Busquets-Garcia Lab
@bgarcialab.bsky.social
We are located in the Barcelona Biomedical Research Park. We want to better understand cell-type specific mechanisms underlying brain physiology and pathology.
🔔New from our lab! With @bolanosjuanp.bsky.social and Marsicano Labs, we show that adolescent THC induces a transient, sex-specific mitochondrial mechanism in astrocytes that drives lasting behavioral effects. Supported by @caixaresearch.bsky.social . www.nature.com/articles/s41...
A transient mitochondrial switch underlies long lasting effects of adolescent cannabis
Neuropsychopharmacology - A transient mitochondrial switch underlies long lasting effects of adolescent cannabis
nature.com
Today, Marc Canela defended his PhD on the Behavioral and Brain substrates of Second Order Conditioning. Congratulations for a great defense! It is the third thesis of the lab and I am really proud of each of these achievements as, being a PI, you can learn from each thesis.
Heading to Krakow to enjoy and learn from another @neuronusforum.bsky.social ! Tomorrow at 3:15 pm, I am chairing and presenting in the symposium "Higher-order conditioning: From incidental associations to psychotic-like states" which includes the talk from our PhD @imanzanaressierra.bsky.social.
New paper from the lab in iScience journal developed in the @HMar_research! We show how dentate gyrus & CA3 activity support second-order conditioning allowing learning without direct reinforcement. 🧠 Thanks to all people involved! Check it out: www.cell.com/iscience/ful...
Dentate gyrus and CA3 activity mediates light-tone second-order conditioning expression in mice
Neuroscience; Behavioral neuroscience; Systems neuroscience
cell.com
Excited to share that I’ve been nominated for Ordinary Member of the European Brain and Behaviour Society committee! Grateful for the opportunity to support and engage with this amazing neuroscience community.
@ebbsociety.bsky.social · 5mo ago🗳️ EBBS Elections are open! Members can vote to elect the next President and Ordinary Committee Member. Make your voice count and shape the future of our society. 👉 Vote and find all details here: ebbs-science.org/elections
🧠 ¡Abiertas las inscripciones para el XIV Simposio de Neurobiología (“Nuevas perspectivas en la investigación del cerebro" de la @SCB_iec! Ofrecemos becas para l@s soci@s de la SENC! ¡No te lo pierdas! #SENC
You invite somebody to give a talk at @researchmar.bsky.social. You had an amazing conversation during lunch. You start a collaboration. A postdoc @carlarduaso.bsky.social got nice results. You end up in an amazing paper. Congrats @jdejuan-sanz.bsky.social et al.!! www.nature.com/articles/s42...
Mitochondrial Ca2+ efflux controls neuronal metabolism and long-term memory across species - Nature Metabolism
Boosting mitochondrial metabolism in neurons in central memory circuits by enhancing Ca2+ retention in the mitochondrial matrix is shown to improve long-term memory formation in flies and mice.
nature.com
We did our Christmas lunch remembering the good and bad achievements of 2025. Celebrating one's and learning from the others. 2026 will be another exciting year for us. Very happy of the Christmas present I have received from my lab!! Proud PI :)
It was a pleasure to present some of our Lab projects on social cognition in the @neuroalc.bsky.social . I am very happy for the nice discussion at the end of the talk and also for the opportunity to learn from really exciting projects that are being developed in this neuroscience institute.
Instituto de Neurociencias CSIC-UMH@neuroalc.bsky.social · 9mo agoToday, we had the pleasure of hosting Dr. Arnau Busquets @bgarcialab.bsky.social from the Hospital del Mar Research Institute at #SeminarsIN with his talk: “Exploring the brain circuits underlying socio-cognitive behaviors in mice”. A fantastic lecture, thank you! 👏 @csic.es @dicv.csic.es @umh.es
After a constructive and extensive revision, happy to share our manuscript published in @elife.bsky.social entitled "Dorsal hippocampus mediates light–tone associations in male mice" (doi.org/10.7554/eLif...). Congrats to Julia Pinho, @carlarduaso.bsky.social and @imanzanaressierra.bsky.social.
Dorsal hippocampus mediates light–tone associations in male mice
A light–tone sensory preconditioning task in male mice is developed revealing sex differences and demonstrating that dorsal, but not ventral, hippocampal CaMKII-positive neurons encode innocuous stimu...
doi.org
Heading to another #SEIC2025 meeting in Madrid to celebrate the 25 years of this great, inspiring and constructive meeting on the cannabinoid-related research in Spain. Some of my best scientific memories come from this meeting.
Today, during the first meeting of the psychoneuroimmunology society held in Granada, our PhD student Irene Ferreres will be presenting our latest findings on the impact of adolescent stress on kynurenine metabolism in microglia and astrocytes. 📍 Poster 20 | 🕚 11:00–13:00
🎉 Happy to share the latest work published in @CurrentBiology from the Guillaume Ferreira lab where I collaborated! A big congrats to Guillaume and all people involved 👏 Check it out here: www.sciencedirect.com/science/arti...
Obesogenic diet impairs memory consolidation via the hippocampal endocannabinoid system
Although obesogenic high-fat/high-sugar diets impair memory function in humans and rodents, the underlying mechanisms remain elusive. Given that the b…
sciencedirect.com
When you start your lab, nobody has taught you how to supervise or overcome multiple difficulties of a PhD. I am happy that today the first PhD from my lab was well defended. Congrats Laura! Many thanks to @carlessaura.bsky.social , Ester Aso and @miriammelis.bsky.social for an inspiring discussion.
Tomorrow, I will be in Zaragoza participating to a new edition of the Research Career Course organized by the @academiajoven.bsky.social . During this course we will discuss about research funding, evaluation, dissemination, ethics, emotional management, among other important topics. .
Academia Joven de España@academiajoven.bsky.social · last yr.Por cuarto año consecutivo la @academiajoven.bsky.social organiza el Curso de la Carrera Investigadora en colaboración con @unizar.es y @csic.es 🗓️25 y 26 de septiembre 🏛️💻Presencial y online 📍Paraninfo @unizar, Zaragoza 👉Gratuito 👇👇 Más información e inscripción: academiajoven.es/proximos/iv-...
We are at @eurbehavpharm.bsky.social meeting ⛵️ Tomorrow @imanzanaressierra.bsky.social (Post. #1.7) and @carlarduaso.bsky.social (Post. #1.34) are presenting posters regarding the link between Cannabinoid drugs and Psychosis and Cannabinoid drugs and Alzheimer Disease, respectively.
Together with Giovanni Marsicano, @bolanosjuanp.bsky.social and @imanzanaressierra.bsky.social, we took profit of the #SENC2025 to have an exciting meeting with interesting findings from our @caixaresearch.bsky.social project, in which we are investigating the psychotic effects of cannabis.
Our group is in the #senc2025 meeting in Gran Canaria where we will show two different stories from the lab through the presentation of two posters.
🚨 New paper from our lab published in @cp-cellrepmethods.bsky.social and performed in the @researchmar.bsky.social led by our PhD student Marc Canela. 📄More info below: www.cell.com/cell-reports...
Profiling mouse behavior with computational tools to assess age-dependent differences in associative learning
Canela et al. introduce a data-driven pipeline to dissect second-order conditioning (SOC) behavioral responses in mice. Their work reveals that SOC elicits unique behavioral signatures depending on th...
cell.com
Our group is proud to have contributed to a new paper published in @nature.com led by @marsicano.bsky.social, in which MitoDREADD, a new tool to enhance mitochondrial activity, show promising effects against the cognitive decline in neurodegenerative disorders. www.nature.com/articles/s41...
Potentiation of mitochondrial function by mitoDREADD-Gs reverses pharmacological and neurodegenerative cognitive impairment in mice - Nature Neuroscience
Activation of Gs signaling at mitochondria by mitoDREADD-Gs increases mitochondrial metabolism, leading to better memory in mouse models of dementia, directly linking brain mitochondrial deficits to c...
nature.com
Very happy and honored that our ERASE project has been proposed to be funded by the @ageinves.bsky.social . 3 exciting years ahead to further investigate the brain substrates of emotion recognition in normal and pathological aging. #PID2024
The wildfire touching Marseille prevented me to be in the symposium, to share our project linking astrocytes, cannabinoid drugs and Alzheimer disease and to attend to the interesting @gliameeting.bsky.social ! I am sure the symposium conducted by @murphyroyallab.org has been a success!
Busquets-Garcia Lab@bgarcialab.bsky.social · last yr.Together with Ciaran @murphyroyallab.org, from the Université de Montreal, we are co-chairing today the Symposium "Understanding the roles of astrocytes in cognition and behaviour across the lifespan" in the @gliameeting.bsky.social in Marseille.
Together with Ciaran @murphyroyallab.org, from the Université de Montreal, we are co-chairing today the Symposium "Understanding the roles of astrocytes in cognition and behaviour across the lifespan" in the @gliameeting.bsky.social in Marseille.
Recycle your poster, share your research! New #Neuroscience event at @researchmar.bsky.social 🗓️ July 24 ⏰15:15h 📍Marie Curie Room 👩🔬 Keynote by Dr. Sara Mederos (@sainsburywellcome.bsky.social) 🔗 Register: forms.office.com/Pages/Respon... 👉 researchmar.net/agenda/968 @bgarcialab.bsky.social
🧠 How does the brain make decisions based on indirect associations between stimuli? 🔬 A new @pnas.org study led by Dr. Busquets @bgarcialab.bsky.social (@researchmar.bsky.social) sheds light on the role of the amygdala and cortical circuits 👉 researchmar.net/news/732/ @hospitaldelmar.bsky.social
Heading to the @ebbsociety.bsky.social meeting in Bordeaux to enjoy 4 days in a fantastic city, meeting colleagues and friends and enjoying a great scientific program. Our lab will contribute showing our different research lines.
Our PhD Jose Antonio González Parra and postdoc Irene Ayuso are attending the European Social Club meeting in Coimbra. Today, during the poster session, we have shown our interesting results on the brain circuits controlling emotion recognition in mice. #socialbehavior #mousebehavior #neuroscience
Did you ever wonder why we often feel ungrounded attraction or aversion by certain places, smells, or foods? Our brain does that by infering value from indirect associations in a process called higher-order conditioning. 🧵Here’s what we found using an specific paradigm in mice:
💼 Becoming a PI – how to get funding 💶 🗣️ @bgarcialab.bsky.social, Mara Dierssen, @sdelcilab.bsky.social & @marcsuarezcalvet.bsky.social 📆 June 3 - ⏰ 15:00 CET 📍#PRBB Marie Curie room ℹ️ Registration: bit.ly/careermonth25
