#bioGUNE_Seminars | 🗣️ “From Supramolecular Chemistry Towards Adaptive Chemistry” by Jean-Marie Lehn from Université de Strasbourg CNRS 📅 Thu, Oct 1 🕛 10:30 📍 #CICbioGUNE, Bldg 800 – Atrio 800 📅 More seminars: https://www.cicbiogune.es/activities
Joseph Schacherer
@schacherer.bsky.social
Genetics, genomics and yeast lover Professor of Genetics, Strasbourg University
New paper out in Yeast: Fellipe de Mello & team established a collection of ecologically diverse Brazilian yeasts and screened their performance in industrially relevant conditions, discovering some species that could be used for industrial applications 🇧🇷 onlinelibrary.wiley.com/doi/10.1002/...
Screening of Brazilian Isolated Yeasts Reveals Multiple Potential Chassis for Industrial Biotechnology
Harnessing Brazilian microbial diversity, comprehensive phenotypic screening of 79 yeast isolates identified non-conventional strains with superior multi-stress tolerance and metabolic versatility co...
onlinelibrary.wiley.com
Exciting news: @uwgenome.bsky.social will be hiring for two tenure-track faculty positions this year, one open rank and one assistant professor. Both are “Genome Sciences” interpreted broadly so we welcome applicants working in a variety of fields and methods. Ad will be out shortly.
Hey! You can have a look at our new preprint on #CellCycle regulation and #Pluripotency! A little thread 100% human 0% AI slop is coming (bear with me the mistakes). Let's thank first @maulik_nariya, the fantastic postdoc that led this project: www.biorxiv.org/content/10.6...
Comparison of cell-cycle gene expression dynamics and mRNA kinetics across mouse and human pluripotent systems
Cell-cycle remodeling is fundamental to pluripotency and lineage commitment, yet whether its transcriptional and post-transcriptional architecture is conserved across species and developmental states ...
biorxiv.org
🍷🧬 Save the date! #ICYGMB2027 the 33rd Int'l Conference on Yeast Genetics & Molecular Biology comes to Porto, Portugal, July 19-22, 2027! A stellar international lineup of speakers + 16 workshops across yeast biology. Full details 👉 www.i3s.up.pt/ICYGMB2027 #YeastGenetics
To test these ideas, we used a collection of wild S. cerevisiae isolates, initially assembled by the @schacherer.bsky.social #haploteam lab (www.nature.com/articles/s41...) and subsequently barcoded by Abhishek and Marion for their recent paper: www.nature.com/articles/s41...
Genome evolution across 1,011 Saccharomyces cerevisiae isolates - Nature
Whole-genome sequencing of 1,011 natural isolates of the yeast Saccharomyces cerevisiae reveals its evolutionary history, including a single out-of-China origin and multiple domestication events, and ...
nature.com
I’m excited to share our preprint with @oliviamghosh.bsky.social, where we explore what it takes to ‘win’ in long-term evolutionary competition: www.biorxiv.org/content/10.1...
Adaptive evolution can overwrite initial natural fitness variation only in highest-fitness yeast isolates
The fitness of an organism determines its likelihood of succeeding in short-term competition, but many other factors can influence its long-term success. In this study, we investigate the relative con...
biorxiv.org
It’s almost time! Join 2026 GSA Medal recipient @schacherer.bsky.social next week on September 15 to learn how pangenomics, long-read sequencing, and deep phenotyping are revealing new insights into the genetic basis of complex traits and missing heritability. 🔗https://buff.ly/SsNmgsN
Latest in #GENETICS: Read the inspiring journey of the Genetics Society of America Medal awardee @schacherer.bsky.social and learn about his contributions to #yeast research, including leading the 1000 Yeast Genomes Project. 🔗 buff.ly/V5yPKkl
How does genetic variation shape complex traits? Join 2026 GSA Medal recipient @schacherer.bsky.social of @unistra.fr on September 15 at 1:00 p.m. EDT as he explores how pangenomics is revealing new insights into the genetic basis of complex traits. 🔗 buff.ly/0JCxhmI
Really proud of this piece, led by @timothyfuqua.bsky.social , finally published in GBE! Tim's post perfectly explains what it hopes to achieve.
Timothy Fuqua@timothyfuqua.bsky.social · last mo.@vakirlis.bsky.social and I are proposing a new term in the de-novo genes / molecular evolution cinematic universe. The term is: "Emergence Bias" and our perspective piece describing it was published in @genomebiolevol.bsky.social today! So, what is an emergence bias? (1/7)
Our deep mutational scan of G6PD is out in final form! @reneegeck.bsky.social did an incredible job on the project, & @dougfowler.bsky.social has been fantastic to collaborate with, as usual. Really gratifying to contribute functional evidence on VUS classification for G6PD deficiency. rdcu.be/fyTlf
Evidence for G6PD variant classification from multiplexed functional assays
rdcu.be
Excited to share this personal story published by @GeneticsGSA. A reflection on my journey in genetics, the many people who shaped it, the @haploteam and my enduring fascination with diversity. Thanks to everyone who has been part of the adventure! academic.oup.com/genetics/adv...
The genetics of the many forms of diversity
Abstract. The Genetics Society of America Medal honors an individual member of the Society for their contributions to the field of genetics at the midcaree
academic.oup.com
Excited to share our latest #haploteam paper! We developed a barcoded collection of 520 natural yeast isolates to screen 600+ compounds at population scale, uncovering how natural genetic variation shapes chemical responses. Congrats to Abhishek and Marion, who led this work! doi.org/10.1038/s414...
Population-scale chemical response revealed by a barcoded yeast collection - Nature Communications
The authors created a barcoded collection of 520 wild yeast strains and screened them against over 600 compounds, revealing how natural genetic variation shapes compound resistance and identifying gen...
doi.org
Our laboratory is looking for a PhD student in Functional Genomics (fully funded position). Expected starting date: Oct 2026 More info here: www.igbmc.fr/en/igbmc/lif... Please share 📨
IGBMC: PhD position available in Raphaël Pantier's lab
igbmc.fr
IGBMC@igbmc.bsky.social · 2mo agoPhD position in Functional Genomics, in Raphaël Pantier's lab: Interplay between transcription factors and genome architecture in embryonic stem cells more info : amethis3.unistra.fr/amethis-clie...
Nice write-up of our latest paper: news.uark.edu/articles/82610 And could not have been done without the support of NSF and NIH.
New Study Finds Heat Shock Can Drive Changes in Protein Modifications
Research provides insight into how yeast cells respond to stressful conditions with implications for larger organisms that share the same proteins.
news.uark.edu
Jeff Lewis@lewislab.bsky.social · 3mo agoExcited to share the published version with some added experiments and analyses: link.springer.com/article/10.1...
Oh. Looky here #SciSky. New work from former PhD student Sabrina Chau along with our collaborators in the Laxman lab. A couple of main points: 1. Attenuation of a yeast dsRNA virus is accomplished through amino acid restriction.
Genetics Society of America@genetics-gsa.bsky.social · 3mo agoUsing genetic and biochemical experiments, @marcmeneghini.bsky.social and the team show how #yeast porin POR1 prevents an RNA mycovirus from accumulating to high levels in stationary phase cells following sustained culture. Read more in #GENETICS 🔗 buff.ly/UpebItI
Essays, written on the same occasion but a decade apart, by two lovers of genetics ❤️ @genetics-gsa.bsky.social @schacherer.bsky.social
Our new paper was, by definition, an adventure: stepping outside of our comfort zone, embracing the unknown, and engaging in activities where the outcome is uncertain. Includes discovery of a new species and working with a Native American tribe to name it… 🧵👇 onlinelibrary.wiley.com/doi/10.1002/...
Comparative Analysis of Stress Adaptation in the Yeast Microbiome of Cactus
Yeasts and related fungi isolated from cacti or nearby non-cactus plants were characterized phenotypically and genomically, revealing differences that hint at modes of adaptation to the cactus host.
onlinelibrary.wiley.com
Not being able to access the @ukbiobank.ac.uk is becoming a significant issue for a PhD student in our group and I can only imagine this is mirrored in many other places. It would be fantastic to at least have a timeline we could work with.
Our paper on the evolution of cellular miniaturization is now out in PNAS! www.pnas.org/doi/10.1073/... A short recap 🧵
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
pnas.org
Marco Fumasoni@marcofumasoni.bsky.social · 10mo ago🗞️ New preprint from the lab, led by our postdoc Ana Garoña (not on here) in collab with @andreagiometto.bsky.social: “Experimental evolution of cellular miniaturization reveals a mechanism for cell size evolution”, aka: “honey, we shrank the yeasts!” 🎥 www.biorxiv.org/content/10.6...
Congratulations to @schacherer.bsky.social @unistra.fr recipient of the #Yeast26 GSA Medal! Great to hear the journey to identifying structural variants in #1011YeastGenomes, tackling heritability, genetic diversity, and genotype-phenotype @genetics-gsa.bsky.social
Super excited to share our lab's work led by PhD student Margot Ruffieux on domestication of Saccharomyces cerevisiae, with a focus on sourdough and baking associated yeast! 🍞
biorxiv.org
14th Ekiden for the HaploTeam already - I can't believe it. But first since we moved to @igbmc.bsky.social! The competition between the Haplo and Diplo subteams was tough but as always, great fun and team spirit!
⏰ Only 2 DAYS left for early registration! Join us at #Yeast26 (June 13-17, Pacific Grove, CA) for cutting-edge research in #genetics, #genomics, #disease, #regulation, #systemsBiology, #cellBiology, #lifeCycle, #syntheticBiology, & more. Register by April 16 to save! 🧬 genetics-gsa.org/yeast-2026/
New from my lab: Ancestral sequence reconstruction analysis indicates the furin-cleavage-site insertion in the SARS-CoV-2 spike gene likely interrupted a codon academic.oup.com/ve/article/1...
Ancestral sequence reconstruction analysis indicates the S1/S2 insertion in the SARS-CoV-2 spike gene likely interrupted a codon
Abstract. The genome of the seasonal acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has a 12-nucleotide insertion that produced a furin cleava
academic.oup.com
🌊 Get ready for YGM2026- the ultimate #Yeast genetics experience! World-class science meets Pacific Grove paradise June 13-17 🏨 Stay on-site: deadline April 8 ⏰ Conference registration ends April 22 This is THE meeting you don't want to miss! We'll see you there! #Yeast26 #Asilomar #YeastGenetics
🎤 Meet the PYFF9 speakers! Yeast & Fungi Conference 2026 in Valencia (8–11 Sept) 📢 Registration & abstract submission open 🔗 yeastfungi.efbiotechnology.org/home #Yeast #Fungi #Biotechnology #CallForAbstracts @pyff-9.bsky.social
