HAHAHAHAHAHAHAHAHAHAHAHAHAHA! EPIGENETIC HULK LIKE THIS SMASH! NO SMASH NOTES! www.cell.com/cell-genomic...

Single-cell 3D genome imaging shows super-enhancer hubs are rare, nonspecific, and neither necessary nor sufficient for transcriptional bursting

Super-enhancers have been proposed to cluster in the nucleus when compared to other genomic elements. Le et al. found that super-enhancer clustering was rare and driven by non-specific interactions. P...

cell.com

A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵

Postdoctoral position in Neurodevelopment, in Juliette Godin’s lab: Species-specific mechanisms of ADAT dysfunction in brain development more info : seafile.igbmc.fr/f/6c8fc378b3...

12th Tri-Regional Stem Cell & Developmental Biology Meeting One day, three cities, one shared goal To showcase advances in cell, stem cell and developmental biology while fostering collaborations across Basel, Freiburg and Strasbourg. 12tri-regio2026.sciencesconf.org?lang=en

Our laboratory is looking for a PhD student in Functional Genomics (fully funded position). Expected starting date: Oct 2026 More info here: www.igbmc.fr/en/igbmc/lif... Please share 📨

IGBMC@igbmc.bsky.social · last mo.

PhD position in Functional Genomics, in Raphaël Pantier's lab: Interplay between transcription factors and genome architecture in embryonic stem cells more info : amethis3.unistra.fr/amethis-clie...

PhD position in Functional Genomics, in Raphaël Pantier's lab: Interplay between transcription factors and genome architecture in embryonic stem cells more info : amethis3.unistra.fr/amethis-clie...

🚨Preprint Drop🚨 We are very pleased to release our study on DNA methylation dynamics at enhancers during ESC differentiation! This work was led by Marlet Morales-Franco and Priscillia Lhoumaud 🧵(1/13) www.biorxiv.org/content/10.6...

Dual profiling of DNA modifications with enhancer features during the exit of naive pluripotency

Cis-regulatory elements, such as enhancers, play an essential role in coordinating gene expression programs during cellular transitions. As such, substantial efforts have been made to characterize enh...

biorxiv.org

1/🧵 Can transcription factor condensate formation be explained without phase separation? Our new preprint introduces SPARK, a simulation tool that reproduces condensate behavior (clustering, fusion, FRAP) from diffusion & binding kinetics alone. Movie: 60 sec FRAP sim www.biorxiv.org/content/10.6...

“failure of the research enterprise to provide the time and space for individuals to fail without fear of the consequences risks failure of a grander kind” www.nature.com/articles/d41...

We need to talk about failure in science

Failure is part and parcel of research, but discussing it sometimes seems to be taboo in science. It doesn’t need to be.

nature.com

🔬IGMM (CNRS/ Univ Montpellier) is hiring Group Leaders in Innovative Biology. @cnrsbiologie.bsky.social @cnrs.fr @umontpellier.bsky.social 📅 1 May–15 June 2026 📩 search2026@igmm.cnrs.fr 📎Full information 👇 #LifeScience #MolecularBiology #Research #PI #CNRS

We are looking for outstanding scientists to develop ambitious research programs in molecular and cellular biology, with special interest in multidisciplinary projects and computational biology.More info: www.i2bc.paris-saclay.fr #MolecularBiology #CellBiology #ComputationalBiology #TeamLeaders#I2BC

We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).

Much enjoyed this nice cryoEM study of NONO:SFPQ heterocomplex this morning, while it was snowing outside. So happy to read a paper in full again (only a handful of papers read in full in last weeks or even months ☹, and some were to review).

The gene-regulating proteins NONO and SFPQ assemble into ordered filaments - Communications Biology

Filament formation of full-length NONO/SFPQ heterodimers was observed and structurally characterized in vitro which may provide a scaffold for gene regulation, paraspeckle formation and DNA double-str...

nature.com

Postdoc position available in our lab @igbmc.bsky.social We have an exciting project aimed at re-visiting the (epi-)genomic functions of AT-binding proteins using state-of-the-art technologies: www.igbmc.fr/en/igbmc/lif... Expected start: from March 2026 Please share 📢

Single-Molecule DNA Footprinting and Transcription Imaging Reveal the Molecular Mechanisms of Promoter Dynamics https://www.biorxiv.org/content/10.1101/2025.11.26.690466v1

1/8🧵 Excited to share two studies in which I was involved within the Bird Lab📄📄 We have explored how the transcription factor SALL4 assembles and shapes chromatin in embryonic stem cells. @kashyapchhatbar.bsky.social @saragiuliani.bsky.social @drphcb-uoe.bsky.social @edinburghbiology.bsky.social

The IGBMC is recruiting a new Computational Biology Group Leader through the ENACT AI Chair for Scientific Discoveries, covering cancer, developmental, and structural biology. Join one of Europe’s leading life science centers! cluster-ia-enact.ai/appels-a-pro... Deadline: Jan 7, 2026

🚀 Excited to share my latest paper on using SHAP, to predict direct target genes of chromatin-associated factors! Check it out for insights into gene regulation and the power of explainable AI in genomics! #XAI #SHAP #Genomics doi.org/10.1371/jour... Let's break down what we found! 👇

Modelling transcription with explainable AI uncovers context-specific epigenetic gene regulation at promoters and gene bodies

Author summary Genes are turned on or off through complex processes involving many proteins that interact with DNA wrapped histones and modify their structure. These changes, known as epigenetic modif...

doi.org

1/5 Glad to share our latest work with Ian Chambers’ lab published @embojournal.org in which we investigated the role of TET DNA de-methylases during cell fate transitions. Great team effort, many thanks to Sara Gonzalez Brito @ebarbieri.bsky.social @edinuni-irr.bsky.social doi.org/10.1038/s443...

TET knockout cells transit between pluripotent states and exhibit precocious germline entry | The EMBO Journal

imageimageThe roles of TET DNA demethylases during early development remain poorly defined. This work uncovers independence of early mouse embryonic stem cell (ESC) transitions from TET proteins but a...

embopress.org

TET knockout cells transit between pluripotent states and exhibit precocious germline entry Ian Chambers and collaborators www.embopress.org/doi/full/10....

👉 The next TriRhena Gene Regulation Club takes place at the Friedrich Miescher Institute @fmiscience.bsky.social in Basel. 📅 Nov. 5th, 2025 (14:00-20:00) 📌 FMI, Basel ✍️ Registration deadline: Oct. 20th, 2025 Attendance is free 💸 , but registration mandatory: www.ie-freiburg.mpg.de/gene-regulat...

TriRhena Gene Regulation Club

The TriRhena Gene Regulation Club is a one-day symposium that brings together researchers from France (IGBMC), Germany (MPI-IE) and Switzerland (FMI) who share a common interest in gene regulation.

ie-freiburg.mpg.de

Check out our new collaborative preprint about Affinity-ligand purification of native human low-abundance multi-protein complexes doi.org/10.1101/2025...

Affinity-ligand purification of native human low-abundance multi-protein complexes for structure determination

In human cells, large multi-protein transcription co-activators, such as chromatin remodelers or histone acetyltransferases, play critical roles in gene-expression regulation and are often implicated ...

doi.org

Genetic gatekeepers of gametogenesis? TET proteins jointly jam germline specification, synergistically steering cells towards somatic fates. @justingutbio.bsky.social's new #preLight talks about the work of @r-pantier.bsky.social and the team. Have a look!

TET knockout cells transit between pluripotent states and exhibit precocious germline entry - preLights

Genetic gatekeepers of gametogenesis? TET proteins jointly jam germline specification, synergistically steering cells towards somatic fates.

prelights.biologists.com

Excited to announce I recently highlighted another preprint for @prelights.bsky.social. In this preprint, @r-pantier.bsky.social and co-authors from the Chambers Lab at the University of Edinburgh find that the TET proteins act together to help mammalian cells specify into somatic lineages.

TET knockout cells transit between pluripotent states and exhibit precocious germline entry - preLights

Genetic gatekeepers of gametogenesis? TET proteins jointly jam germline specification, synergistically steering cells towards somatic fates.

prelights.biologists.com

Excited our paper is out in Cell @cp-cell.bsky.social! 🧬⚡ DNA photo-crosslinking proteomics in living cells 🎯 Pinpoints protein-DNA interactions to single amino acids 🌎 Globally quantifies DNA binding for >1800 proteins at a timescale of minutes 🔗 www.cell.com/cell/fulltex... 🧵

The human proteome with direct physical access to DNA

Zero-distance photo-crosslinking reveals direct protein-DNA interactions in living cells, enabling quantitative analysis of the DNA-interacting proteome on a timescale of minutes with single-amino-aci...

cell.com

🚨 New preprint out! Do you think Single Molecule Footprinting and Fiber-seq are super cool but aren't sure how to unlock their full potential? HiddenFoot can help you: www.biorxiv.org/content/10.1...

Nature research paper: Low overlap of transcription factor DNA binding and regulatory targets https://go.nature.com/4jedGUz

Low overlap of transcription factor DNA binding and regulatory targets - Nature

A near-complete survey of transcription factor activities in Saccharomyces cerevisiae reveals that most transcription factors have both activator and repressor activities and limited overlap between their binding sites on DNA and regulation of nearby genes.

go.nature.com

🚨3 weeks left to apply!🚨 We’re hiring 2 new Group Leaders at IGBMC – early career researchers welcome 🌟 We offer salary support for up to 3 years while you secure a permanent position in the French system. Come join an international research environment in Strasbourg! www.nature.com/naturecareer...

Call For Two Group Leader Positions - Strasbourg-Ville, Bas-Rhin (FR) job with IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) | 12837602

The Institute of Genetics, Molecular and Cellular Biology (IGBMC) is seeking two outstanding group leaders to establish independent research teams.

nature.com

Hey! Check out our latest publication. A great collaboration with @longchrom.bsky.social and a nice example of how a negative result, the absence of a response to a transcriptional perturbation, can actually reveal an intriguing gene-specific buffering mechanism. www.science.org/doi/10.1126/...

Fully funded (at UK home rate) #PhD studentships to start 2025/2026 at University of Exeter, UK. #Chromatin #StemCells #Signalling #ProteinStructure #LineageCommitment #Transcription Please spread the word, and anyone interested please contact me. lsi.exeter.ac.uk/groups/hendr...

Hendrich Group - Starting Sept 2025 - Living Systems Institute - University of Exeter

LSI PHD studentship – start September 2025 or January 2026 Project 1: Title of Project: Control of chromatin remodeller activity...

lsi.exeter.ac.uk