Next Wednesday we're running a live webinar on examining the genomes of examples of the 6 ESKAPE pathogens, using tools available in MORF Genomes. Come & learn about AMR gene and genomes using our visual browser-based tools. www.eventbrite.co.uk/e/how-superb...

How Superbugs Escape: Comparative Genomics of ESKAPE Pathogens with MORF

Dive into the sneaky world of superbugs and see how the MORF platform helps crack the code on ESKAPE pathogens' escape tricks.

eventbrite.co.uk

Delighted to share my first author paper on how the MIC10 protein complex generates curvature in mitochondrial crista out now in Science Advances!! 🥳🥳 www.science.org/doi/10.1126/... See below for a run through of why we were interested and what we found 👇

The molecular basis of mitochondrial crista formation by the MIC10 complex

Mitochondrial cristae are essential for respiration, yet the molecular basis of how the high curvature of these membrane folds is maintained remains unclear. Using structure prediction tools and multi...

science.org

It's out in @cp-structure.bsky.social! A fun process sorting out this puzzle with everyone in the @danengw.bsky.social group at NYUSoM! www.cell.com/structure/ab...

Structures of the human sodium-citrate cotransporter NaCT with and without substrates

Uptake of citrate by human NaCT is driven by a sodium gradient. Its sodium-substrate coupling mechanism is unclear. Sauer et al. determined cryo-EM structures of the protein in apo, in sodium, and in ...

cell.com

Our preprint is now published!

Nature Microbiology@natmicrobiol.nature.com · 2mo ago

Out Now! Quinone-transporting filaments expand bioenergetic capacity in Gram-positive Bacillota #MicroSky

Happy to see our NHE6 story published today in @natcomms.nature.com! Led by @lukasfeilen.bsky.social we reveal the #cryoEM structure, ion selectivity and regulation of the endosomal Na+/H+ exchanger NHE6, providing a framework for understanding Christianson syndrome. www.nature.com/articles/s41...

New paper on SLC10 (bile acid) transporters. Based on a 9-TM prokaryotic protein, ASBT_LB (same topology as mammalian ASBT) we show standard alternating access outward facing and inward conformations with a curious proteo-lipidic binding site for bile acids authors.elsevier.com/sd/article/S...

Bordetella pertussis BctCBA Mediates Citrate-Dependent Zn2+ and Ni2+ binding https://www.biorxiv.org/content/10.64898/2026.07.27.740893v1

Very pleased to share our recent work on sialic acid uptake in pneumococcus- a great team effort across @diamondlightsource.bsky.social @goetheuni.bsky.social @uniofstandrews.bsky.social and RCaH @instruct-eric.bsky.social www.nature.com/articles/s42... #glycotime

Streptococcus pneumoniae substrate binding protein SatA specifically recognises the α-anomer of N-acetylneuraminic acid - Communications Biology

The respiratory pathogen Streptococcus pneumoniae uses the substrate binding protein SatA of the ABC transporter SatBC–MsmK to specifically bind the α-anomer of N-acetylneuraminic acid, the immediate ...

nature.com

A water molecule is crucial to maintaining the structure and transport activity of VcINDY! academic.oup.com/pnasnexus/ad... Fantastic collaboration by the groups of @danengw.bsky.social (NYUSoM) and @chrismulligan.bsky.social (Univ. of Kent)

Functional role of a structural water in the elevator domain of dicarboxylate transporter VcINDY

Abstract. The divalent anion sodium symporter (DASS) family mediates the uptake of Krebs cycle intermediates and sulfate, and influences adiposity, insulin

academic.oup.com

Fun fact: Human NaCT/SLC13A5's mechanism for coupling sodium & substrate co-transport is distinct from its bacterial homolog VcINDY! A fascinating question to tease apart with @danengw.bsky.social and colleagues at NYU School of Medicine!

bioRxiv Biophysics@biorxiv-biophys.bsky.social · 3mo ago

Structures of the human sodium-citrate cotransporter NaCT with and without substrates https://www.biorxiv.org/content/10.64898/2026.07.08.737274v1

✨ So excited to share our latest preprint from the @corrylab.bsky.social & Lehane lab investigating resistance-conferring mutations in the malaria parasite lactate/H+ symporter, PfFNT 🔍 🦟 Here we show two new mutations, one of which is found outside the transport pathway 👀 tiny.cc/PfFNTresista...

A proton transfer mechanism in the malaria parasite lactate/H+ symporter reveals a channel-like transporter without conformational changes

The malaria parasite Plasmodium falciparum relies on anaerobic glycolysis for energy during the intraerythrocytic stage, producing lactate and H+ that must be extruded via its formate-nitrite transpor...

tiny.cc

Interested in joining our group in Oxford? We are looking for a PDRA with single particle Cryo-EM experience to help us figure out how sphingolipids are transported to the cell surface of Gram-negative bacteria. The deadline is 31st July. Informal enquires are welcome. Please share!

Read our new paper! We show how the protease BepA binds the BAM complex and undergoes striking conformational changes, embedding its water-soluble lid into the membrane to cleave outer membrane proteins. www.nature.com/articles/s41... #cryoEM #astburycentre

🚨 New in @natmicrobiol.nature.com! We reveal how the antibiotic target PBP1b fortifies the E.coli division site against osmotic rupture. Proud this was completed in our independent labs @dmf-unil.bsky.social, with @avettiger.bsky.social. Congratulations to all authors! 🦠❄️🔬 #teamtomo bit.ly/3SCbOg1 👇

The penicillin-binding protein PBP1b fortifies the Escherichia coli division site against osmotic rupture - Nature Microbiology

A specific isoform of PBP1b functions independently of the activator protein, LpoB, to drive generation of a wedge-like peptidoglycan structure that strengthens the division site in Escherichia coli.

doi.org

⏰ We have two exciting opportunities to join our team in Southampton! 🚀 𝐏𝐨𝐬𝐭𝐝𝐨𝐜𝐭𝐨𝐫𝐚𝐥 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡𝐞𝐫 (2 𝐲𝐞𝐚𝐫𝐬) 𝘈𝘤𝘪𝘯𝘦𝘵𝘰𝘣𝘢𝘤𝘵𝘦𝘳 virulence 👉 jobs.soton.ac.uk/Vacancy.aspx... 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐓𝐞𝐜𝐡𝐧𝐢𝐜𝐢𝐚𝐧 (3 𝐲𝐞𝐚𝐫𝐬) Engineering Biology 👉 jobs.soton.ac.uk/Vacancy.aspx...

Job Opportunity at the University of Southampton: Research Fellow

The McCarthy Lab has an exciting opportunity for a prospective Postdoctoral Research Fellow who is interested in understanding virulence and hospital persistence in Acinetobacter baumannii. The role w...

jobs.soton.ac.uk

Cool study on the evolutionary origin of a funky E. coli peptide transporter! #microsky

Our paper on the proton-driven secondary active #transporter SbmA for antimicrobial peptides is finally out! We used #cryoEM, #EPR, #MD to show that it resembles and undergoes conformational changes like #ABC transporter TMDs consistent with an alternating-access transport mechanism.

Chancie T@chanciet.bsky.social · 2y ago

Check out our new preprint on the bacterial secondary active #transporter SbmA.

Happy to see our work on SLCO2A1 with @smlea.bsky.social, Nakanishi and Newstead labs out now. Important insight into how prostaglandin and many drugs are transported. Hats off to @weitse-hsu.bsky.social for computational work! @oxfordbiochemistry.bsky.social www.nature.com/articles/s41...

Structural basis for prostaglandin and drug transport via SLCO2A1

Nature Communications - SLCO2A1 (also known as OATP2A1) is responsible for the transport of eicosanoids, including prostaglandins (PGs), as well as of a subset of nonsteroidal anti-inflammatory...

nature.com

Very excited that the first publication from my lab is now online! Thanks to @actacrystd.iucr.org editors and reviewers for the smooth publication process. And congratulations to first author, Jiayi Pan, who completed this work in her Master’s year! @biologyanu.bsky.social

Structural Biology@actacrystd.iucr.org · 7mo ago

Jiayi Pan et al.: Molecular structure and nickel-binding capacity of Proteus mirabilis UreE #Metalloproteins #NickelChaperones #ProteusMirabilis @ANUmedia...#IUCr https://journals.iucr.org/paper?S2059798326001907

And now published as an Observation! Many congrats to @weeboont.bsky.social for discovering that AsmA superfamily proteins, YhdP/TamB/YdbH, localize to the cell poles in E. coli, curiously AFTER division has occurred! 1/3 #MicroSky journals.asm.org/doi/10.1128/...

Polar localization of putative phospholipid transporters in Escherichia coli | mBio

The outer membrane (OM) of Gram-negative bacteria serves as an effective permeability barrier and confers intrinsic antibiotic resistance. This barrier function requires distinct distribution of lipid...

journals.asm.org

Shu-Sin Chng@figlegend.bsky.social · last yr.

@weeboont.bsky.social talked about our lab's recent preprint where we report AsmA superfamily proteins, believed to be phospholipid transporters, localizing to cell poles in E. coli. Really interesting observations, with impt implications for OM assembly! Read it 👇! www.biorxiv.org/content/10.1...

Fabian was quicker :) But yes, we have an open postdoc position in bacterial bioenergetics and membrane biology, using on B. subtilis as the model. Come join us! @cbcb-newcastle.bsky.social is a great place to work, and we are a friendly, international lab. Visa+IHS fees covered. #microsky

Molecular Microbiology@molmicrounihoh.bsky.social · 9mo ago

PostDoc position in Newcastle upon Tyne: @henrikstrahl.bsky.social

Structural elucidation of the hexameric MmpS4-MmpL4 complex from Mycobacterium tuberculosis https://www.biorxiv.org/content/10.64898/2026.01.07.698164v1

Deadline 7th Jan. See researches pages of @GavinHThomas (thomaslabyork.weebly.com), Emily Flack (york.ac.uk/biology/peop...) & Martin Fascione (fascionelab.com)

Thomas Lab @ York

Gavin Thomas lab in York

thomaslabyork.weebly.com

My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...

🚨My lab is hiring a postdoc!🚨 If you’re interested in working out the mechanism and physiological impact of bacterial lipid transport processes then please apply! Job advert is here: tinyurl.com/4swddfda Get in touch by email (c.mulligan@kent.ac.uk) for informal enquiries Please repost! Thanks!

My lab is hiring a postdoc! We have many exciting projects on membrane transporters at the interface of protein structure-function, bioinformatics, directed evolution, and protein engineering. Applications considered on a rolling basis, so submit ASAP. Please share! jobs.usf.edu/hcmUI/Candid...

Postdoctoral Scholar Research

The Reddy Lab at the University of South Florida (USF) is seeking a Postdoctoral Researcher to join our multidisciplinary team studying the structure, mechanism, evolution, and engineering of membrane...

jobs.usf.edu

The Gonzalez Lab at Columbia University is seeking a scientific leader! Join us in a Research Scientist position, driving single-molecule, structural, and biochemical studies of translation, translational control, and other RNA-based processes. Apply: apply.interfolio.com/176949

I'm happy to share that our work describing the #cryoEM #structure of the glycosyltransferase ArnC from Salmonella enterica has been published in Nature Communications. #membrane #protein #PetrouLab The article is open access and available at: www.nature.com/articles/s41...

Structural basis of undecaprenyl phosphate glycosylation leading to polymyxin resistance in Gram-negative bacteria - Nature Communications

The study reveals the structure of ArnC, a membrane glycosyltransferase that modifies undecaprenyl phosphate with aminoarabinose (L-Ara4N), leading to polymyxin resistance. The structure of ArnC in tw...

nature.com

We're advertising for a bacteriology technician and a post-doc to work on AI-guided antibiotic development as part of a large multidisciplinary Fleming Initiative project: www.imperial.ac.uk/jobs/search-... www.imperial.ac.uk/jobs/search-...

Description

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

imperial.ac.uk

Our paper on polymyxin interacting with the E. coli outer membrane is out! Simulations by the very talented @dheerajprakaash.bsky.social www.nature.com/articles/s42... To scale outer membrane protein island simulated at coarse-grained resolution with portions refined at all atom resolution.

Polymyxins slow down lateral diffusion of proteins and lipopolysaccharide in the E. coli outer membrane - Communications Biology

Multi-scale molecular dynamics simulations reveal that polymyxins form polymyxin-protein aggregates upon associating with the E. coli outer membrane thereby reducing lateral mobility of outer membrane...

nature.com