How do cells integrate multiple signals into precise responses? Our study uncovers neuronal calcium sensor proteins as new regulators of adenylyl cyclase 8, linking GPCR-cAMP-Ca²⁺ signaling. @rflorea.bsky.social @dina-sch.bsky.social @psi.ch @eth-dbiol.bsky.social www.biorxiv.org/content/10.6...

We have started a project trying to predic the interactions/structures of all yeast protein pairs using an AlphaFold pooling approach. We are making the current dataset open and we welcome collaborations. www.evocellnet.com/2026/03/mapp...

Mapping the yeast atructural interactome with AlphaFold3: an open call for collaboration

We are excited to announce the early-stage release of our S. cerevisiae  structural interactome mapping project. Using AlphaFold3 (AF3), w...

evocellnet.com

Excited to share our new paper and lipid- and protein-directed photocatalytic labeling method (POCA) just out in @natchembio.nature.com. tinyurl.com/2kcxuvvv. Big congrats to first author Andrew Becker and the whole team for launching our lab into the wild world of singlet oxygen interactomics.

We’re delighted to report a global structural proteome analysis within living cells! doi.org/10.1038/s443... #proteomics #structuralproteomics #massspectrometry #structuralbiology #ethz @imsb-eth.bsky.social

#ICYMI The Chemoproteomics Group at the Nucleus, led by @dina-sch.bsky.social, uses mass spec-based techniques to study proteins & their molecular interactions. The group supports Stanford researchers throughout a project, from design consultation to data analysis.

Chemoproteomics Group at the Nucleus, Sarafan ChEM-H

The Chemoproteomics Group at the Nucleus, Sarafan ChEM-H, led by Dr. Dina Schuster, focuses on a wide range of mass spectrometry-based techniques to study proteins and their molecular interactions.…

youtube.com

Can we design mutations that bias proteins towards desired conformational states? Today in @science.org, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify conformation-biasing mutations.

Computational design of conformation-biasing mutations to alter protein functions

Conformational biasing (CB) is a rapid and streamlined computational method that uses contrastive scoring by inverse folding models to predict protein variants biased toward desired conformational sta...

science.org

My lab @stanfordmedicine.bsky.social is recruiting! We are looking for a postdoc at the interface of quantitative proteomics and G protein-coupled receptor (GPCR) biology: postdocs.stanford.edu/prospective/... #TeamMassSpec #Proteomics #GPCR #Postdoc

Come and join us @stanford-chemh.bsky.social! It's an amazing place to do interdisciplinary science & I'm so grateful to be in this community. Faculty applications due 10/15/2025 -- please share widely. Interested but not sure you're ready to apply this year? DM me & I'm happy to provide advice :)

Sarafan ChEM-H@stanford-chemh.bsky.social · last yr.

Open faculty position! We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa

Sarafan ChEM-H awards four $25K seed grants to fund collaborations w/ the new chemoproteomics group, led by @dina-sch.bsky.social at the Nucleus, a collection of labs that leverage scientific experts& advanced instrumentation to facilitate discoveries @stanford.edu chemh.stanford.edu/news/sarafan...

Sarafan ChEM-H awards four $25K seed grants to fund collaborations with the new chemoproteomics group at the Nucleus

The grants will give researchers access to advanced instrumentation and technical guidance for a variety of specialized proteomics techniques.

chemh.stanford.edu

Come work with us at the Nucleus @stanford-chemh.bsky.social! Happy to help you with proteome analyses, identifying your drug targets, understanding drug mechanisms, and much more 🔎🕵🏻

Sarafan ChEM-H@stanford-chemh.bsky.social · last yr.

The Chemoproteomics Group at the Nucleus, led by @dina-sch.bsky.social , uses mass spec-based techniques to study proteins & their molecular interactions. The group supports @stanford.edu researchers throughout a project, from design consultation to data analysis. chemh.stanford.edu/research/nuc...

‼️ Job alert 🚨: I have an open 3-year postdoc position in my lab to develop novel crosslinking mass spectrometry workflows. 🧪🧪 So if you want to do cool stuff in protein MS, please apply ! ⬇️ Please RT www.verwaltung.uni-halle.de/dezern3/Auss... #Academicsky #Chemsky #teammassspec

@davidsroberts.bsky.social, Andrew and I are our way to #ASMS2025 @asms.org 🥳 See you there? #massspec #teammassspec

Antibody–Drug Conjugate Stability Probed by Variable-Temperature Electrospray Ionization Mass Spectrometry #JASMS pubs.acs.org/doi/10.1021/...

Antibody–Drug Conjugate Stability Probed by Variable-Temperature Electrospray Ionization Mass Spectrometry

Antibody–drug conjugates (ADCs) are effective anticancer biotherapeutics, often referred to as “magic bullets” due to their high specificity and cytotoxicity. This unique drug class consists of cytoto...

pubs.acs.org

Ever wondered how stable your ADCs are and how their stability is influenced by their drug-load? Variable-temperature electrospray ionization can help with that! Jan Fiala’s and my postdoc work in the lab of @hecklab.bsky.social was just published! 🥳🥳🥳 pubs.acs.org/doi/10.1021/... 1/3

Antibody–Drug Conjugate Stability Probed by Variable-Temperature Electrospray Ionization Mass Spectrometry

Antibody–drug conjugates (ADCs) are effective anticancer biotherapeutics, often referred to as “magic bullets” due to their high specificity and cytotoxicity. This unique drug class consists of cytoto...

pubs.acs.org

Call for membrane protein mass spectrometry scientists! 🥼 I have the opportunity to write a short review on “Advances in Mass Spectrometry for Membrane Protein Pharmacology“, and I am looking for fellow membrane protein mass spec enthusiasts to contribute. 1/3

Please join us for proteoform Thurs this Thurs. Our former student, David Roberts will be presenting. David is a very talented young scientist and a great speaker. Please register using the link 👇 please help share @proteoforms.bsky.social @joelooucla.bsky.social ❤️

Consortium for Top-Down Proteomics@proteoforms.bsky.social · last yr.

Please join us May 15 for #Proteoform Thursday - David Roberts presents "Guiding the Rational Design of Protein Assemblies by Native Mass Spectrometry" #proteomics #massspec #nativems us06web.zoom.us/meeting/regi...

Great presentation on #FragPipe and its capabilities. Definitely learned a lot! Thank you @nesvilab.bsky.social for virtually stopping by to give a talk during our #proteomics users group meeting here @stanford.edu and for answering all our questions 😊 #massspec #teammassspec #StanfordProteomics

Excited to announce our revamped PhD-level BioMS course this September: Advanced Proteomics for Drug Discovery and Biotherapeutics Great line-up of instructors and topics, registration is open: www.hecklab.com/advanced-pro...

Lego mass specs will never get boring 🥰 Any guesses on which one I am assembling? #massspec #teammassspec

What a great month of science and inspiration as hosts of sabbatical visitor @hecklab.bsky.social, looking forward to our next encounters!

A few more spots are still open for some of the in-person programs at May Institute on Computation and Statistics for Mass Spectrometry and Proteomics on April 28 – May 11, 2025 on the campus of Northeastern University in Boston MA computationalproteomics.khoury.northeastern.edu

SCAM ALERT. This is a fake conference that ripped off my and other people’s names to trick people into registering. There is no such conference that I or the others shown were invited or agreed to. We are working to try to get this fraud taken down from the web. chemsymposia.com

Exploring the great California outdoors at the #Sunol regional wilderness preserve this weekend: lush green hills, beautiful wildflowers, lots of squirrels, and even a bobcat (!) - I’m a fan.

We are seeking to hire a lab tech, this is an HHMI funded position, please share the job posting: hhmi.wd1.myworkdayjobs.com/en-US/Extern...

Lab Administration Research Technician- Bertozzi Lab

Primary Work Address: Beckman Center, Stanford, CA, 94305-5323 Current HHMI Employees, click here to apply via your Workday account. We are currently looking for a highly motivated Lab Administration ...

hhmi.wd1.myworkdayjobs.com

Love Caltrain’s Swiss trains, almost feels like I am still in Switzerland🇨🇭

I had the opportunity to give my perspective to The Analytical Scientist about recent events. With this article, I hope to give a voice to others who may not have the ability to speak out. #StandUpForScience theanalyticalscientist.com/business-edu...

A Bleak Future?

Recent layoffs and funding cuts have not only crippled morale among scientists, they’ve also set an alarming precedent for the future of science

theanalyticalscientist.com

It is important at this pivotal moment to @standupforscience.bsky.social. Looking forward to sharing my thoughts on why this should be a national priority at tomorrow’s rally in SF:

Very excited to announce that I have moved across the pond to start my new position as Assistant Director for Chemoproteomics @ the Nucleus @stanford-chemh.bsky.social. This position allows me to do what I love: fun science, collaborations & teaching everyone about the wonders of #massspectrometry 🥳

I've been developing a semantic search tool that covers not just bioRxiv and medRxiv, but the entire PubMed database. This means you can search across a massive collection of biomedical research using keywords, questions, hypotheses, or even full abstracts. Try it out: mssearch.xyz

Another assault on US competitiveness at a time when biomedicine is roaring with innovation, an own-goal in a high-stakes international tournament. Of course the real losers are American people needing medicines and cures. www.washingtonpost.com/health/2025/...

NIH cuts billions of dollars in biomedical funding, effective immediately

The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.

washingtonpost.com