando-amado.bsky.social

Ecology and evolution of antibiotic resistance at CNB-CSIC. @besaraornottobe on X 🐤

108 Posts316 Follower276 Folgt
Pablo Laborda@pablolaborda.bsky.social · 4w ago

Our latest work is out in @natcomms.nature.com! Clinical adaptation of #PseudomonasAeruginosa can drive pyruvate secretion, where it scavenges ROS, dampens immune activation and promotes persistence, highlighting bacterial metabolism as an active player in infection🦠 www.nature.com/articles/s41...

Immune protection and persistence in Pseudomonas aeruginosa infections by pyruvate cross-feeding - Nature Communications

The study shows that metabolic mutations in Pseudomonas aeruginosa lead to pyruvate secretion, which reduces oxidative stress, dampens immune responses, promoting bacterial survival and persistence in...

nature.com

Centro Nacional de Biotecnología (CNB)@cnb-csic.bsky.social · 2mo ago

Compartimos con gran tristeza el fallecimiento de Ana Clara Carrera, investigadora del CNB durante más de 30 años. Ana Clara ha sido un referente tanto profesional como personal por su inteligencia, empuje y  alegría. Nuestras condolencias a su familia y seres queridos. Descansa en paz, querida Ana💔

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Alejandro Tejada Arranz@atejadaarranz.bsky.social · 2mo ago

Our paper on a microbiology practical course for bachelor students focusing on T6SS dynamics, microbiology and fluorescence microscopy techniques is out @microbiologysociety.org, check it out! @basler-lab.bsky.social 👇 www.microbiologyresearch.org/content/jour...

Type VI secretion system-mediated bacterial antagonism in the classroom

The study of bacterial antagonism, and specifically type VI secretion system (T6SS)-mediated antagonism, has gained momentum over the last decade in research laboratories across the world. The T6SS is...

microbiologyresearch.org

Pablo Laborda@pablolaborda.bsky.social · 2mo ago

Following up on our recent @natcomms.nature.com paper, we have now shared the story behind the study in a @springernature.com Behind the Paper post 🦠 With an amazing illustration by Elena Contel Maza (@helen.mushu.science in instagram) 🎨 communities.springernature.com/posts/when-a...

When antibiotic resistance mutations do more than resist antibiotics

communities.springernature.com

Pablo Laborda@pablolaborda.bsky.social · 2mo ago

The final version of our latest paper is now published in @natcomms.nature.com! This study illustrates how #AntibioticResistance mechanisms can reshape bacterial physiology beyond resistance itself, ultimately influencing infection dynamics in clinically relevant ways🦠 www.nature.com/articles/s41...

Pablo Laborda@pablolaborda.bsky.social · 2mo ago

The final version of our latest paper is now published in @natcomms.nature.com! This study illustrates how #AntibioticResistance mechanisms can reshape bacterial physiology beyond resistance itself, ultimately influencing infection dynamics in clinically relevant ways🦠 www.nature.com/articles/s41...

Carbapenem-resistance oprD mutations reshape Pseudomonas aeruginosa host-pathogen interactions during infection - Nature Communications

In this work, authors show that the loss of the carbapenem porin OprD in Pseudomonas aeruginosa reduces mucus entrapment and enhances airway epithelial barrier crossing, illustrating how antibiotic re...

nature.com

Pablo Laborda@pablolaborda.bsky.social · 9mo ago

New preprint out! 📣🚨 We found that loss-of-function mutations in the carbapenem entry porin OprD of Pseudomonas aeruginosa do more than confer #AntibioticResistance: they reshape the bacterial membrane and interaction with the host, enhancing epithelial colonization capacity 🦠 #Microsky

Saúl Ares@omeuxeito.bsky.social · 3mo ago

Now proudly published in PRE! @physreve.bsky.social journals.aps.org/pre/abstract... If you don't have access to the published version, don't worry, we've got you covered: the arXiv has been updated to match the published version.

Optimization of sequential therapies to maximize extinction of resistant bacteria through collateral sensitivity

Antimicrobial resistance (AMR) threatens global health. A promising and underexplored strategy to tackle this problem is sequential therapies exploiting collateral sensitivity (CS), whereby resistance...

journals.aps.org

Saúl Ares@omeuxeito.bsky.social · 10mo ago

New preprint v2: stochastic modeling of sequential antibiotic therapy. We identify an intermediate switching period that maximizes extinction and quantify the clearance ↔ double-resistance Pareto trade-off. Feedback welcome! arxiv.org/abs/2510.01808 #AMR #evolution #antibiotics #stochastic

Schulenburg Lab Kiel@schulenburglab.bsky.social · 4mo ago

Just out: our new study on hysteresis and antibiotic resistance! Great work by Florian Buchholz, Lina Upterworth, Roderich Roemhild and others, incl @bramkamplab.bsky.social @holgersondermann.bsky.social www.nature.com/articles/s41...

Robust antibiotic sensitization of pathogenic Pseudomonas aeruginosa via negative hysteresis in the cell envelope - Nature Communications

Here, the authors describe negative hysteresis as a phenomenon where the initial exposure of Pseudomonas aeruginosa to β-lactam antibiotics causes cellular sensitization towards aminoglycoside antibio...

nature.com

Teresa M. Coque@tmcoque.bsky.social · 4mo ago

In summary, Why matters?: • No microbiome is truly “pristine” • Environmental factors (like Hg pollution) are relevant selective pressures • Resistance can spread fast even in low-impact communities • Definition of "backbone" and "baseline" resistomes are key to interpret AMR

Teresa M. Coque@tmcoque.bsky.social · 4mo ago

We are pleased to share our last article rdcu.be/fabhM. It offers the most comprehensive analysis so far of Ab+non-Ab resistance genes in human gut microbiome, using an Indigenous population (low industrialization, chronic Hg exposure from gold mining) 6/6👇

The antimicrobial gut resistome of the Wayampi reveals a shared background of antibiotic and metal resistance genes with industrialized populations, underscoring the “robust-yet-fragile” architecture ...

rdcu.be

Lluis Montoliu@lluismontoliu.bsky.social · 5mo ago

Hoy es el #DíaMundialDeLasEnfermedadesRaras, siempre el último día de febrero, el menos frecuente de todos, el más “raro”, que llega a 29 en los años bisiestos y se queda en 28 en los tres años intermedios. Os invito a leer este artículo en @es.theconversation.com theconversation.com/las-enfermed...

Las enfermedades raras no son tan raras

Una de las mayores paradojas de las enfermedades raras es que no son tan raras. Globalmente afectan a millones de personas, a pesar de que cada una afecta a pocos pacientes.

theconversation.com

Antimicrobianos Hub CSIC@amrhubcsic.bsky.social · 5mo ago

📝Dentro del Plan Nacional frente a la Resistencia a Antibióticos está el proyecto ESUAvet, un proyecto voluntario que está ayudando al registro y control de los medicamentos en la comunidad veterinaria. ¿Cómo funciona? 👇

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Antimicrobianos Hub CSIC@amrhubcsic.bsky.social · 5mo ago

💊 'Cuanto más, mejor' vale para muchas cosas, pero no para el uso de antibióticos. Por eso los hospitales o sistemas de salud organizan los programas de optimización de uso de antibióticos (PROA), para determinar precisamente qué vale y qué no en el uso responsable de antibióticos. 👇

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