Relating to our recently published paper in @natneuro.nature.com! 🔥🚨 Find here a research briefing that we wrote w/ @djabaudon.bsky.social trying to reach a broader neuroscience audience! Enjoy the reading! www.nature.com/articles/s41...
nature.com
Denis Jabaudon
@djabaudon.bsky.social
Developmental neurobiologist, neurologist, & evo-devo aficionado. University of Geneva, Switzerland.
Interested in the mechanisms of neurogenesis, and how they might converge/differ across species, regions, and life epochs? Check this out, wonderful location and great science! Please RT neuro-unige.ch/news/csf-mee...
Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...
Cell-extrinsic controls over neocortical neuron fate and diversity
Cell-extrinsic cues are key for neocortical cell identity and diversity.
science.org
"You cannot not communicate". Paul Watzlawick. Highlights that all human interactions, even silence, are forms of communication and convey a message. Everything we do —or don't do — can be interpreted as communication by others. E.g. ghosting. There's no way out of being social.
Dear Reviewer #2, thank you for accepting to assess our revisions. After 60 days, the editor gave up, you never answered. The 1st author worked day & night to address your points, but you were too busy to even say no. The outcome is irrelevant, his disillusion isn't. Review responsibly, it matters.
Postdoc opportunity in the heart of Europe! Check out the flyer below. Join our team on an international project with Anthony Holtmaat exploring synaptic plasticity and specificity in cortical and thalamocortical circuits.
Brilliant @natneuro.nature.com by @scienceyael.bsky.social @lehtinenlab.bsky.social, uncovering “a fundamental secretory pathway in the Choroid Plexus that shapes brain development” in mice 🧪🧠 www.nature.com/articles/s41...
Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development - Nature Neuroscience
The choroid plexus (ChP) provides molecular cues for brain development. However, the underlying mechanisms are unclear. This study identifies an apocrine secretion mechanism in the ChP that modulates ...
nature.com
Still openings, check it out!
Denis Jabaudon@djabaudon.bsky.social · 2y ago🧠Job Opening!🧠 We are opening 2️⃣! positions – bioinformatics / molecular biology – in a project studying how temporal patterns set up connectivity in human brain tissue. @institutimagine.bsky.social. Full details below, contact me for details if interested. And please retweet (re-bluesky?)!
Success in academia often has more to do with luck, patronage and the job market than “hard work”. Good academics acknowledge this. I worked hard, but I was in the right place at the right time on occasion. Historians far more talented than I have fallen between the cracks.
"One day, when it's safe, when there's no personal downside to calling a thing what it is, when it's too late to hold anyone accountable, everyone will have always been against this." - Omar El Akkad
Ken Miller@kenmiller.bsky.social · last yr.75 days now of complete blockade/siege of Gaza. People are starving, babies elderly & sick already dying. Meanwhile Israel destroying what's left of Gaza so the living will have no place to return to. An atrocity for the ages and the world is so quiet.
🎉 Excited to share that our paper on FCDII is out today! 🙌🏻 Huge thanks to @sbaulac.bsky.social and @sara baldassari for bringing me on board and introducing me to the complexity of somatic mutations. Hope our work helps advance understanding of the disease mechanisms.
Nature Neuroscience@natneuro.nature.com · last yr.Single-cell genotyping and transcriptomic analysis reveals cell-type specific and non-autonomous effects of mTOR pathway mutations in mosaic focal cortical dysplasia type II (FCDII) 🧠🧪 www.nature.com/articles/s41...
Why does the forebrain expand dramatically while other neural regions grow less? Our new publication reveals progenitor metabolism critically shapes region-specific brain growth. Thread below. authors.elsevier.com/a/1k-udL7PXu...
#Standupforscience event today at Campus Biotech in Geneva. In solidarity for our colleagues in the US and in support of universal values of science: transparency, evidence, cooperation, and intellectual honesty.
Open positions in human developmental neuroscience, check it out!
Denis Jabaudon@djabaudon.bsky.social · 2y ago🧠Job Opening!🧠 We are opening 2️⃣! positions – bioinformatics / molecular biology – in a project studying how temporal patterns set up connectivity in human brain tissue. @institutimagine.bsky.social. Full details below, contact me for details if interested. And please retweet (re-bluesky?)!
Open positions in neuroimmunology in Paris, check it out!
Atypical functional connectome in congenitally blind humans doi.org/10.1101/2025...
Atypical functional connectome in congenitally blind humans
The cortex is organized along macroscale structural and functional gradients that extend from unimodal to transmodal association areas and from somatosensory to visual regions. It has not been tested ...
doi.org
Interesting study on cell-type-specific aging using single-nuclei transcriptomics in the human neocortex. Not clear to me based on this graph that pace of aging is striking different across cell types. doi.org/10.1101/2025... see also https://doi.org:10.1038/s41593-024-01742-z
Novel environment exposure drives temporally defined and region-specific chromatin accessibility and gene expression changes in the hippocampus. doi.org/10.1101/2024...
A bit of a spooky title, but nice ressource for longitudinal imaging of brain connectivity throughout life. Functional Hierarchy of the Human Neocortex from Cradle to Grave doi.org/10.1101/2024...
Long-term in vivo imaging of single neurons in the developing mouse brain from early postnatal days on. A game-changer in figuring out developmental trajectories. From the Cossart lab. doi.org/10.1101/2025...
In drosophila, by manipulating sets of surface proteins, you can re-engineer connectivity of olfactory neurons and generate a new neuron type that alters courtship behavior. Impressive work from the Luo lab. doi.org/10.1101/2025...
Rewiring an olfactory circuit by altering the combinatorial code of cell-surface proteins
Proper brain function requires the precise assembly of neural circuits during development. Despite the identification of many cell-surface proteins (CSPs) that help guide axons to their targets, it re...
doi.org
US stimulation (i.e. disruption) of specific thalamic nuclei in healthy humans affects arousal like behavior (central thal) and visual attention (pulvinar). doi.org/10.1101/2025...
Transcranial ultrasonic stimulation of central thalamus reduces arousal in healthy volunteers
We present the first causal evidence in healthy humans linking central thalamus to vigilance and pulvinar to visuospatial attention using low-intensity transcranial focused ultrasound stimulation (tFU...
doi.org
Delighted to showcase our atlas for the inference of ligand-receptor mediated interactions between neuronal subtypes during mouse cortex development. Herculean endeavor by former PhD student Rémi Mathieu (now @alleninstitute.bsky.social) and team, in collaboration with @LudovicTelley Thread 🧵
Today, we're launching the Arc Virtual Cell Atlas, a growing resource for computation-ready single-cell measurements. arc-website-git-ben-virtual-cell-atlas-tool-arc-institute.vercel.app/news/news/ar...
Arc Virtual Cell Atlas launches, combining data from over 300 million cells | Arc Institute
Arc Institute today launched the Arc Virtual Cell Atlas, a growing resource for computation-ready single-cell measurements, starting with data from over 300 million cells. The initial release of the A...
arc-website-git-ben-virtual-cell-atlas-tool-arc-institute.vercel.app
There are no ASD or ALS genes. Just like there are no ASD or ALS patients. There are genes associated with these diseases, and people with them. It's beyond semantics; it's about pleiotropy (genes) & individuality (patients). Denying complexity doesn't make a problem simpler to solve (tell POTUS).
Interesting review on the acquisition of motor skills through (1) innate (2) opportunity-based and (3) systematic tuning processes. The framework is compelling although (2) and (3) may I think be the same process at different time scales. www.nature.com/articles/s41...
Three systems of circuit formation: assembly, updating and tuning - Nature Reviews Neuroscience
In this Perspective, Barabási, Ferreira Castro and Engert challenge the notion that learning and plasticity primarily drive the assembly of neural circuits. They present a tripartite framework for how...
nature.com
New preprint out from the lab, check out thread below!
Esther Klingler@estherkli.bsky.social · last yr.✨ We tend to think of species-specific differences as resulting from the presence of species-specific genes. In our latest work with @djabaudon.bsky.social, we show that building brains is not only about which genes you use, but also about when and where you do. www.biorxiv.org/content/10.1...
The Zona Incerta is really what its name suggests it is. Contains two distinct GBAergic subtypes of neurons involved in seemingly unrelated behaviors: self-grooming for one, and sleep-to-wake transition for the other. www.biorxiv.org/content/10.1... PS: named by swiss anatomist August Forel 🫕🇨🇭
