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Innate2Adaptive research group @ UCL

@innate2adaptive.bsky.social

We aim to advance personalized/precision medicine for infections and cancer by improving diagnosis and patient stratification, and by driving innovations in vaccine design and immunotherapeutics. Website: https://www.innate2adaptive.uk/

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Mahdad Noursadeghi@mnoursad.bsky.social · last yr.

Interested in T cell immunity in TB? Check out our new pre-print on antigen-agnostic identification of generalisable human in vivo Mtb-reactive T cell responses: www.biorxiv.org/content/10.1... with @qimmuno.bsky.social & @innate2adaptive.bsky.social

Evolution of T cell responses in the tuberculin skin test reveals generalisable Mtb-reactive T cell metaclones.

T cells contribute to immune protection and pathogenesis in tuberculosis, but measurements of polyclonal responses have failed to resolve correlates of outcome. We report the first temporal…

biorxiv.org

Gabriele Pollara@gpollara.bsky.social · 2y ago

Really pleased to share collaborative project led by @emilybethwong.bsky.social & 1st author @maphemthembu.bsky.social A careful dissection of dysfunctional immune responses in ART-naive HIV infection. TL:DR bronchoalveolar ≠ blood responses #HIVSky #IDSky #ImmunoSky www.cell.com/iscience/ful...

Dysfunctional bronchoalveolar effector memory CD8+ T cells in tuberculosis-exposed people living with antiretroviral-naïve HIV infection

Immunology; Virology

cell.com

Mahdad Noursadeghi@mnoursad.bsky.social · 2y ago

Also out now.. after peer review, our analysis of blood transcriptional biomarkers of acute respiratory viral infection leveraging the SARS-CoV-2 human challenge model: www.nature.com/articles/s41...

SARS-CoV-2 human challenge reveals biomarkers that discriminate early and late phases of respiratory viral infections - Nature Communications

It’s not always clear whether blood biomarkers are differentially expressed in the time course of viral infections. In this SARS-CoV-2 human challenge study, the authors identify distinct single-gene ...

nature.com

Gabriele Pollara@gpollara.bsky.social · 2y ago

🚨 Delighted to share our paper defining a new role for IL-6 in TB. 🚨 We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB. Lead author @gushamilton.bsky.social #TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan... Thread 👇 (1/8)

Altered IL-6 signalling and risk of tuberculosis: a multi-ancestry mendelian randomisation study

Our findings propose a causal relationship between reduced IL-6 signalling and lower risk of tuberculosis, akin to the effect seen in other IL-6 mediated diseases. This study suggests that IL-6 antago...

thelancet.com

Gabriele Pollara@gpollara.bsky.social · 2y ago

Presented interesting paper in @innate2adaptive.bsky.social journal club today. Monocyte-T cell doublets in blood of TB & dengue pts - single cell transcriptional profiling: - activated cells - T cell-like monocytes & monocyte-like T cells Unclear functional role & if 100% not artefact #Immunosky

A novel method for characterizing cell-cell interactions at single-cell resolution reveals unique signatures in blood T cell-monocyte complexes during infection

Communication between immune cells through direct contact is a critical feature of immune responses. Here, we developed a novel high-throughput method to study the transcriptome and adaptive immune re...

biorxiv.org

Q-Immuno lab at UCL@qimmuno.bsky.social · 2y ago

📣 We are hiring! Postdoc opportunity in Quantitative Immunology at University College London. . 🔬 Develop computational approaches to discover clonal and functional T cell determinants of protection against Tuberculosis. Fully funded 2-year position. 🗓️ Apply by Dec 10 www.ucl.ac.uk/work-at-ucl/...

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

ucl.ac.uk

Gabriele Pollara@gpollara.bsky.social · 2y ago

More evidence of immune cell (macrophage) -> stromal cell (fibroblast) inflammatory communication to alter organ function (deleteriously, in this case) #ImmunoSky www.nature.com/artic...

Targeting immune–fibroblast cell communication in heart failure

Nature - A fibroblast lineage marked by FAP gives rise to POSTN-expressing fibroblasts resembling matrifibrocytes and IL-1β regulates FAP/POSTN fibroblast specification by directly signalling...

nature.com