Gabriel Esteban Valdebenito
@gabbov.bsky.social
Postdoctoral Fellow at MGH and Harvard Medical School 🇺🇸 Previously at University College London 🇬🇧
First preprint from the lab, led by @gabbov.bsky.social! We identify a metabolic bottleneck that helps set the pace of human development: low levels of the redox enzyme GPD1L limit NADH recycling. Boosting GPD1L mimics mouse cells and accelerates development! www.biorxiv.org/content/10.6...
biorxiv.org
Go check out @girishkalephd.bsky.social in preprints article, now out in @dev-journal.bsky.social! This is my first commissioned article as preprints editor (: thank you Girish! In preprints – light, cluster, friction: a cell dance on the gastrulation stage journals.biologists.com/dev/article/...
In preprints – light, cluster, friction: a cell dance on the gastrulation stage
Multicellular organisms, as the name suggests, are composed of many cells that work together. Cells need to stick together to ensure efficient cell coordination. Cadherins, which are calcium-dependent...
journals.biologists.com
Beautiful work into Vici Syndrome from @kritsh.bsky.social, investigating how pathogenic variants in EPG5 drive neurodegeneration through mitochondrial dysfunction and innate immune activation. @gabbov.bsky.social @chihyao.bsky.social @natcomms.nature.com www.nature.com/articles/s41...
Pathogenic variants in the autophagy-tethering factor EPG5 drive neurodegeneration through mitochondrial dysfunction and innate immune activation - Nature Communications
Mutations in the autophagy protein EPG5 cause multisystem disease, including neurodegeneration. This study shows that impaired mitophagy drives mitochondrial Ca2+ overload with permeability transition...
nature.com
Very cool to see more work exploring how NAD availability and redox state shape developmental tempo. Congrats to Nisha and Francois on this preprint!
Nisha Veits@nveits.bsky.social · last yr.How is developmental speed regulated ? 🪰 Happy to share my PhD story from Schweisguth Lab @devstempasteur.bsky.social. Here we show that cellular NAD+ availability and redox constrain developmental speed in the fly eye. www.biorxiv.org/content/10.1... A big thanks to everyone involved!
In preprints: setting the tempo of development @gabbov.bsky.social and @mdiazcuadros.bsky.social highlight two preprints that describe how developmental timing is set by cell-intrinsic mechanisms. journals.biologists.com/dev/article/...
New In Preprints from @dev-journal.bsky.social by Valdebenito & Diaz-Cuadros Highlights recent work investigating how the rate of development is controlled from @trayon.bsky.social & Coussement et al In preprints: setting the tempo of development url: journals.biologists.com/dev/article/...
In preprints: setting the tempo of development | Development | The Company of Biologists
journals.biologists.com
Thrilled to have written this piece for Development’s “In Preprints” series! I got to comment on two amazing preprints that explore how embryos set their pace of development. Check it out here 👇 👉 journals.biologists.com/dev/article/...
In preprints: setting the tempo of development | Development | The Company of Biologists
journals.biologists.com
Inhibition of the PI3K-AKT-MTORC1 axis reduces the burden of the m.3243A>G mtDNA mutation by promoting mitophagy and improving mitochondrial function www.tandfonline.com/doi/full/10....
Inhibition of the PI3K-AKT-MTORC1 axis reduces the burden of the m.3243A>G mtDNA mutation by promoting mitophagy and improving mitochondrial function
Mitochondrial DNA (mtDNA) encodes genes essential for oxidative phosphorylation. The m.3243A>G mutation causes severe disease, including myopathy, lactic acidosis and stroke-like episodes (MELAS) a...
tandfonline.com
📢New preprint alert 📢 Somite-independent regeneration of the axolotl primary body axis. biorxiv.org/content/10.110… This is the combined effort of a fantastic group of people over many years. Read below to see why you should care⬇️ 1/8
