Glad we didn't do this paper in LC or that would've been career capstone'd. Jacqui's analyses examine these data more deeply and thoroughly than imaginable! www.biorxiv.org/content/10.6...

Overlapping yet distinct spatiomolecular profiles across mood disorders and biological sex in the human prefrontal cortex

Major depressive disorder (MDD) and bipolar disorder (BD) exhibit both overlapping and distinct clinical features, including sex differences in prevalence and symptomatology, but how these similaritie...

biorxiv.org

Impromptu field research lunch yesterday turned up a looooooooonnngggg kitten for adoption at Affogatto cat cafe

Have some (a boatload) more LC! www.nature.com/articles/s41...

Topographic structure and function of locus coeruleus noradrenaline neurons - Nature

Dorsal and ventral noradrenergic neurons in the locus coeruleus form topographic subpopulations whose projection patterns and activity encode choice switching, reward-prediction errors and disregard o...

nature.com

Excited to share work with cryostat wizard @heenadivecha.bsky.social looking at gene expression in my favorite brain region (LC) in adult postmortem brain! (Long URL to spare the trouble of identifying cars, buses, beds in 5x5 pixel imgs). (1/x) link.springer.com/epdf/10.1007...

Study the biology of sex hormones and sex differences, folks! (From this week's @bbrfoundation.bsky.social seminar by @clearlab.bsky.social )

For #FluorescenceFriday - maybe not the prettiest ever, but scientifically just super cool - zoom in to see DBH transcripts 🔵, marking noradrenergic neurons in locus coeruleus of human 🧠... w/ unexpected boatload of CARTPT 🔴. Image/data credits @berniejmulvey.bsky.social @heenadivecha.bsky.social

Excited to share our spatial omics from hypothal. are out in Cell Rep--with more interactive data browsing coming soon w/ UCSC single-cell browser! @kr-maynard.bsky.social @kasperdhansen.bsky.social •Paper: www.cell.com/cell-reports... •UCSC (demo): cells-test.gi.ucsc.edu?ds=hypothala...

Spatially resolved molecular sex differences at single-cell resolution in the adult human ventromedial and arcuate hypothalamus

The ventromedial hypothalamus (VMH) and arcuate (ARC) nuclei of the hypothalamus play critical roles in regulating metabolism and behavior. Here, Mulvey et al. create a focused spatial transcriptomic ...

cell.com

Proud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula doi.org/10.1176/appi...

Transcriptomic Analysis of the Human Habenula in Schizophrenia | American Journal of Psychiatry

Objective: The objective of this study was to define the molecular neuroanatomy of the human habenula (Hb) and identify transcriptomic differences between brains of individuals with schizophrenia and ...

doi.org

A large study of developing brains reveals genetic and molecular differences between males and females. The findings may help explain why neurodevelopmental conditions, including autism, occur at different rates in boys and girls. By @giorgiag-sciwriter.bsky.social bit.ly/4q9BsVH

Gene-activity map of developing brain reveals new clues about autism’s sex bias

Boys and girls may be vulnerable to different genetic changes, which could help explain why the condition is more common in boys despite linked variants appearing more often in girls.

bit.ly

10/8: Any time you see two tissue sections, the other was the preceding or subsequent 10µm of tissue cut from the same donor, because @heenadivecha.bsky.social is a beast! As is the link to the browser with all 85 tissue sections available: samuibrowser.com/from?url=dat...

Bernie Mulvey@berniejmulvey.bsky.social · last yr.

9/8: The high-res spatial expression browser! Full-resolution of H&E stained tissue sections and the gene expression from them. Great for seeing neuromelanin. (One sample = one tissue section).

9/8: The high-res spatial expression browser! Full-resolution of H&E stained tissue sections and the gene expression from them. Great for seeing neuromelanin. (One sample = one tissue section).

Bernie Mulvey@berniejmulvey.bsky.social · last yr.

Got with the times + made a BSky to share our new, large-scale spatial RNAseq study of adult human #locuscoeruleus! Co-1st auth and cryostat wizard @heenadivecha.bsky.social squeezed 85 tissue sections into 43 Visium arrays. (1/8) www.biorxiv.org/content/10.1...

Got with the times + made a BSky to share our new, large-scale spatial RNAseq study of adult human #locuscoeruleus! Co-1st auth and cryostat wizard @heenadivecha.bsky.social squeezed 85 tissue sections into 43 Visium arrays. (1/8) www.biorxiv.org/content/10.1...

Impact of Alzheimer's disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus

The locus coeruleus (LC) is a small noradrenergic nucleus in the dorsal pons that sends projections across the brain regulating sleep, arousal, attention, stress responses, and some forms of cognition...

biorxiv.org