The abstract submission deadline for #EESRNA is only a week away! Don't miss your chance to present your research at the EMBO | EMBL Symposium 'The complex life of RNA', the central event for the RNA community. Submit your abstract by 7 July: s.embl.org/ees26-12-bl #RNA #RNAbiology

Abstract submission deadline is approaching for "The complex life of RNA" @embl.org in Heidelberg 13-16. October 2026! There will be almost 30 selected talks! Submission deadline: 7. July 2026!

EMBL Events@events.embl.org · 2mo ago

Join us for the next edition of the EMBO | EMBL Symposium 'The complex life of RNA'! 🔬🧬 The programme will include topics on transcription, RNA processing and modification, mRNA export and localisation, mRNA surveillance and decay, and more 💻 s.embl.org/ees26-12-bl

Paraspeckle condensation is controlled via TDP-43 polymerization and linked to neuroprotection! www.nature.com/articles/s41... Excellent work from Tatyana Shelkovnikova Lab in @natcellbio.nature.com in collaboration @embl.org

Using #SingleMolecule imaging we find that TFs: -boost co-transcriptional #ribosomal #RNA processing! -their binding #dynamics fundamentally differ for mRNA (transient) versus rRNA #transcription (stable)! @biorxivpreprint.bsky.social Anastasiia Chaban @embl.org www.biorxiv.org/content/10.6...

My first PhD student‘s, Kavan Gor, paper on 5-color single-molecule imaging of co-transcriptional RNA folding is out in @science.org Advances! He finds how RNA modification enzymes, antisense oligonucleotides and ribosomal proteins re-route nascent RNA folding. See more details in EMBL post below!

EMBL@embl.org · 4mo ago

(1/2) EMBL researchers led by @olivierduss.bsky.social have developed a microscopy technique that enables them to observe individual RNA molecules being produced and folding into different shapes. Learn more: www.science.org/doi/10.1126/...

Anthony A. Hyman will become EMBL’s next Director General. He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999. www.embl.org/news/people-...

Registration is open for "The complex life of #RNA" 2026 @embl.org in Heidelberg! Excellent invited speakers and 30 short talks and even more flash talks selected from the abstracts!

EMBL Events@events.embl.org · 9mo ago

Come discuss recent breakthroughs in RNA biology, from molecules to organisms, at the EMBO | EMBL Symposium 'The complex life of RNA'! 👉 s.embl.org/ees26-12-bl Submit your abstract by 7 July and present your research at #EESRNA 🥼

The story of how multiple RBPs cooperate to repress translation is now out in @cp-cellreports.bsky.social by @marcopayr.bsky.social and in a great collaboration with @hennig-lab.bsky.social! www.cell.com/cell-reports...

Olivier Duss@olivierduss.bsky.social · last yr.

Ever wondered how several individual RBPs cooperate to repress translation? Lead by @marcopayr.bsky.social and in great collaboration with @hennig-lab.bsky.social, we simultaneously tracked the binding of several proteins to single mRNA molecules in real-time! www.biorxiv.org/content/10.1...

Thinking Like a Scientist, Part Two: The Omics Illusion network.febs.org/posts/thinki... #FEBSnet

Thinking like a Scientist: The Limits of Genome Editing and Omics

Second part of Thinking like a Scientist, reflecting on how genome editing and multi-omics, while powerful, can introduce conceptual flaws that distort our understanding of gene function and biologica...

network.febs.org

Excited to share my first PhD student’s @biorxivpreprint.bsky.social! Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules! Check it out! www.biorxiv.org/content/10.1...

Travel’s got me wiped, but catching up with @colindascheele.bsky.social, @pierresantucci.bsky.social & @olivierduss.bsky.social at #FEBS2025 made it totally worth it. Huge thanks to Pelin Telkoparan and Dilek Cevik for the wonderful hospitality—what a time in Istanbul!

Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals. www.science.org/doi/10.1126/...

Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis

Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...

science.org

The timeline of co-transcriptional #mRNA processing and #modification may have to be revised: cleavage, termination, and #m6A deposition may occur earlier than most #splicing! Potential textbook changing study in bioRxiv by edueyras.bsky.social & Rippei Hayashi labs! www.biorxiv.org/content/10.1...

Single-molecule multimodal timing of in vivo mRNA synthesis

mRNA synthesis requires extensive pre-mRNA maturation, the organisation of which remains unclear. Here, we directly sequence pre-mRNA without metabolic labelling or amplification to resolve transcript...

biorxiv.org

Five people have seen a color never before visible to the naked human eye, thanks to a new retinal stimulation technique called Oz. Learn more in #ScienceAdvances: scim.ag/442Hjn6

Novel color via stimulation of individual photoreceptors at population scale

Image display by cell-by-cell retina stimulation, enabling colors impossible to see under natural viewing.

scim.ag

Check out our preprint at BioRxiv revealing mechanisms of mRNP assembly during translation repression: (www.biorxiv.org/content/10.1...). Great collaboration with Olivier Duss (@olivierduss.bsky.social). Great Work Marco Payr (@marcopayr.bsky.social) and thanks for the video, explaining our paper.

Ever wondered how several individual RBPs cooperate to repress translation? Lead by @marcopayr.bsky.social and in great collaboration with @hennig-lab.bsky.social, we simultaneously tracked the binding of several proteins to single mRNA molecules in real-time! www.biorxiv.org/content/10.1...

Marco Payr@marcopayr.bsky.social · last yr.

In a collaboration between the @hennig-lab.bsky.social and @olivierduss.bsky.social labs we revealed how proteins work together to control gene expression through mRNA translation repression! Using single-molecule microscopy, we watched individual molecules in action. doi.org/10.1101/2025... 🧵

Great work led by our PhD student Iuliia Kotova in collaboration with Fan Liu @fan-liu.bsky.social, Boris Bogdanow, Lars Mühlberg, and Olivier Duss @olivierduss.bsky.social and Guelsah Gabriel labs. Structural analysis by our PhD student Konstantin Gilep. www.biorxiv.org/content/10.1...

Snapshot of in-cell protein contact sites reveals new host factors and hijacking of paraspeckles during influenza A virus infection

Influenza A virus (IAV) exploits the host cellular machinery to facilitate its replication, yet many host-IAV interactions remain unexplored in the cellular context. Detailed information about interac...

biorxiv.org

www.science.org/doi/10.1126/... Tour de force by Barna Lab

A subcellular map of translational machinery composition and regulation at the single-molecule level

Millions of ribosomes are packed within mammalian cells, yet we lack tools to visualize them in toto and characterize their subcellular composition. In this study, we present ribosome expansion micros...

science.org

The RNA helicase HrpA rescues collided ribosomes in E. coli

The RNA helicase HrpA rescues collided ribosomes in E. coli

Antibiotics that inhibit ribosomes lead to collisions on mRNAs when upstream ribosomes catch up with stalled ones. Campbell et al. show that the HrpA protein in E. coli senses ribosome collisions and removes the stalled ribosome, helping cells survive in…

dlvr.it

In a remarkable new paper, Qureshi and Duss use multi-colour single-molecule fluorescence microscopy to directly and simultaneously track transcription, translation & coupling 3/n www.nature.com/articles/s41...

Just published: My (Janosch Hennig) view on the current capabilities of AF3 and similar for RNA and protein-RNA complex structure prediction plus a bit of forward looking: doi.org/10.1002/cbic...

Structural biology of RNA and protein‐RNA complexes after AlphaFold3

Recent breakthroughs in AI-mediated protein structure prediction have significantly accelerated research and generated valuable hypotheses within the field of structural biology and beyond. Notably, ...

doi.org

Check it out! Another novel RNA modification - ADP-ribosylation - that was previously only known on proteins. A cousin to #glycoRNA 👏 www.nature.com/articles/s41...

#cryoET of Mycoplasma pneumoniae Chloramphenicol-bound ribosomes at a global 3.0 Å resolution www.nature.com/articles/s41...

Excited to share our new work on the earliest steps of Pol-III transcription: We provide structural and kinetic insights into tRNA promoter engagement by yeast transcription factor TFIIIC ! Cool collaboration with the Müller and Eustermann Labs @embl.org ! academic.oup.com/nar/advance-...

Structural and kinetic insights into tRNA promoter engagement by yeast general transcription factor TFIIIC

Abstract. Transcription of transfer RNA (tRNA) genes by RNA polymerase (Pol) III requires the general transcription factor IIIC (TFIIIC), which recognizes

academic.oup.com

EMBL Group Leader @olivierduss.bsky.social and his research team discovered how two molecular machines in bacteria work together and watched their interactions as a real-time movie. Discover how they put snapshots in motion 👉 www.embl.org/news/science... #MolBiol 🧪 @natureportfolio.bsky.social

First paper of our lab today @natureportfolio.bsky.social by Nussi! We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping! @embl.org #RNAbiology #RNASky t.co/a24Xxcxdo0

Congratulations, Olivier Duss, Simone Köhler, and Eva Kowalinski! 👏 The three EMBL Group Leaders have received ERC Consolidator Grants #ERCCoG for their innovative research projects aimed at understanding fundamental cellular mechanisms. #MolBiol 🧪👇 Read more here: www.embl.org/news/awards-...

Very grateful to get support from the #ERC Consolidator grant! -to study how #transcription, #translation and #DNA repair cooperate -combining #single-molecule #microscopy in vitro & live cells and #cryoET -obtaining a real-time movie 🎥 🎞️ -hiring soon @embl.org! www.embl.org/news/awards-...

Excited to share our study led by @SakenovaNazgul! We used chemical genetics to identify and understand cross-resistance & collateral-sensitivity (CS) between antibiotics and reduced AMR development with CS drug pairs @embl.org with @camille_goemans @EPFL_en www.nature.com/articles/s41...

Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics - Nature Microbiology

Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. This study presents an approach to systematically discover and ...

nature.com

Happy to share the website of RiboMod2025, the "Conference on Ribosomal RNA modifications and snoRNAs" in Bologna June 12-13, 2025 is up at events.unibo.it/ribomod2025 Stay tune for more infos! #RNA #Ribosome #snoRNA #Eiptranscriptomics