Excited to share our latest preprint from @lieberinstitute.bsky.social spatial + single-cell RNA-seq map the ERC & explore how AD risk shapes gene expression doi.org/10.1101/2025... Our major finding: “APOE E4 Alzheimer’s Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex”

Proud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula doi.org/10.1176/appi...

Transcriptomic Analysis of the Human Habenula in Schizophrenia | American Journal of Psychiatry

Objective: The objective of this study was to define the molecular neuroanatomy of the human habenula (Hb) and identify transcriptomic differences between brains of individuals with schizophrenia and ...

doi.org

Learning more about APOE differences in the cell types of the brain 🧠 I presented "APOE genotype determines cell-type-specific pathological landscape of Alzheimer’s disease" from @zhaonaa.bsky.social at our team journal club, check it out! doi.org/10.1016/j.ne... ▶️ youtu.be/L4J9jFS-Pic

Hi! Check my journal club talk: smart ML method to deconvolute pooled snRNA-seq using sex-specific expression🧬 Thanks @daylab.bsky.social & @rphillips3.bsky.social for this approach🙌 🎥 youtu.be/zpeCFwYfV3o 🛝 speakerdeck.com/manishabarse #snRNAseq #ML #Bioinformatics @lieberinstitute.bsky.social

[2025-04-23] Journal club on "[...] deconvolution of pooled snRNA-seq using sex-dependent gene expr"

YouTube video by Leonardo Collado Torres

youtu.be

Hey #deconvolution fans! 👀 We’ve got an exciting new publication for you: a benchmark of 6 popular deconvolution methods on a multimodal human brain #DLPFC dataset 🧠🧬 Now out in Genome Biology: doi.org/10.1186/s130... @lieberinstitute.bsky.social @jhubiostat.bsky.social

Benchmark of cellular deconvolution methods using a multi-assay dataset from postmortem human prefrontal cortex - Genome Biology

Cellular deconvolution of bulk RNA-sequencing data using single cell/nuclei RNA-seq reference data is an important strategy for estimating cell type composition in heterogeneous tissues, such as the h...

doi.org

Check out my journal club presentation on the crumblr pre-print from Hoffman and Roussos, a new method to analyze differential composition in #singlecell data 🍪 Looks very useful for single cell RNA-seq data with case/control study design 🤔 📄 doi.org/10.1101/2025... ▶️ www.youtube.com/watch?v=Hi5E...

Fast, flexible analysis of differences in cellular composition with crumblr

Changes in cell type composition play an important role in human health and disease. Recent advances in single-cell technology have enabled the measurement of cell type composition at increasing cell ...

doi.org

Check our recent video "[2025-01-29] R/Bioconductor-powered Team Data Science: TLDR version 2025" youtu.be/alL-g2roXxM We go over what analyses our @lieberinstitute.bsky.social has expertise on 💻 Slides orchestrated by @lahuuki.bsky.social at speakerdeck.com/lahuuki/2025... 👥 go.bsky.app/53gy4UP

Reading the instructions first next time 😅 completed "Ceres Search" - Day 4 - Advent of Code 2024 #AdventOfCode adventofcode.com/2024/day/4

I've completed "Red-Nosed Reports" - Day 2 - Advent of Code 2024 🔴 #AdventOfCode adventofcode.com/2024/day/2

I decided to make a starter pack for members/alumni of @lieberinstitute.bsky.social "Data Science Team 1" 💻 Initially led by @aejaffe.bsky.social until 2020/09; then by me. In 2024, the team became part of the Division of Translational Neuroscience led by @martinowk.bsky.social go.bsky.app/53gy4UP

Hi Bluesky! 👋 I'm Louise Huuki-Myers I work on transciptomic research in the brain 🧠🧬 @lieberinstitute.bsky.social and am Studying for my PhD in #neuroscience at the University of Cambridge. Excited to share more about neurosci research and #Rstats here 🦋