Amazon really needs to up its game - kids are actually still at school!! Can we not even have a gap before thinking about planning the back to school bit?! 🙏

Disappointing data on meningitis vaccine preventing Neisseria gonorrhoea infections Then again negative trial data is as useful as positive findings, so that we focus resources most effectively #IDSky www.nejm.org/doi/full/10....

Meningococcal B Vaccine to Prevent Neisseria gonorrhoeae Infection | NEJM

No vaccines are currently licensed for the prevention of Neisseria gonorrhoeae infection. Observational studies suggest that the four-component meningococcal serogroup B vaccine (4CMenB) may reduce...

nejm.org

I haven't watched a football match for >24 hours now!!!😱 Life feels so empty.... (thankfully will get my fix again from tomorrow! 😅) #FIFAWorldCup

Excited to share this “Insight” @jem.org about an amazing new finding by Zhou, Zhang, Ye, Staeheli &co showing that type III interferons #IFNL also signal in #fibroblasts driving renal #fibrosis! #InterferonPower! #EveryCellIsAnImmuneCell! #FriendsOrFoes!

Journal of Experimental Medicine@jem.org · last mo.

IFNλ works at mucosal surfaces by signaling in epithelial cells and selected immune cells. Zhou, Zhang et al. (rupress.org/jem/article/...) demonstrate that IFNλ also signals in kidney fibroblasts sustaining renal #fibrosis. @lozanzi.bsky.social highlights the findings: rupress.org/jem/article/...

Great post @apsmunro.bsky.social! Doing more is such a natural reaction. But even 'benign' interventions may likely be harmful when tested properly. I'm yet to know of a trial for sepsis where adding antibiotics has been beneficial (outside of TB where we do it to prevent emergence of resistance).

Alasdair Munro@apsmunro.bsky.social · 2mo ago

My new post looks at two antimicrobials which have been routinely used and even recommended in guidelines despite a lack of RCT evidence In the last few weeks they’ve both been shown to have no benefit, and worse, high probability of harm - killing patients A lesson we keep failing to learn

"As longevity increases in Southern Africa, healthy-ageing interventions for tuberculosis survivors could improve function and survival into older age." #TBSky #IDSky by @kkranzer.bsky.social & team academic.oup.com/jid/advance-...

The 99% probability strapline is very well done .👏

CMI Communications@cmicomms.bsky.social · 2mo ago

🎙️ Just published Communicable E56: Frequentist vs Bayesian for clinical trial analysis – 99% probability you’ll want to listen to this Hosted by Emily McDonald & Josh Davis with invited guests Roger Lewis & Ian Marschner 🌟 Listen on #Communicable: https://share.transistor.fm/s/7ea020d2 #IDSky

A great episode to learn more about the current Ebola outbreak, if nothing else but to learn how to pronounce Bundibugyo #IDSky #IDEpi

CMI Communications@cmicomms.bsky.social · 2mo ago

🎙️ Just published Communicable E55: Bonus episode – Bundibugyo Ebolavirus outbreak Hosted by Angela Huttner and Anne-Grete Märtson with invited guests Daniel Bausch and Martin Grobusch 🌟 Listen on #Communicable: https://share.transistor.fm/s/8750e095

Fascinating paper. Not only association between auto antibodies against immunotegulatory IL-10 and some patients with inflammatory bowel disease. But also association between these antibodies and HLA risk allele for IBD. What's mechanistic link? #immunosky #MedSky www.nejm.org/doi/full/10....

Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease | NEJM

Neutralizing autoantibodies against interleukin-10 can result in a phenocopy of monogenic defects of interleukin-10 signaling in children and may be associated with inflammatory bowel disease (IBD)...

nejm.org

Run, cycle, or trek to support those affected by leprosy! Join our challenge events for unforgettable experiences that transform lives. Book your place today: www.lepra.org.uk/events/category/challenge-events #ChallengeEvents #RunForACause #CycleForChange #TrekForGood #MakeADifference

Fascinating paper. Not only association between auto antibodies against immunotegulatory IL-10 and some patients with inflammatory bowel disease. But also association between these antibodies and HLA risk allele for IBD. What's mechanistic link? #immunosky #MedSky www.nejm.org/doi/full/10....

Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease | NEJM

Neutralizing autoantibodies against interleukin-10 can result in a phenocopy of monogenic defects of interleukin-10 signaling in children and may be associated with inflammatory bowel disease (IBD)...

nejm.org

Our June issue is now live. The cover image puts microbes at play. Have your own fun and enjoyment reading the content within: www.cell.com/cell-host-mi...

The current #Ebola outbreak in DRC has the potential to be even larger than those in 2018 and 2014. Why have we seen larger outbreaks in recent years? There are multiple reasons including conflict, population movement and urbanization. But the trend shows we must learn how to respond better

The fine balance of prophylactic antibiotics. Prevent infections but are these infections significant and at what cost (resistance)? Here in stem cell transplants, but also relevant to other settings #IDSky #UTISky #AMR #ClinMicro academic.oup.com/ofid/advance...

Effect of quinolone prophylaxis discontinuation during pre-engraftment neutropenia on incidence, mortality, and aetiology of bloodstream infections in hematopoietic stem-cell transplant recipients: a ...

Our systematic review with meta-analysis suggests that discontinuation of quinolone prophylaxis during pre-engraftment neutropenia reduces bacterial resist

academic.oup.com

🆕💥🔴Review summarizes recent clinical trials for treatment of tuberculous meningitis 🔺Disappointing result:high dose Rifampin HARVEST 🔺The only adj Rx supported is dexamethasone(may not be universal: HIV+, ACT HIV, no survival benefit) 🔺Several ongoing RCTs #idsky www.tandfonline.com/doi/full/10....

An update on recent developments in the drug treatment of tuberculous meningitis

Tuberculous Meningitis (TBM) is an often lethal form of tuberculosis with damage to the brain resulting from a combination of direct effects from the causative pathogen M. tuberculosis and from the...

tandfonline.com

☀️ Don’t forget to sign for our next WEBINAR “Expert perspectives on Methenamine Hippurate for UTI prevention” ☀️ 🔜 24th June 13:00 CET ✍️ escmid.wufoo.com/forms/r1ijmo... 🥳 We are so excited to welcome you to another great ESGUTI webinar! Don’t miss out! #ESGUTI #IDSky #UTISky

So much we need to learn about tick-related infections, so this effort by HHS is welcome. But I worry deeply about the company they keep in their announcement. More here: #IDSky #Medsky voices.nejm.org/doi/full/10....

Lyme Disease Deserves Better — But Better Starts with Better Evidence

A recent federal announcement to combat tick-borne disease has a promising premise but deserves scrutiny.

voices.nejm.org

Excited to share my first-author research letter! Our findings highlight an important question: how therapies perform outside of clinical trials, particularly among patients often underrepresented in research. Thank you @jamanetworkopen.com! @unmccom.bsky.social @unmc-id.bsky.social

JAMA Network Open@jamanetworkopen.com · 2mo ago

In clinical practice, patients with #Bacteremia receiving dalbavancin were younger and more likely to have substance use or housing instability than those in the DOTS trial, but completed therapy with similar low failure rates. ja.ma/4odctAk

New post, on why solving maths won’t solve intelligence: kucharski.substack.com/p/solving-ma...

Solving maths won’t solve intelligence

History shows what happens when axioms hit reality

kucharski.substack.com

Window open on warm-ish, rainy, summer day = most enjoyable working conditions. Maybe rainfall sound is soothing / promotes concentration...

"In this proof-of-concept study, 4 months of delamanid, bedaquiline, and quabodepistat showed a promising end-of-treatment non-inferiority signal versus 6 months of RHEZ and was generally well tolerated." @thelancetinfdis.bsky.social #IDSky #TBSky www.thelancet.com/journals/lan...

Efficacy and safety of a 4-month quabodepistat, delamanid, and bedaquiline regimen for drug-susceptible pulmonary tuberculosis: a multicentre, open-label, randomised, proof-of-concept, non-inferiority...

In this proof-of-concept study, 4 months of DBQ showed a promising end-of-treatment non-inferiority signal versus 6 months of RHEZ and was generally well tolerated. Our results support further studies...

thelancet.com

Latest research from the lab out now. We examined the role and expression of fimbriae during UPEC bloodstream infection. A real team effort and brilliant collaboration with Mark Schembri’s lab in Brisbane. Thanks to the MRC and BBSRC for supporting our research @ukri.org

Yad fimbriae are triggered by host cues and enhance extraintestinal pathogenic Escherichia coli tissue colonisation during bloodstream infection

Author summary Extraintestinal pathogenic Escherichia coli (ExPEC) colonise the human gut without causing disease but can disseminate to the urinary tract and bloodstream. Understanding the mechanisms...

journals.plos.org

Very pleased the @who.int Programme Managers guide for control of scabies in low income settings now out. In many areas population prevalence of scabies is 10-30% making it a major public health problem. This guide is designed to assist Ministries of Health & NTD teams in scaling up interventions.

3HP with weekly text reminder vs 4R for #LTBI higher completion rate of 3HP (85%) vs 4R (65%) #IDSky #MedSky #TB #tuberculosis academic.oup.com/cid/advance-article/doi/10.1093/cid/ciag306/8678684

Three Months of Weekly Rifapentine and Isoniazid Versus Four Months of Daily Rifampicin for Tuberculosis Infection: A Randomized Controlled Trial

AbstractBackground. Treatment of tuberculosis infection (TBI) is a key pillar of the World Health Organization End TB Strategy. Two short-course rifamycin-

academic.oup.com

@tomgaymor.bsky.social what a time for American network to go on ad break. Missed it all! 😲

Intravital imaging showed these macs nibbling and engulfing live melanoma cells. This was independent of PS receptor MERTK. How are they able to recognise and phagocytose melanoma cells without opsonisation by antibodies? Can we exploit this for cancer immunotherapy? Lots to do! Please share! 2/2

It's been a while time to give #immunology @bsky.app another go...Thrilled to share work led by Dr Yuki Keith & colleagues @garvaninstitute.bsky.social, UNSW & Melanoma Institute Australia now out @jem.org. CD169+ macs in skin surround & constrain melanoma growth independent of T and B cells! 1/2

CSF1R-dependent CD169-positive macrophages locally constrain melanoma growth in the skin

Tissue-resident CSF1R-dependent CD169+ macrophages localize deep in the skin. They surround growing tumors and directly suppress their growth independent o

rupress.org

Amazing 😍 🔥SHORTEN 2 RCT A 7-day treatment course is superior to 14 days for uncomplicated Pseudomonas aeruginosa bacteremia, achieving similar clinical response rates with lower antibiotic exposure, fewer superinfections, and fewer serious adverse events #idsky @shorten2trial.bsky.social

this is cool - haematopoietic stem cell subsets that remember inflammatory cues. Link to human disease mortality a bit loose, personally, and not much functional readout of progenitor cells. Still, paper concept interesting, and yet another single cell popn to hunt in own datasets.... #ImmunoSky

Ivan Zanoni@lozanzi.bsky.social · 2mo ago

#WeekendRead! #EveryCellIsAnImmuneCell! #RememberMe! Xie, Zeng, Nagree, Jakobsen &co show @nature.com that upon TNF or LPS-driven inflammation, a subset of hematopoietic stem cells retains inflammatory epigenetic memory that can be transferred to immune cell progeny boosting all-cause mortality risk