We wanted to share this asap for everyone to use ! This will remain a #preprint for the time being. We are happy to recieve feedback, hear whether or not ot works in your hands and continue to apply it across #eukaryotes as part of #ExÂME You want to know more : www.dudinlab.com/exame

Research

ExÂME is the Expansion Microscopy Atlas of Microbial Eukaryotes, a community-driven project uncovering the hidden cellular architectures of protists and microbial eukaryotes. Supported by the Moore Fo...

dudinlab.com

Millions of beating cilia keep airways clean. At the base of each is the transition zone (TZ), a gate that controls which proteins enter and leave. In our paper out today in Science, we used cryo-FIB-ET to image the TZ inside human airway cells www.science.org/doi/10.1126/...

In situ structure of the human ciliary transition zone links linker defects to primary ciliary dyskinesia

The ciliary transition zone (TZ) regulates ciliary proteome composition, yet its molecular architecture, protein content, and contribution to motile ciliopathies remain poorly defined. We applied in situ cryo-electron tomography and subtomogram averaging ...

science.org

This application closes on Sept 15! If you're interested in a computational postdoc position in my lab, please apply here! Lots of fun science :)

Jason Nomburg@jnoms.bsky.social · last mo.

I am hiring a computational postdoctoral fellow or bioinformatics scientist! Please apply here if interested, or share with anyone who may be. This position will be following up on our work studying the virus-host conflict. Reposts appreciated! aithyra.onlyfy.jobs/en/job/v2gwu...

Congratulations! Beautiful work. I know Mafalda and @m1quelag.bsky.social found it a pleasure to review.

Yun S. Song@yun-s-song.bsky.social · 2d ago

We are thrilled to share that our GPN-Star manuscript is now published and freely available: doi.org/10.1038/s415... (1/n)

🧵 Introducing Karenina, an open-source framework to evaluate LLMs & agents: doi.org/10.64898/202...

Fucoidans from brown algae and diatoms drive marine carbon sequestration partly because they're hard to break down. Sichert et al. show how synergistic interactions between degraders are critical for their degradation, giving insights into ocean carbon cycling www.nature.com/articles/s41...

Synergistic degradation of fucoidans in the ocean - Nature

Efficient degradation of fucoidans depends on complementary bacterial guilds that cooperatively break backbone and side-chain sugars, revealing a conserved, globally relevant mechanism that shapes mar...

nature.com

I made a presentation to other faculty about recent progress in general AI, to facilitate the discussion around the impact for research and teaching in biology. It could be that the slides are useful for others trying to do that same. Feel free to re-use. docs.google.com/presentation...

generalAI_for research_intro.pptx

Recent AI developments and what they mean for us Quick primer on general AI models* State-of-the-art in AI agent capabilities AI agents in biology (examples) Discussion - what does this mean for our r...

docs.google.com

Congratulations, Julia Mahamid! The EMBL scientist has been elected to Leopoldina, the German National Academy of Sciences, in recognition of her outstanding contributions to the field of structural cell biology. Learn more: www.embl.org/news/awards-...

We are hiring! Start at a #MaxPlanckInstitute with your own independent Max Planck Research Group. This position is equivalent to a W2 Professorship at a German university, or Associate Professor internationally. 🔗Apply until October 14th! www.mpg.de/career/max-p... #ScienceCareer #MPRG #TenureTrack

Chair in Bacteriology in Cambridge Department of Medicine. A great opportunity. Please circulate. www.cam.ac.uk/jobs/researc...

Even DeepMind scientists can get scooped sometimes

This is a VERY big one. (And yes, the fights over academic credit and what happened in the race for the proof needs to be resolved, but it is still appears that this is a big one, if true.) openai.com/index/navier...

On the Navier–Stokes Millennium Prize Problem

We’re sharing an AI-generated solution to the Navier–Stokes Millennium Prize Problem, including a writeup and a formal proof in Lean.

openai.com

The year is not over but 2026 is really the year of AI induced anxiety for me. Doomscrolling the latest general AI application examples hoping that maybe this time the update is a dud.

blog.google/innovation-a...

AlphaGenome Atlas: a high-resolution map of human DNA

We’re introducing AlphaGenome Atlas, a database predicting the effects of every possible single nucleotide variant in the human genome.

blog.google

The OpenFold team released the @openbind.bsky.social nbind.bsky.social model a few weeks ago. As we use AF3 for large co-folding runs, we still feel the gap in memory efficiency between OF3 and AF3. For this reason, we adapted the AF3 code to use the openbind weights openbind.uk/news/blog-op...

Two extraordinary charts from today’s PISA test results: 1) School test scores continue to collapse internationally, underscoring how this is no longer a Covid effect but sustained decline. Those falls in reading and maths are equivalent to about two years of lost schooling.

Wow! A lot of progress toward solving one of the Millenium Prize problems - proving blowup for Navier-Stokes. It involves AI, and the folks at OpenAI are battling the folks at Anthropic to get to the finish line first. For the math, read these posts by Terence Tao:

This interaction between OpenAI and mathematicians working on what seems to be an important discovery looks to be pretty bad cims.nyu.edu/~tristanb/st...

Nice new resource for getting into machine learning for biology 🧬 BioTorch has 116 hands-on PyTorch exercises covering models like AlphaFold2, ESM2, and RFDiffusion. Implement their basic building blocks, test your code, and see how the models work. It is free during beta! biotorch.chrishayduk.com

enews.embo.org?EventID=pc27... Registration is now open This EMBO Practical Course will provide an up-to-date overview of integrative modelling strategies with a focus on biomolecular dynamics. Special attention will be given to challenging systems where dynamics are essential for function

openai.com/index/resear...

Research acceleration: The view inside OpenAI

Inside OpenAI, coding agents are reshaping AI research. Explore early data on agent usage, experiment velocity, task complexity, and research acceleration.

openai.com

Another AI agent swarm cooperation example discovered on a wiki. That these things are not atracting more public discussion is beyond me. collusion.wiki

Discovery of a new OpenAI agent message board

A swarm of autonomous AI agents, self-identifying as OpenAI agents, used a small German volunteer wiki to save answers, coordinate live, and share sandbox bypasses. OpenAI noticed and said nothing.

collusion.wiki

I used Fable 5.1 to run an AI research project given a bioinformatics research idea (cross links +AlphafoldDB), with the objective of producing a submission folder (manuscript, figures, code, supplementary files, cover letter). It did so in about 7h with still fairly poor results. The process:

8.8% success rate for the ERC Starting Grant is not acceptable. It is a lottery at this point with so many great scientists and ideas left to be funded. We keep talking about the competitiveness of Europe and we can't agree to properly fund our best instrument for scientific innovation.

European Research Council (ERC)@erc.europa.eu · last wk.

📣 Good news! 📣 Results of the ERC 2026 Starting Grant call are out! Funding worth a total of €705 million will go to 421 early-career researchers across Europe. Discover who, what and where 👉 link.europa.eu/9M3MmN 🧪 #ERCStG #FrontierResearch #HorizonEurope 🇪🇺 @scienceinnovation.ec.europa.eu

Congratulations to @florianwollweber.bsky.social, the recently appointed Group Leader at EMBL Grenoble, who received an ERC Starting Grant worth approximately €2 million to investigate the origins of eukaryotic cell complexity. bit.ly/4gNwEBk

Big paper alert! This project has been years in the making. A comprehensive description of somatic mutation rates and signatures across 53 tissues or cell types using NanoSeq. A large collective effort led by Mimy Pham, Mike Stratton and @r-rahbari.bsky.social. www.biorxiv.org/content/10.6...

A comprehensive atlas of somatic mutation rates and mutational signatures in normal human cells

Over the course of a lifetime, somatic mutations accrue in normal human cells, causing variation in cell phenotype and engendering somatic evolution with outcomes ranging from the adaptive immune syst...

biorxiv.org

We are excited that our work describing DirectContacts2, a wiring diagram of human physical protein interactions, is published in @natcomms.nature.com . www.nature.com/articles/s41...

DirectContacts2: a wiring diagram of human physical protein interactions - Nature Communications

Knowledge of the physical interactions of proteins provides mechanistic understanding of their function. Here, the authors develop a machine learning classifier through the integration of 25,000 prote...

nature.com

The past, present and future of de novo protein design: www.nature.com/articles/s41... 🔓 rdcu.be/4JbZzMEqW9ra 🧬💻🧪

The past, present and future of de novo protein design - Nature

A Review of de novo protein design highlights key methodological advances and achievements, current challenges and future applications.

nature.com

Recruitment for the EMBL International PhD Programme is officially open! 📣 At EMBL, we train young scientists to become skilled and creative future leaders in academia, industry and other sectors. Start your career in the life sciences with us! 🔎 Read more and apply here: bit.ly/4x9Edss

“I’m an ML researcher, but I don’t know biology.” “I’m a life scientist or chemist, but I don’t code.” At #AITHYRA neither is a barrier. In fact, bringing different perspectives together is exactly what we value most. PhD Call in AI for Biomedicine: phd.aithyra.at #PhDProgram #AI #LifeSciences