Temperature scaling of developmental tempo reveals reaction-dominated morphogen patterning https://www.biorxiv.org/content/10.64898/2026.10.06.757014v1

First preprint from the lab, led by @gabbov.bsky.social! We identify a metabolic bottleneck that helps set the pace of human development: low levels of the redox enzyme GPD1L limit NADH recycling. Boosting GPD1L mimics mouse cells and accelerates development! www.biorxiv.org/content/10.6...

Go check out @girishkalephd.bsky.social in preprints article, now out in @dev-journal.bsky.social! This is my first commissioned article as preprints editor (: thank you Girish! In preprints – light, cluster, friction: a cell dance on the gastrulation stage journals.biologists.com/dev/article/...

In preprints – light, cluster, friction: a cell dance on the gastrulation stage

Multicellular organisms, as the name suggests, are composed of many cells that work together. Cells need to stick together to ensure efficient cell coordination. Cadherins, which are calcium-dependent...

journals.biologists.com

Beautiful work into Vici Syndrome from @kritsh.bsky.social, investigating how pathogenic variants in EPG5 drive neurodegeneration through mitochondrial dysfunction and innate immune activation. @gabbov.bsky.social @chihyao.bsky.social @natcomms.nature.com www.nature.com/articles/s41...

Very cool to see more work exploring how NAD availability and redox state shape developmental tempo. Congrats to Nisha and Francois on this preprint!

Nisha Veits@nveits.bsky.social · last yr.

How is developmental speed regulated ? 🪰 Happy to share my PhD story from Schweisguth Lab @devstempasteur.bsky.social. Here we show that cellular NAD+ availability and redox constrain developmental speed in the fly eye. www.biorxiv.org/content/10.1... A big thanks to everyone involved!

its lasers?

Insta Science@instascience.bsky.social · last yr.

A peacock showing off its art.

In preprints: setting the tempo of development @gabbov.bsky.social and @mdiazcuadros.bsky.social highlight two preprints that describe how developmental timing is set by cell-intrinsic mechanisms. journals.biologists.com/dev/article/...

New In Preprints from @dev-journal.bsky.social by Valdebenito & Diaz-Cuadros Highlights recent work investigating how the rate of development is controlled from @trayon.bsky.social & Coussement et al In preprints: setting the tempo of development url: journals.biologists.com/dev/article/...

Thrilled to have written this piece for Development’s “In Preprints” series! I got to comment on two amazing preprints that explore how embryos set their pace of development. Check it out here 👇 👉 journals.biologists.com/dev/article/...

Inhibition of the PI3K-AKT-MTORC1 axis reduces the burden of the m.3243A>G mtDNA mutation by promoting mitophagy and improving mitochondrial function www.tandfonline.com/doi/full/10....

Inhibition of the PI3K-AKT-MTORC1 axis reduces the burden of the m.3243A>G mtDNA mutation by promoting mitophagy and improving mitochondrial function

Mitochondrial DNA (mtDNA) encodes genes essential for oxidative phosphorylation. The m.3243A>G mutation causes severe disease, including myopathy, lactic acidosis and stroke-like episodes (MELAS) a...

tandfonline.com

Hi academic Twitter, I mean, bluesky people!

📢New preprint alert 📢 Somite-independent regeneration of the axolotl primary body axis. biorxiv.org/content/10.110… This is the combined effort of a fantastic group of people over many years. Read below to see why you should care⬇️ 1/8