Whether you're falling in love with a person or with science… chances are you'll find yourself asking the same question at some point in your career... 😉

Silvia Ramundo@sramundo.bsky.social · 4h ago

“You blow a fuse Zing boom! The devil cuts loose Zing boom! So what's the use Wham bam! Of falling in love?” open.spotify.com/track/0OMNQy...

“You blow a fuse Zing boom! The devil cuts loose Zing boom! So what's the use Wham bam! Of falling in love?” open.spotify.com/track/0OMNQy...

It's Oh So Quiet

Björk · Post · Song · 1995

open.spotify.com

And finally a great one describing Human Behavior: open.spotify.com/track/5OnyZ5...

Human Behaviour

Björk · Debut · Song · 1993

open.spotify.com

And here another one of hers about seeing beauty in everyday, ordinary moments: “Venus as a Boy” open.spotify.com/track/5G9Lvz...

Venus as a Boy

Björk · Debut · Song · 1993

open.spotify.com

An Army of Me by Bjork! One of the best songs about tough love and self-reliance open.spotify.com/track/3vEmpJ...

Army of Me

Björk · Post · Song · 1995

open.spotify.com

I often find people who think as I do. Like this student in my microbiology course at the University of Canterbury. I talked about cotransduction in microbial genetics, and then bacteriophage therapy to fend off antibiotic resistant bacteria. The student drew this in class, and showed it to me.

What I loved most about UCSF (and what I’m trying to cultivate here @vbcscitraining.bsky.social ) is the genuine sense of flat hierarchy. I just found this picture of my son in Bruce Alberts’ office (to be fair, almost any adult or kid would be drawn to that office!). I was a random postdoc, 1/2

Did you ever want to sequence that one interesting cell you observed in your microscopy experiment? We have a new pre-print out today that describes a genetic barcoding method, Waldo, to perform live-cell imaging and single-cell sequencing on the same single cells. www.biorxiv.org/content/10.6...

Linking live-cell imaging to single-cell sequencing using genetic barcoding

Linking cellular phenotype to genotype and gene expression is a central goal in biomedical research. Live-cell imaging captures dynamic cellular phenotypes, whereas single-cell sequencing measures gen...

biorxiv.org

Delighted to share our lab’s latest paper, published in @science.org , uncovering a new role for Golgi-derived vesicles and phosphoinositides regulating mitochondrial fusion! 👇 www.science.org/doi/10.1126/...

Golgi-derived vesicles containing PI(3,4)P2 drive mitochondrial fusion

Mitochondria are dynamic organelles that remodel their shape to regulate cell fate. Mitochondrial division involves interactions with the endoplasmic reticulum (ER), lysosomes, and trans-Golgi network...

science.org

A big thank you to the one and only @harmitmalik.bsky.social for such a thoughtful and memorable gift and for an unforgettable collaboration at Fred Hutch’s Basic Scuences Division @basicsci.fredhutch.org ! We love you, Harmit! ♥️

Harmit Singh Malik@harmitmalik.bsky.social · 2d ago

Celebrating the 3 amigos on their paper identifying metazoan HJURP orthologs: @jeremyahollis.bsky.social (Malik/ Campbell labs), @irinakitop.bsky.social (Nic Lehrbach lab), Jason Stonick (Cecilia Moens lab). @basicsci.fredhutch.org Mugs: sciencegrit.com Paper: www.science.org/doi/10.1126/...

Application review for the GRC in Microbial Population Biology will start October 15th! Please apply before then if you are keen on coming. www.grc.org/microbial-po...

Challenge 3: functional integration. Rather than always inventing new genetic programs, nascent organisms often co-opt ancestral modules, turning environmentally induced cell states into spatially deployed cell types (e.g., Volvox regA, derived from a stress-response gene).

Challenge 2: the Darwinian threshold. Groups need a life cycle before they can evolve one, a classic chicken-and-egg problem. The way out: life cycles can be scaffolded "for free," either by the environment (e.g., floods dispersing cells) or by physics (packing stress fracturing snowflake yeast).

Challenge 1: forming groups. Across yeast, algae, bacteria and holozoans, lab evolution shows group formation arises fast (within 100–750 generations) and convergently, often through simple mutations like loss of ACE2 in snowflake yeast.

Multicellularity has evolved at least 45 times in eukaryotes alone, plus additional origins in bacteria and archaea. But how does it actually happen? We organize the paper around three perceived challenges: group formation, becoming a Darwinian individual, and functional integration.

Out today in @nature.com: our review on how single cells evolve into multicellular organisms. With Ozan Bozdag, @kaitong25.bsky.social, Peter Yunker, and @matthewherron.bsky.social. rdcu.be/9ZuiKow9twKa For an overview, check out the video below.

I'm not going to lie, this review puts the various challenges driving multicellularity very elegantly. For anyone excited about this field, this review is a must read. And damn this video is very very nice ! Congrats Will, Kai and Ozan.

Will Ratcliff@wcratcliff.bsky.social · 4d ago

Out today in @nature.com: our review on how single cells evolve into multicellular organisms. With Ozan Bozdag, @kaitong25.bsky.social, Peter Yunker, and @matthewherron.bsky.social. rdcu.be/9ZuiKow9twKa For an overview, check out the video below.

Looking to do a PhD in evolutionary cell biology, chromosomes & centromeres? 🧬🔬 The winter call for the UNIGE PhD recruitment is open, and my lab is among those recruiting through the Molecular Biosciences program! 🗓️ Apply by Nov 1st: lifesciencesphd.unige.ch

This work has been a massive team effort! I’m very grateful to all authors from @plaschkalab.bsky.social, our collaborators in @ameressl.bsky.social, @luijsterburglab.bsky.social and @romangp.bsky.social labs and for the generous funding from EMBO and HFSP. (11/11)

I’m very excited to share my postdoc work in the @plaschkalab.bsky.social, where we investigated the very final act of splicing – spliceosome termination, revealing the stepwise dismantling of the spent spliceosome www.nature.com/articles/s41... (1/11)

Mechanism of spliceosome termination - Nature

A coordinated sequence of RNA helicases and associated factors dismantles normal and defective spliceosome complexes to enable intron degradation and ensure accurate gene expression.

nature.com

After excising an intron, the spliceosome gets trapped on the branched intron-lariat RNA. How are such dead-end spliceosomes terminated? Our latest paper led by @vytaute.bsky.social investigates the mechanism of spliceosome termination www.nature.com/articles/s41... (1/6)

Together, our results point to convergent recognition of tobamovirus movement proteins by distantly related immune receptors. Their recognition ranges differ, and HREZ offers a complementary source of resistance to the pandemic virus. Preprint: www.biorxiv.org/content/10.6... (8/9)

Convergent recognition of tobamovirus movement proteins by phylogenetically distinct NLR immune receptors

The tobamovirus Tomato brown rugose fruit virus (ToBRFV) has rapidly emerged as a major threat to tomato production worldwide, overcoming the widely deployed Tm-22-mediated resistance and challenging ...

biorxiv.org

Then came the evolutionary surprise. HREZ and Tm-2² are not close relatives. They sit in distinct branches of the plant NLR immune receptor family. Yet both recognize tobamovirus movement proteins. Two evolutionary paths, one viral target. (5/9)

Hello World ! Its pre-print time ! Awesome collaboration led by Michel Cohen-Tannoudji (not on Bsky) and the one and only @deborahbourchis.bsky.social. #BFF We solved the molecular mechanism underlying a mysterious hybrid incompatibility in mice: the DDK syndrome. 🧵🍿 www.biorxiv.org/content/10.6...

Transposable Element insertions Repurpose Immune Endonucleases as Drivers of Reproductive Isolation in Mice

The emergence of reproductive barriers between closely related populations is a fundamental step in speciation, yet the underlying genetic mechanisms remain poorly understood in mammals. Here we resol...

biorxiv.org

We are updating our Expansion Microscopy (U-ExM) website with : - Protocols tips to help you get started - Examples of applications across different biological systems. - work in progress - an antibody database 👉 mocel.unige.ch/research-gro...

a fantastic new paper by lab alumni @codyz.bsky.social and yangliu9.bsky.social. Congratulations - such a cool mechanism! check it out 👇👇👇👇👇👇 www.sciencedirect.com/science/arti...

The Raman lab is open for business! Pravrutha is an amazing scientist and a wonderful mentor, so for folks who are interested in chromatin evolution and want to work across multiple model systems, this is a can’t miss opportunity. Spread the news!

Pravrutha Raman@pravrutharaman.bsky.social · 3d ago

Now that we have moved coasts, I am thrilled to share that the ChromEvo (Raman) lab is officially open at UMass Boston 🎉 We ask how CHROMatin EVOlution leads to functional innovation and we are hiring at multiple levels. Read on and share with folks who maybe interested chromevoramanlab.github.io

Now that we have moved coasts, I am thrilled to share that the ChromEvo (Raman) lab is officially open at UMass Boston 🎉 We ask how CHROMatin EVOlution leads to functional innovation and we are hiring at multiple levels. Read on and share with folks who maybe interested chromevoramanlab.github.io

Although I cannot say I am happy about anything that disassembles what I discovered as a PhD student (the U2-U6 structure at the heart of the spliceosome), I have to say this is a beautiful piece of work from the Plaschka lab. Congratulations to the authors! rdcu.be/S3duPskRLCJa

Whenever I see this poster, made to tease a visiting student in our lab, I can’t help but smile! Looking back on my own PhD days, even the toughest moments make me laugh now. And for the record, that student is now happily doing a postdoc! So there’s hope, even on those “I’m quitting science” days 🙃