Don’t miss your chance to present your poster at the 2027 AAP/ASCI/APSA Joint Meeting. Submit your abstract by Monday, Oct. 26th 11:59 PM ET. All career stages welcome! Video: Zachary M. Chan presenting his research project from Neil J. Kelly’s lab at the 2026 poster session. Info: buff.ly/Iq6VZFY

Katherine A. High, MD, is presenting our first Scientific Session of the 2026-2027 Academic year! Friday, October 23, 1-2pm Eastern. Moderated by David Ginsburg, MD Details and Registration: buff.ly/TaxfECb

📣 Deadline extension: The abstract submission deadline for 2027 AAP/ASCI/APSA Joint Meeting has been extended to October 26th! 👉 buff.ly/Iq6VZFY

The American Society for Clinical Investigation@the-asci.org · last mo.

📣 Call for posters: The ASCI is now accepting abstract submissions for the 2027 AAP/ASCI/APSA Joint Meeting Deadline: October 12, 2026 More info: buff.ly/Iq6VZFY

📣 Call for posters: The ASCI is now accepting abstract submissions for the 2027 AAP/ASCI/APSA Joint Meeting Deadline: October 12, 2026 More info: buff.ly/Iq6VZFY

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This is the home page for The American Society for Clinical Investigation website.

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ASCI member Chirag R. Parikh & team recently published in JCI Insight! In this peek Behind the Paper, authors Serena D. Souza and Wassim Obeid work on the new urine test that may help with earlier diagnosis for the rare kidney disease cystinosis in children 📎: doi.org/10.1172/jci....

📣 Nominations are OPEN for the 2027-2029 ASCI Postbaccalaureate Program!! 🔹 2 Postbacs Awarded 🔹 2 year laboratory research experience 🔹 ASCI-member lab 🔹 Immersive and mentored 🔹 MCAT and Med School Application Prep Learn more: buff.ly/uF7BsNQ

The ASCI Postbaccalaureate Program - The American Society for Clinical Investigation

The ASCI Postbaccalaureate Program page on The American Society for Clinical Investigation website.

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Suggesting a novel therapy for systemic sclerosis: doi.org/10.1172/jci.... @eduardomarban.bsky.social & team report that an orally delivered noncoding RNA (TY1) reduces inflammation and organ fibrosis in models of systemic sclerosis through inhibition of the cGAS/STING axis. @the-asci.org

📣 Nominations are OPEN for the 2027-2028 ASCI PSSF Fellowship Program!! 🔸 5 Fellowships Awarded 🔸 MD-or DO-only medical students 🔸 Med school research gap year (12 months) 🔸 Physician-scientist track 🔸 Immersive and mentored Learn More: buff.ly/0bsi5B8

ASCI PSSF Fellowship - The American Society for Clinical Investigation

ASCI PSSF Fellowship page on The American Society for Clinical Investigation website.

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Proposing a combination treatment for reducing death from cerebral malaria: doi.org/10.1172/JCI2... Alvin H. Schmaier & team report on a role for bradykinin in cerebral malaria and find plasma kallkrein inhibitors target host-mediated vascular dysfunction. @the-asci.org

Changing the paradigm for loss of the Y chromosome: doi.org/10.1172/jci.... Dan Theodorescu & team report Y chromosome loss increases progressively from healthy tissues to cancer, suggesting it is an early and previously unrecognized driver of cancer development. @the-asci.org

Congratulations to ASCI member Masashi Yanagisawa for the Lasker prize @laskerfdn.bsky.social! Mignot and Yanagisawa are recognized for their discovery of the role of orexins/hypocretins in wake, sleep, and narcolepsy. Yanagisawa previously presented at the ASCI scientific session: buff.ly/kJKbBLY

Masashi Yanagisawa, MD, PhD - The American Society for Clinical Investigation

Read more about Masashi Yanagisawa, MD, PhD at The American Society for Clinical Investigation

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Mignot and Yanagisawa win the Lasker prize from from @laskerfdn.bsky.social for discovery of the role of orexins/hypocretins in wake, sleep, and narcolepsy: doi.org/10.1172/JCI2... In this Viewpoint, Clifford B. Saper places Mignot’s and Yanagisawa’s discoveries in a historical context.

Alpha-Gal syndrome is a tick bite-associated allergy characterized by reactions to alpha-Gal found in red meat doi.org/10.1172/JCI1... Peter D. Crompton & team show the potential of alpha-Gal-specific mAbs to prevent the allergy by blocking IgE binding to alpha-Gal. @the-asci.org

Welcome to the kidney! R Ariel Gomez & team examine the role of renin cells in renal neurovascular morphogenesis & remodeling. The video: mouse kidney cortex with renin cells (magenta), the renal arterial tree (green), nerve fibers (yellow): doi.org/10.1172/jci.... @the-asci.org

Early signals shape cardiac macrophage phenotypes & repair outcomes: doi.org/10.1172/JCI1... Kory J Lavine & team traced monocyte differentiation trajectories after injury & identified an MHCIIhi population with an early IFN response signature associated with enhanced cardioprotection @the-asci.org

This proteomic score outperforms widely used clinical risk models: doi.org/10.1172/jci.... Corey et al. report on blood proteins that help predict heart disease risk in diabetes and are modified by GLP-1 therapy, improving risk assessment beyond traditional clinical factors. @the-asci.org

A new approach for kicking osteoarthritis: doi.org/10.1172/jci.... Wen Jiang @wenjiang-nano.bsky.social @mdanderson.bsky.social & team find blocking a key immune sensor, NOD2, in cartilage cells reduces joint damage in osteoarthritis mouse models. @the-asci.org

Reproductive life after In vitro fertilization: doi.org/10.1172/JCI2... JCI Editor Serdar E. Bulun discusses what the observations in mouse models from Rhon-Calderon et al. (doi.org/10.1172/JCI2...) might mean for human offspring born with IVF assistance @the-asci.org

Nominations are now open for ASCI’s 2027 Early-Career Awards (E-Gen & YPSA): buff.ly/Yv9Cmbb For early-career physician-scientists who have made notable achievements in their research, these awards encourage and inspire through broad participation in the ASCI physician-scientist community.

Anti-malaria mAb demonstrates durable protection in African adults doi.org/10.1172/JCI2... Peter D. Crompton & team assessed the phase II trial of CIS43LS, revealing that the long-acting mAb maintained over 80% protection through a single malaria season. @mmv.org @the-asci.org

A differential diagnosis for acute kidney injury: doi.org/10.1172/jci.... Chirag R. Parikh & team @kpmproject.bsky.social reveal that acute interstitial nephritis is a potentially common cause of acute kidney injury and sometimes not suspected by physicians. @the-asci.org

Saturday Spotlight💫 : When muscle membranes leak: doi.org/10.1172/jci.... Elizabeth M. McNally & team discover (mouse) muscle lacking two proteins critical for resealing damaged sarcolemma (dysferlin & annexin A6) cause leaky membranes and invite macrophages to come take a bite. @the-asci.org

Targeting GLP1R and IL17A suppresses obesity-induced leukemia in an oncogenic PTPN11 mutation-driven model: doi.org/10.1172/JCI2... @the-asci.org

JCI - Targeting GLP-1R and IL-17A suppresses obesity-induced leukemia in an oncogenic PTPN11 mutation–driven model

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Elevated mitochondrial protein import in acute myeloid leukemia increases reliance on mitochondrial protease LONP1: doi.org/10.1172/JCI1... By Aaron D. Schimmer & team @pmresearch-uhn.bsky.social @the-asci.org

JCI - Elevated mitochondrial protein import in acute myeloid leukemia increases reliance on mitochondrial protease LONP1

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Meet our 2026 ASCI Postbaccalaureate (Postbac) Scholars. Congratulations Madelyn Blake and Luisa Morgan!

What role does obesity play in promoting leukemia? doi.org/10.1172/JCI2... Kapur et al. uncover IL-17A driven, metabolism-coupled immunosuppression as a mechanistic link between obesity and SHP2-mutant leukemias & highlight a therapeutic strategy for patients with obesity.

Behind the scenes (Image 1/2): Sharing a glimpse of life in the Schimmer lab at Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. (Photography by Nathan Duong) Dr. Aaron D. Schimmer featured in image 2/2

Meet the 2026-2027 ASCI PSSF Fellows! Our 5 Fellows were drawn from an exceedingly talented group of candidates nominated by their medical school dean.

John K. Lee & team @fredhutch.org present a framework for combinations of Ab-drug conjugate targets & payloads that may be applied to improve metastatic, castration-resistant prostate cancer: doi.org/10.1172/JCI2... @the-asci.org

Behind the scenes: Celebrating with Team Menon lab: From right to left, Dr Madhav C Menon (corresponding author), Gabriel C Barsotti, John F Pell (First author), EM Tanvir (co-first author) and Anand C Reghuvaran. And first author John Pell in the Lab.