Behind the scenes: Celebrating with Team Menon lab: From right to left, Dr Madhav C Menon (corresponding author), Gabriel C Barsotti, John F Pell (First author), EM Tanvir (co-first author) and Anand C Reghuvaran. And first author John Pell in the Lab.

How do high-risk APOL1 variants lead to kidney transplant rejection? doi.org/10.1172/JCI1... Madhav C Menon & team @yaleschoolofmed.bsky.social discover that APOL1 variants promote CD8 T-cell activation via Ca2+ signaling, causally explaining their link to kidney rejection. @the-asci.org

📣📣Announcing 🎉🎉 Arul M. Chinnaiyan, MD, PhD, and Charles L. Sawyers, MD, receive the 2026 Harrington Prize for Innovation in Medicine! See the interview on YouTube: youtu.be/JG-x6nnJi8E

ASCI Milestone Awards: 2026 Harrington Prize, Arul M. Chinnaiyan and Charles L. Sawyers

The American Society for Clinical Investigation (ASCI) honors Arul M. Chinnaiyan, MD, PhD, and Charles L. Sawyers, MD, with the 2026 ASCI/Harrington Prize for Innovation in Medicine. Drs. Chinnaiyan…

youtu.be

Perm1 has many cytoprotective and organ protective functions: doi.org/10.1172/jci.... Here, Sadoshima & team discover Perm1 reduces harmful stress and limits cardiac damage in mouse models of heart attack by enhancing Nrf2-driven antioxidant defense. @the-asci.org #Cardioprotection

The gut-joint axis & the effects of antibiotics: doi.org/10.1172/JCI2... @msdiamondlab.bsky.social & team @washumedicine.bsky.social find antibiotics-triggered changes in the microbiome worsen alphavirus-induced arthritis in mice by modulating infiltrating & resident immune cells in joint tissues

Proposing a diagnostic shift for the monogenic autoimmune disorder APECED: doi.org/10.1172/jci.... Lionakis & team find APECED is recognized earlier by expanding the diagnostic criteria to include 3 early manifestations—APECED rash, autoimmune enteritis & enamel hypoplasia.

SEC16B identified as a regulator of VLDL secretion and lipid accumulation in the liver: doi.org/10.1172/JCI2... Hossein Ardehali @hosseinardehali.bsky.social provides a commentary on Lu et al. doi.org/10.1172/JCI2... @the-asci.org

Providing valuable resources for the study of gastric cancer: doi.org/10.1172/JCI1... Yu Chen & team modeled gastric cancer progression with KO mice, finding deficiency of Kmt2c & Kmt2d led to dysplasia and loss of both genes with Pten resulted in invasive adenocarcinoma. @the-asci.org

This aging-related communication axis helps explain why older age increases MASLD incidence: doi.org/10.1172/jci.... Diehl & team @dukemedschool.bsky.social describe an inter-organ aging axis in which hepatocytes determine the rate of organ aging during metabolic stress in mice.

YPSA winner Michael G. Kattah 👇

Journal of Clinical Investigation@jci.org · 2w ago

Presenting a valuable intestinal cell atlas: doi.org/10.1172/JCI2... Michael G Kattah & team @ucsanfrancisco.bsky.social applied spatial gene mapping to archived colitis biopsies, identifying immune cell neighborhoods that explain why some patients are resistant to vedolizumab & others respond well

Can we reverse immunosuppression in glioblastoma? doi.org/10.1172/JCI1... Daniel J. Brat & team discover a pathway that glioblastoma cells use to activate macrophages and suppress anti-tumor immunity, revealing the PDPN-CLEC5A-Syk pathway as a potential therapeutic target. @the-asci.org

📣Now open: ASCI nominations for active and international membership for 2027 may be submitted Deadline: September 10, 2026, 11:59 pm EST. buff.ly/wmMYast

📣📣Announcing 🎉🎉 Kevin N. Sheth, MD, receives the 2026 Bruce F. Scharschmidt and Peggy S. Crawford Translational Medicine Award. In this highlight, Dr. Kevin Navin Sheth offers some words for the aspiring physician scientist. For the full interview with Dr. Anna Greka: youtu.be/lcaHk_Y9VKM

📗From our Special Issue on Fibrosis Robert Schwabe & colleagues provide a Review on the shared mechanisms of organ #fibrosis: doi.org/10.1172/jci.... @the-asci.org

New information on how estrogen impacts the heart: doi.org/10.1172/JCI2... Using iPCs and two rodent models, Kurt W. Prins @kurtprins.bsky.social @the-asci.org & team find estrogen exerts cardioprotective effects by regulating microtubules.

📗From our Special Issue on Fibrosis Benjamin D. Humphreys @humphreyslab.bsky.social provide a Review on the shared mechanisms of organ #fibrosis: doi.org/10.1172/jci.... @the-asci.org

Targeting gut microbiota offers a strategy for MASH doi.org/10.1172/JCI2... Y. Eugene Chen @the_asci.org & team show an ammonia-producing bacterium weakens the gut barrier & over activates liver immune cells in MASH models. And DT-109 lowered ammonia & improved disease

The 1st cellular and molecular analysis of the liver in pulmonary arterial hypertension (human tissue): doi.org/10.1172/JCI2... @kurtprins.bsky.social & team find PAH reshapes liver metabolism, inflammation & fibrosis in a manner distinct from NASH & Fontan-associated liver disease. @the-asci.org

Cellular plasticity as a therapeutic vulnerability: HNF4α is a key target in lung adenocarcinoma: doi.org/10.1172/JCI2... Raymond Ho and Jason C. Mills @the-asci.org provide a Commentary on Dadzie et al. doi.org/10.1172/JCI1...

Wearables support safer outpatient care for detection of cytokine release syndrome in patients with myeloma: doi.org/10.1172/jci.... Samir Parekh & team show wearable temperature sensors detected early signs of CAR-T treatment toxicity hours before standard hospital monitoring.

📣📣Announcing 🎉🎉 Julie Zikherman receives the ASCI/Marian W. Ropes, MD, Award In this video highlight, Dr. Zikherman discusses important factors during her training time. The full interview with ASCI President-Elect Dr. Julie A. Bastarache: youtu.be/TwsTQ8O4XZw

Beyond neuronal degeneration: oligodendroglial dysfunction as a driver of spinocerebellar ataxia type 1 pathogenesis Associate Editor Puneet Opal discusses compelling evidence from Lee et al. that substantially expands current models of SCA1 pathogenesis: doi.org/10.1172/JCI2...

Asparaginase is essential for acute lymphoblastic leukemia, but it is limited by drug-induced pancreatitis doi.org/10.1172/jci.... Sohail Z. Husain & team find early omics patterns in children with ALL & asparaginase-induced pancreatitis feature disrupted lipid–immune responses

The largest genomic study of young women with BRCA1 and BRCA2-associated #BreastCancer: doi.org/10.1172/jci.... Katherine L. Nathanson & team perform a comparative analysis of distinct genomic landscapes in young-onset gBRCA1/2 breast cancer.

ASCI member Rosas et al. report on its contribution to the profibrotic responses in activated lung fibroblasts & show macropinocytosis inhibition has potent anti-fibrotic effects in pulmonary fibrosis models: doi.org/10.1172/JCI1...

Positioning GSK3β as a promising therapeutic target for MASH: doi.org/10.1172/jci.... Here, ASCI member Samar H. Ibrahim & team report lipotoxic GSK3β activation in LSECs drives mitochondrial dysfunction and fibroinflammation in MASH.

NAD+ deficiency is associated with lung fibrosis Here, ASCI member Paul W. Noble & team boost a key NAD+ enzyme, NAMPT, to restore lung cell regeneration and reduce fibrosis, offering a potential treatment for idiopathic pulmonary fibrosis: doi.org/10.1172/JCI1...

In eosinophilic esophagitis loss of the epithelial protein SPINK7 drives pathogenesis. Marc E. Rothenberg & team report IL-13 and calpain-14 suppress the expression of SPINK7 by regulating OVOL1 in eosinophilic esophagitis: doi.org/10.1172/jci....

📣We're excited to announce an increase in JCI's impact factor to 14.3 (from 13.6, 2024). Thank you authors, reviewers, and readers!

📣We're proud to announce an increase in JCI Insight's impact factor to 6.8 (from 6.1, 2024). Thank you authors, reviewers, and readers!