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Dave Leitch and the Leitch Lab
@leitchlab.bsky.social
Catalysis / physorg / HTE / organic synthesis research group at the University of Victoria.
𝐇𝐨𝐰 𝐜𝐚𝐧 𝐲𝐨𝐮 𝐛𝐞𝐬𝐭 𝐚𝐬𝐬𝐞𝐬𝐬 𝐭𝐡𝐞 𝐬𝐭𝐚𝐛𝐢𝐥𝐢𝐭𝐲 𝐨𝐟 𝐜𝐨𝐯𝐚𝐥𝐞𝐧𝐭 𝐢𝐧𝐡𝐢𝐛𝐢𝐭𝐨𝐫𝐬 𝐟𝐨𝐫 𝐟𝐮𝐫𝐭𝐡𝐞𝐫 𝐝𝐞𝐯𝐞𝐥𝐨𝐩𝐦𝐞𝐧𝐭? An interesting paper by the group of Jeffrey Keillor in the Journal of Medicinal Chemistry addresses this important question. (1/4) doi.org/10.1021/acs.... #ChemSky #ChemBio #DrugDiscovery #CovalentDrugs
Don’t Lose Your (War)head: Structure–Activity Relationships of Covalent Warheads as Substrates for GST-Catalyzed Glutathione Conjugation
Abstract. The resurgence of targeted covalent inhibitors (TCIs) has expanded the diversity of electrophilic warheads used in drug discovery. TCIs must bala
doi.org
Introduce yourself as what almost killed you. Hi, I'm Alta Chute III at Jackson Hole WY.
Chemjobber@chemjobber.bsky.social · 2w agoIntroduce yourself as what almost killed you. Hi, I'm being in your 20s, testosterone, stupidity and a Class III rapid
When I first saw the new ACS logo, my immediate thought was "this is for a 1980s era tech company" #chemsky You be the judge:
Chemistry World@chemistryworld.com · 4w agoA facility housing large tanks of methyl methacrylate, the monomer form of polymethyl methacrylate was overheating this May. @chemjobber.bsky.social explores the lessons learned & how risky runaway polymerisation can be prevented in the future: www.chemistryworld.com/opinion/earl...
There's just something surreal about bicyclobutanes. Read how Justin Lopchuk and colleagues figured out how to add these strained bisected bits to covalent drug candidates. My latest in @cenmag.bsky.social #chemsky🧪 cen.acs.org/pharmaceutic...
The covalent drug arsenal gets a new warhead
A mild, modular approach to adding bicyclobutanes could bring more selectivity to these therapies
cen.acs.org
Rewrite a book title to ruin it Fahrenheit 45
John Madden@mathletesfoot.bsky.social · last mo.Rewrite a book title to ruin it. Steakhouse-five
Not all of our professors were educated at UVic, but some of them were educated by UVic alumni. And those alumni have changed the course of their lives. Read about chemistry professor David Leitch and the alumni who shaped his path. https://ow.ly/6xoA50Zs9wq
Lessons in Chemistry - Alumni - University of Victoria
UVic researcher and associate professor David Leitch is inventing new chemistry to create drugs and medicines more efficiently and with less waste.
ow.ly
A24’s ‘Elden Ring’ Film Stalled After Red Phantom Named TwinkPunisher Invades Set https://theonion.com/a24s-elden-ring-film-stalled-after-red-phantom-named-twinkpunisher-invades-set/
Farewell and rest well to a phenomenal, inspiring, and prolific scientist. I will always remember a talk he gave at McGill that chronicled his scientific life story, ending with his advice on the secret to success: "You have to work very haaaard!" www.caltech.edu/about/news/c...
Caltech Mourns the Passing of Nobel Laureate Rudy Marcus (1923–2026)
Marcus passed away on July 16. He was 102.
caltech.edu
1/ 🌊 Hiring: Director of Science, @oceannetworks.ca Lead ONC's science division and help shape the future of ocean observing. A rare exec-level role for an ocean science leader 🔗 findajob.agu.org/job/8026757
Director, Science Services - Victoria, British Columbia job with Ocean Networks Canada, University of Victoria | 8026757
ONC is seeking a passionate and experienced leader and ocean science expert to drive the development and delivery of ONC’s Science division.
findajob.agu.org
Happy 80th birthday to a legend, a Mexican-American icon, and one of the greatest vocalists of all time, Miss Linda Ronstadt ✨
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