After two fantastic days, I am looking forward to one more day with more incredible science at #SISB2026. I am excited to present a poster on my @embo.org postdoctoral fellowship project in the lab of @mfwhite2.bsky.social . See you at Poster #C7
Niels Schneberger
@nschneberger.bsky.social
Structural Biologist, Prokaryotic defense strategies and transporter protein enthusiast St Andrews, United Kingdom
I am thrilled to share that I was selected for an @embo.org Postdoctoral Fellowship. Soon, I will join the lab of @mfwhite2.bsky.social to study prokaryotic immune mechanisms. Super exciting!
🎬 Episode 12 of #SpotOnScience is out! In this episode, Sophie Binder from the group of Gregor Hagelücken introduces her work "The SAVED domain of the type III CRISPR protease CalpL is a ring nuclease". Check out the episode here: www.youtube.com/watch?v=cDTs... #science #research #immunology
Spot on Science, Episode#12, Sophie Binder / Self-regulation of protease CalpL by nuclease activity
YouTube video by Exzellenzcluster ImmunoSensation
youtube.com
Nature research paper: CARD domains mediate anti-phage defence in bacterial gasdermin systems https://go.nature.com/3CvoD3W
CARD domains mediate anti-phage defence in bacterial gasdermin systems - Nature
Caspase recruitment domains (CARDs) are present in defence systems that protect bacteria against phage, where the bacterial CARD domain is essential for protease-mediated activation of bacterial gasdermins that promote cell death.
go.nature.com
Out today @ Science: TIR signaling activates caspase-like immunity in bacteria We report a new immune signaling molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase Congrats Francois Rousset, Ilya Osterman and coauthors! www.science.org/doi/10.1126/...
Colored nuclei reveal cellular key genes The identification of genes involved in diseases is one of the major challenges of biomedical research. Researchers at the University of Bonn and the University Hospital Bonn (UKB) have developed a metho... weiterlesen
*Fully funded PhD position available in the lab* We will use structural proteomics to map the mechanosensitive interactions of talin in dendritic spines and how they change during long term potentiation. Please share, and email for details :) www.findaphd.com/phds/project...
BBSRC NWD: Structural Proteomics to spatially resolve interactions with mechanosensitive synaptic scaffold proteins at University of Liverpool on FindAPhD.com
PhD Project - BBSRC NWD: Structural Proteomics to spatially resolve interactions with mechanosensitive synaptic scaffold proteins at University of Liverpool, listed on FindAPhD.com
findaphd.com
Atomic structures of biological molecules have never been so available and ubiquitous, but this raises questions as to how they are made appropriately accessible for optimal use t.co/RTx2WLxR0W
Safer, nonradioactive staining alternatives for electron microscopy are introduced, simplifying sample preparation, reducing costs and making structural biology more accessible to researchers globally #NegativeStaining #ElectronMicroscopy doi.org/10.1107/S205...
The link to the github and colab notebook remains unchaged, we now however include a link to the design models and sequences which you can download here: github.com/martinpacesa... doi.org/10.5281/zeno...
GitHub - martinpacesa/BindCraft: User friendly and accurate binder design pipeline
User friendly and accurate binder design pipeline. Contribute to martinpacesa/BindCraft development by creating an account on GitHub.
github.com
Registration now open for the EMBO Workshop: Immune System of Bacteria !!!! www.sisb2025.conferences-pasteur.org/home Joins us in Institut Pasteur, Paris, April 8-10th.
Amazing work capturing NaDC3 in multiple states and with various substrates/inhibitors! Congrats Yan Li, Da-Neng Wang, Joe Mindell, and Bill Rice!! www.nature.com/articles/s41...
Substrate translocation and inhibition in human dicarboxylate transporter NaDC3 - Nature Structural & Molecular Biology
The authors show cryo-electron microscopy structures of the human high-affinity sodium–dicarboxylate cotransporter, responsible for dicarboxylate import into the cell, in complex with various substrat...
nature.com
#CASP16 results are in! Template-based VFold seems to be lead method for nucleic acid structure prediction! AlphaFold2 and 3 still seem to be best methods for protein monomer and complex prediction.
I’m very excitement to share a preprint of some very recent work from our lab on our continuing odyssey into the very interesting world of TAXI TRAP transporters. tinyurl.com/4a7fra4x 🧵 (1/9)
A new class of binding protein-dependent solute transporter exemplified by the TAXI-GltS system from Bordetella pertussis
Tripartite ATP-dependent periplasmic (TRAP) transporters are widespread in prokaryotes, but absent in eukaryotes, and facilitate the uptake of a wide variety of substrates. TRAP transporters are compo...
tinyurl.com
All cells are encapsulated by a membrane of complex lipidic composition, right? Not anymore! @JamesSaenz.bsky.social et al. show that a ‘minimal’ bacterial cell only needs 2 lipid species #microNatComms #Microbiology #CellBiology #lipids Read the paper: www.nature.com/artic...
A tuneable minimal cell membrane reveals that two lipid species suffice for life
Nature Communications - All cells are encapsulated by a membrane of complex lipidic composition, and understanding the roles of different lipids in membrane function is experimentally challenging...
nature.com
Congratulations to @philipphendricks.bsky.social for winning the #PosterPrize at this year's #ClusterScienceDays. Way to go Jimbo!
We identified a #VHH antibody that allosterically inhibits sialic acid binding by the #TRAP transporter #SBP VcSiaP. Thanks to the team including: @philipphendricks.bsky.social @scbinder.bsky.social @gavinhthomas.bsky.social @gha14.bsky.social Read the full story here: doi.org/10.1038/s420...
Allosteric substrate release by a sialic acid TRAP transporter substrate binding protein - Communications Biology
Biophysical and structural characterization of the TRAP transporter SBP SiaP in complex with a nanobody provides insights into an allosteric mechanism of inhibition.
doi.org