Tessera
Folgen

Ciara Wallis

@ciarawallis.bsky.social

PhD Student at the Corry Lab, ANU Enjoyer of pentagonal proteins, MD simulations, parasites, and frogs :))

10 Posts529 Follower1282 Folgt
Ciara Wallis@ciarawallis.bsky.social · 2mo ago

✨ So excited to share our latest preprint from the @corrylab.bsky.social & Lehane lab investigating resistance-conferring mutations in the malaria parasite lactate/H+ symporter, PfFNT 🔍 🦟 Here we show two new mutations, one of which is found outside the transport pathway 👀 tiny.cc/PfFNTresista...

A proton transfer mechanism in the malaria parasite lactate/H+ symporter reveals a channel-like transporter without conformational changes

The malaria parasite Plasmodium falciparum relies on anaerobic glycolysis for energy during the intraerythrocytic stage, producing lactate and H+ that must be extruded via its formate-nitrite transpor...

tiny.cc

@corrylab.bsky.social · 7mo ago

How does your immune system tell pathogenic RNA from your own, even though they’re made of the same stuff? Our latest paper with @gantierlab.bsky.social shows some self RNA act as an off switch preventing autoimmunity in the absence of pathogens. 🧬🔬⭐ www.nature.com/articles/s41590-026-02429-2

2′-O-Methyl-guanosine RNA fragments antagonize TLR7 and TLR8 to limit autoimmunity - Nature Immunology

Here, the authors show that 2’-O-methylated RNA fragments from ribosomal RNA naturally block TLR7 and TLR8, helping to avoid avoid harmful self-RNA detection and autoimmunity.

nature.com

@corrylab.bsky.social · last yr.

Excited to share John's new work in Nat Coms! We demonstrate how PfCRT, a polyspecific peptide transporter, turns into a drug transporter for antimalarials like chloroquine and why this causes a fitness cost for the malaria parasite (1/2) tiny.cc/PfCRT

@corrylab.bsky.social · last yr.

Bittersweet to announce the wonderful YC's final work in our lab. We are so proud of everything she's accomplished (incl. this beautiful study showing how the TAM complex facilitates lipid flow between the bacterial inner & outer membranes). We can't wait to see what you do next, Dr. Lin 🤩

YC Lin@yiechanglin.bsky.social · last yr.

1/ In my final project as part of the @corrylab.bsky.social, we show the bacterial TAM complex facilitates the spontaneous flow of phospholipids from the IM to the OM in MD simulations.. www.biorxiv.org/content/10.1101/2025.03.12.642747v1

YC Lin@yiechanglin.bsky.social · last yr.

3/ it feels significant to be writing this as i await my flight to be transported from the inner membrane (Canberra) I've called home for the last 8 years to the outer membrane (Beijing) of my next scientific adventure

BildBild
YC Lin@yiechanglin.bsky.social · last yr.

2/ ... discuss possible ways that lipids can be offloaded at the OM and use AF3 and MD data to suggest that other members of the AsmA-like protein family can accommodate lipids in their hydrophobic grooves

YC Lin@yiechanglin.bsky.social · last yr.

excited to share these results from a super fun AlphaFold project with @ciarawallis.bsky.social and welcoming examples of your favourite proteins with (possible or known) multiple oligomeric states for testing 👀👀

@corrylab.bsky.social · last yr.

Thrilled to share our latest preprint from @yiechanglin.bsky.social & @ciarawallis.bsky.social showing that AF2-Multimer and AF3 can quickly & accurately predict the oligomeric states & structures of proteins (& maybe can identify multiple biologically relevant oligomeric states 👀) tiny.cc/oligomers

Ciara Wallis@ciarawallis.bsky.social · 2y ago

I'm so excited to have been part of this very fun project in collaboration with the Zhang lab! 💻💙 Please check out our preprint on this beautiful channel-like protein called XPR1 here at www.biorxiv.org/content/10.1...

KIDINS220 and InsP8 safeguard the stepwise regulation of phosphate exporter XPR1

XPR1 is emerging as the only known inorganic phosphate (Pi) exporter in humans, critical for Pi homeostasis, with its activity stimulated by inositol pyrophosphate InsP8 and regulated by neuronal scaf...

biorxiv.org

@corrylab.bsky.social · 2y ago

Proud of our latest work w/ the Zhang lab showing from structure & simulation how XPR1, the only known human Pi exporter, is regulated by InsP8 & KIDINS220 + Pi selection & permeation through a channel-like “knock-kiss-kick” mechanism 🚪💋🦵 💻 by @ciarawallis.bsky.social & @riottowow.bsky.social

@corrylab.bsky.social · 2y ago

Excited to start the year with this paper with @elainetao.bsky.social. Using simulations we show sodium channel blocking drugs bind at many sites within the pore and fenestrastions rather than at a single distinct pose. @jgenphysiol.bsky.social @scienceanu.bsky.social #ionchannels hubs.la/Q031spy70

Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore

Tao and Corry investigate how the binding of sodium channel inhibitors to the Nav1.5 pore using simulations reveal promiscuous, polyspecific binding at the

hubs.la