Nature research paper: Diverse binding poses of agonistic neurotoxins on human Nav1.6 go.nature.com/4eApyjD

Diverse binding poses of agonistic neurotoxins on human Nav1.6 - Nature

Structures of the distinct binding poses of three agonistic peptide toxins—bullet-ant-derived toxin δ-paraponeritoxin-Pc1a, cone snail ι-conotoxin RXIA and the globular β-scorpion toxin Cn2—on the human Nav1.6–β1 channel complex illustrate a diversity in binding poses and mechanisms of action.

go.nature.com

How do cells integrate multiple signals into precise responses? Our study uncovers neuronal calcium sensor proteins as new regulators of adenylyl cyclase 8, linking GPCR-cAMP-Ca²⁺ signaling. @rflorea.bsky.social @dina-sch.bsky.social @psi.ch @eth-dbiol.bsky.social www.biorxiv.org/content/10.6...

Happy to finally share the amazing results of our long-term collaboration with Karin Reinisch’s lab on how bridge lipid-transfer proteins (BLTPs) cooperate with partner proteins to orchestrate lipid delivery. A quick thread (1/7) www.biorxiv.org/content/10.6...

The best cover🥰, paired cats & paired helical filaments.

In our latest preprint on bioRxiv, we present the in situ structure of the human gap junction at 14 Å resolution using cryo-ET. The structure provides a blueprint for investigating how connexin regulation shapes intercellular communication in health and disease.

Ever wondered how stable your ADCs are and how their stability is influenced by their drug-load? Variable-temperature electrospray ionization can help with that! Jan Fiala’s and my postdoc work in the lab of @hecklab.bsky.social was just published! 🥳🥳🥳 pubs.acs.org/doi/10.1021/... 1/3

Antibody–Drug Conjugate Stability Probed by Variable-Temperature Electrospray Ionization Mass Spectrometry

Antibody–drug conjugates (ADCs) are effective anticancer biotherapeutics, often referred to as “magic bullets” due to their high specificity and cytotoxicity. This unique drug class consists of cytoto...

pubs.acs.org

I am delighted to share our findings on the binding mode of tetanus neurotoxin and the anti-epileptic drug Levetiracetam to SV2A, an essential synaptic vesicle membrane protein of unknown function, now online in @NatComms.bsky.social   www.nature.com/articles/s41...

Structures of native SV2A reveal the binding mode for tetanus neurotoxin and anti-epileptic racetams - Nature Communications

SV2A, an essential membrane protein in neurotransmission, is known as the receptor of clostridial neurotoxins and target of anti-epileptic drugs. Here the authors show details of the binding site for ...

nature.com

#CryoEM #structure of the botulinum neurotoxin A/SV2B complex and its implications for translocation. @NatureComms Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9f1r

nature.com

Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6

Delighted to share #AuthorInterview with @biopatrika.bsky.social were we discuss on recent findings on Botox. biopatrika.com/academia/res...

Molecular Snapshots Unravel Botox’s Secrets of Nerve Cell Entry - BioPatrika

Researcher Spotlight - In our study, we demonstrate for the first time the existence of large conformational changes in Botox and explain their purpose.

biopatrika.com

Coot 1.1.14 has been released! Coming to homebrew and flatpak soon! - Clark & Labute comes to Coot 1, Moorhen & chapi! (svg, 2D ligand environment view) - Solid Symmetry (symmetry that you can see!) - PAE plot for AlphaFold models #coot #molmatinf

Happy to share our latest publication on @naturesmb.bsky.social Natural Structure & Molecular Biology, we show tau filaments show Alzheimer fold in mutants V337M and R406W. thanks @sjorsscheres.bsky.social and Michel Goedert's support. 🥳 rdcu.be/edqzW rdcu.be/edoGv

Mutant tau filaments from some inherited frontotemporal dementias show the Alzheimer fold

Nature Structural & Molecular Biology - Frontotemporal dementias can be caused by mutations in MAPT, which encodes the protein tau; the mutant protein forms harmful aggregates in the brain....

rdcu.be

Very proud of our new review article on the Beta 1-Adrenergic GPCR now available on bioRxiv: www.biorxiv.org/content/10.1.... With @saureli.bsky.social @valeriorizzi.bsky.social and Nicola we used OneOPES to fully converge the free energy landscapes associated with B1AR apo/holo activation.

Nature research paper: Natural behaviour is learned through dopamine-mediated reinforcement https://go.nature.com/3XMKATn

Natural behaviour is learned through dopamine-mediated reinforcement - Nature

Studies in zebra finches show that dopamine has a key role as a reinforcement signal in the trial-and-error process of learning that underlies complex natural behaviours.

go.nature.com

Male blue-lined octopuses inject females with venom during mating to avoid being eaten by their partners https://go.nature.com/3FqtOU4

Bad romance: male octopuses inject deadly venom into their mates

The paralysing toxin deployed by the male blue-lined octopus might help to protect him from being eaten.

go.nature.com

Happy to share the beautiful structure of a Wadjet SMC complex by @roisnehamelinf.bsky.social, with support from the DCI and @drhonsworth.bsky.social ! This is a type II Wadjet with unique characteristics including a tandem KITE subunit, distinct coiled coil architecture and a deviant hinge.

Well said!!. I totally support this. As a collaborator or teamate and co coauthor, it's also our responsibility to ensure quality of Science in every publication we publish as coauthor. #SaveScienceFromJunk

Sjors Scheres@sjorsscheres.bsky.social · 2y ago

If you do an experiment for someone else's paper and you become a co-author, this means that you agree with *everything* in that paper! It takes time and effort to reach consensus, but this ensures better science. That's why I cannot understand how some people publish so many papers each year.

Hey kiddos. Don’t forget to filter your buffers and samples (any cut off is better than no cutoff) or use an inline filter on your systems!

We have deposited the following mice (all B6/J backcrossed) to @mmrrc.bsky.social Adgrf5-EGFP-CT-IRES-CRE GPR123- EGFP-CT-IRES-CRE GPR124- EGFP-CT-IRES-CRE GPR125- EGFP-CT-IRES-CRE Gpr133-EGFP-CT-IRES-CRE GPR156-IRES-Cre GPR156-mGL-IRES-Cre GPR75-IRES-Cre

The paper by @BasurajSK, Oneda Leka, Pal Sushant, @KorkhovLab, and Richard Kammerer (@psich_en), published in @NatureComms provides molecular insights in botulinum neurotoxin recognition and pH-dependent conformational transitions relevant to its mechanism of action. biol.ethz.ch/en/news-and-...

Symbiotic #bacteria ride along with single-celled #protists in ocean's upper layer phys.org/news/2025-02... #Symbionts of predatory protists are widespread in the oceans and related to animal pathogens www.cell.com/cell-host-mi...

Cryo-EM structure of the botulinum neurotoxin A/SV2B complex and its implications for translocation pubmed.ncbi.nlm.nih.gov/39934119/ #cryoEM

Want to know “How does #Botox enter cells at the right time & place to exert its #therapeutic effect?” Check out our latest paper @naturecomms.bsky.social @psich_en @KorkhovLab @ethzurich.bsky.social www.nature.com/articles/s41...

Love this.. 👏 MISO: Microfluidic protein isolation enables single particle cryo-EM structure determination from a single cell colony www.biorxiv.org/content/10.1...

Looking for a primer on why the contrast transfer function matters in #cryoEM? Have a look at our updated #CryoSPARC Guide pages on CTF estimation! We cover intuition, theory, job types and practical considerations: guide.cryosparc.com/processing-d...

How can medicines be directed to the precise location within the body where they need to act? Research lead by ETH Zurich have now unveiled a special class of effective particles. They appear visually striking under a microscope too, resembling tiny paper flowers or desert roses.

Delivering medicines with microscopic flowers

These small particles are reminiscent of paper flowers or desert roses. Physicians can use them to guide medicines to a precise destination within the body. Better yet, the particles can easily be tra...

ethz.ch