More evidence that the @asrc-gc.bsky.social is a special place! I’m happy to play a small part in this bigger picture.

Advanced Science Research Center at the CUNY Graduate Center@asrc-gc.bsky.social · 2mo ago

We've reached an extraordinary milestone: Six of our faculty members currently hold NSF Faculty Early Career Development Program awards, one of the nation’s highest honors for early-career scientists. The awards represent more than $4.2 million in research funding. Learn more! https://bit.ly/4frkWxs

It was a true pleasure to catch up multiple eras of RLabbers at "Richardson Fest" this weekend! 20+ of us spoke about the impact Dave & Jane had on us. They are titans of the field of structural biology -- yet intimately focused on the small things in life... Wonderful people all-around!

Pleased to report my lab's new NSF CAREER award to dissect how motions underlie function in natural vs. designed proteins: www.nsf.gov/awardsearch/... I do not take this federal support of our science lightly! @asrc-gc.bsky.social @ccnyscience.bsky.social @cuny.edu = excellent place for this work.

Julia Zhang & I just wrote our lab's second @prereview.bsky.social "pre-review"! It covers a really impressive preprint by Anum Glasgow & crew, just a few blocks north of us. We forgot to use the phrase "tour de force" but that feels applicable. Here's the link: prereview.org/reviews/1971...

Jane Richardson was born #OTD in 1941 + Developed the Richardson (ribbon) diagram to represent proteins' 3D structure (becoming a standard representation for protein structures) + MacArthur Fellow, 1985 + Elected, Nat'l Academy of Sciences, 1991 + President, Biophysical Society, 2012 #WomenInSTEM

New preprint! Entropy drives molecular recognition, yet most structure-based drug design ignores it because it is difficult to measure. X-ray crystallography captures ensembles, not single structures. Can we extract thermodynamically meaningful entropy from them? www.biorxiv.org/content/10.1...

Crystallographic Ensembles Reveal the Structural Basis of Binding Entropy in SARS-CoV2 Macrodomain

Structure-based drug design has traditionally focused on optimizing static, enthalpic interactions between ligands and proteins or on displacing binding site solvent molecules to entropically favor bi...

biorxiv.org

Props to my colleague here at the @asrc-gc.bsky.social , @fravallese.bsky.social , for this wonderful piece about the uniquely strong structural biology community here in NYC. I often feel lucky to be here. Let's keep up the good vibes and forward momentum -- exciting times for struct bio!

Francesca Vallese@fravallese.bsky.social · 9mo ago

Being part of a community has always been essential for me. Finding a vibrant structural biology community in New York shaped my decision to stay in this City. Thank you @natsmb.nature.com for the opportunity to share it on your pages.

Our lab did a JC on this innovative preprint by @mcagiada.bsky.social @sokrypton.org @lindorfflarsen.bsky.social et al. abt predicting AF2 for prot sc flex: www.biorxiv.org/content/10.1... It inspired me to try my hand at a @prereview.bsky.social "preprint review"! prereview.org/reviews/1704...

AF2χ: Predicting protein side-chain rotamer distributions with AlphaFold2

The flexibility of protein side chains is an essential contributor of conformational entropy and affects processes such as folding, stability and molecular interactions. Structure determination experi...

biorxiv.org

I'm pleased to report that my job title has changed! (Except for the 1st 3 letters of the 1st word & the entire 2nd word... 😉) keedylab.org/members/ Grateful that I get to do fun science & train young scientists in an inspiring environment here at @asrc-gc.bsky.social & @ccnyscience.bsky.social!

Summer 2025 #keedylab news round-up: come read about what we did on our summer vacation! keedylab.org/news/ Associated with this website update, I also embedded the lab's Bluesky feed on the website's news page -- thus creating an infinite cycle of delightful lab news links 🔁 💯

We wrote a review article about dynamics, allostery, and function in the PTP enzyme family! Covers experimental and computational approaches, regulatory domains & mechanisms, mutations, ligands, etc. Was hard to fit in ~all the cool advances in recent years!... pmc.ncbi.nlm.nih.gov/articles/PMC...

Orchestrating function: concerted dynamics, allostery, and catalysis in protein tyrosine phosphatases

Protein tyrosine phosphatases (PTPs) are a family of enzymes that play critical roles in intracellular signaling and regulation. PTPs are conformationally dynamic, exhibiting motions of catalytic loop...

pmc.ncbi.nlm.nih.gov

Gift link www.nytimes.com/2025/07/22/s...

Amid Fear of Retaliation, N.S.F. Workers Sign Letter of Dissent

nytimes.com

Happy to say our recent @biorxiv-biophys.bsky.social preprint about 3 unexpected structures of STEP, in its new & improved form, is now published at Proteins! pubmed.ncbi.nlm.nih.gov/40616465/ & doi.org/10.1002/prot...

Three STEPs Forward: A Trio of Unexpected Structures of PTPN5 - PubMed

Protein tyrosine phosphatases (PTPs) play pivotal roles in myriad cellular processes by counteracting protein tyrosine kinases. Striatal-enriched protein tyrosine phosphatase (STEP, PTPN5) regulates s...

pubmed.ncbi.nlm.nih.gov

250 years ago, Americans rejected the rule of a mad king. In two days, we’re taking to the streets again to say NO KINGS. 2,000 peaceful protests are planned in small towns and major cities across the country. Join your community on Saturday for #NoKings Day: www.nokings.org?SQF_SOURCE=i...

New @biorxiv-biophys.bsky.social preprint from the #keedylab! 👀 www.biorxiv.org/content/10.1... How do related proteins perform distinct functions despite sharing a similar structure?...

Mapping allosteric rewiring in related protein structures from collections of crystallographic multiconformer models

How do related proteins with a common fold perform diverse biological functions? Although the average structure may be similar, structural excursions from this average may differ, giving rise to allos...

biorxiv.org

We are looking to hire (yes, even in this economy!) a jr. specialist to train in protein prep/structural biology related to our AVOID-ome work as part of openadmet.org. A great position for someone who is looking to be a tech for a few years before grad or med school. aprecruit.ucsf.edu/JPF05424

Junior/Assistant/Associate/Full Specialist Positions Available

University of California, San Francisco is hiring. Apply now!

aprecruit.ucsf.edu

The third episode of The Tortured Proteins Department is out now! We chatted about grant cancellations, exciting regional meetings and reunions, two fun new preprints, community norms around code release, and the importance of giving kudos. @fraserlab.com

Definitely worth a read and a share...

Rosa Lafer-Sousa@rosalafersousa.bsky.social · last yr.

🚨 This MUST READ essay and call to action spells out, in very clear terms, how the Trump administration could get away with slashing the NIH budget. NIH scientists and Dems in congress need to read and understand it. This is where we win or lose the battle to save the NIH and US science. 🧪 🧠 🧬 🔊

We're hiring for three positions: Asst./Assoc./Prof. of Neuroscience: bit.ly/43ScWzE Research Associate in the MRI Facility: bit.ly/3Ey1ONY Asst./Assoc./Prof. of Photonics: bit.ly/4ijNVkh

Nothing else to say.

Roses are red Violets are blue If you fall in love with your hypothesis You’ll be biased to prove it true 🧪

Are you interested in understanding how the wiggles & jiggles of proteins impact the thermodynamics of ligand binding or catalysis? Well, you are in luck! We are searching for a postdoc to explore these concepts. More details: www.vanderbilt.edu/postdoc/pros... or email stephanie@wankowiczlab.com

Current Opportunities at Vanderbilt

Vanderbilt is committed to providing a meaningful, robust experience for postdocs. Below is a list of currently available postdoctoral opportunities. Postdocs interested in applying for a specific pos...

vanderbilt.edu

"Being a first-generation college student, I’m excited by the idea of training & mentoring other first-generation students & taking on this important responsibility." —Prof. Francesca Vallese. Get to know SBI's new member & her critical area of research. bit.ly/3UYHKcN @thegraduatecenter.bsky.social

Check out our lab's first pub since the great X->Bsky exodus! We used crystallography under different conditions to map new conformational & chemical features of an atypical phosphatase enzyme. Fantastic work by Liliana, Ali, and Blake as well as collabs near (Bishop) & far (Tautz)!

bioRxiv Biophysics@biorxiv-biophys.bsky.social · 2y ago

Three STEPs forward: A trio of unexpected structures of PTPN5 https://www.biorxiv.org/content/10.1101/2024.11.20.624168v1

I'm excited to share our lab's latest @biorxiv-biophys.bsky.social preprint: www.biorxiv.org/content/10.1... This was a really rewarding collaboration between many folks here at the CUNY ASRC and the Farooqi lab at Cambridge, bridging the human genetics of obesity and some cool molecular biophysics!

Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

biorxiv.org

We were incredibly disappointed with the lack of code or executable accompanying the publication of AF3 in @Nature . This contradicts scientific principles of the ability to evaluate, use, and build upon existing work. zenodo.org/records/1117.... Sign to endorse: docs.google.com/forms/d/e/1F...

Earthquake just now in upper Manhattan... Biggest I've ever felt (and I lived in the Bay Area for 5 years)... Reports of the same thing simultaneously in Queens... Everyone here is safe!...

Got back last night from a great visit to Baylor Chemistry & Biochemistry! Thanks to Jonathan Clinger for inviting + hosting -- and was nice to meet @trakselis.bsky.social (& many others not on Bsky)!

Just returned from a wonderful visit to UC Irvine Molecular Biology & Biochemistry! Was nice to be back in the UC system for a day, meet many great folks doing cool science, and get to talk about what we've been up to in the Keedy lab. Special thanks to Melanie Cocco for hosting!

This is the 1957 plasticine model of myoglobin by Kendrew. It is based on X-ray data and shows the polypeptide chain as a large 💩. It is an aesthetic failure but, as the first-ever protein model, it was a huge breakthrough in protein structure 🙂 collection.sciencemuseumgroup.org.uk/objects/co13...