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David Martínez Millán

@dmartmillan.bsky.social

I am an engineer in a biological world.

11 Posts35 Follower69 Folgt
Mònica Sánchez-Guixé@guixe-m.bsky.social · last mo.

1/17 We are very happy to announce our latest work about the genetic origin and evolution of one of the most aggressive pediatric tumors: “Variable latency between the founder genetic event and rhabdoid tumor expansion” www.biorxiv.org/content/10.6.... Follow the thread to know more 👇

Variable latency between the founder genetic event and rhabdoid tumor expansion

Rhabdoid tumors are very aggressive rare pediatric cancers with poor survival affecting very young children. They are characterized by the bi-allelic loss of SMARCB1 or SMARCA4, which is suspected to ...

biorxiv.org

Kurianlab@kurianlab.bsky.social · last mo.

Ribo-Tweezer by @mbarnalab.bsky.social, a modular platform to deplete proteins from mature ribosomes . www.cell.com/molecular-ce... @jakub-zeman.bsky.social and I wrote a Preview on why this helps to turn ribosome heterogeneity into an experimentally testable paradigm www.cell.com/molecular-ce...

Tweezing apart ribosome heterogeneity

In this issue of Molecular Cell, Chen et al. introduce Ribo-Tweezer: a modular platform for conditionally and selectively depleting proteins from mature ribosomes, enabling direct tests of their ribos...

cell.com

Raquel Blanco@raquelbmi.bsky.social · 10mo ago

Very happy to share that our paper on the influence of biological sex and smoking in the clonal landscape of the normal human bladder is out today in Nature. Kudos to all the authors and especially to @ferriol.bsky.social for coming along with me during this project's journey! 🧵Summary following ⬇️

Nuria Lopez-Bigas@nlbigas.bsky.social · 10mo ago

🚨 New paper alert! Sex and smoking bias in the selection of somatic mutations in human bladder www.nature.com/articles/s41... by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)

Barcelona Biomedical Genomics Lab@bbglab.bsky.social · 2y ago

As we are quite new in that network, we take the chance to share our research achievements of the last year. Here you can follow a short 🧵of our latest publications: 1️⃣ www.nature.com/articles/s41...

Five latent factors underlie response to immunotherapy - Nature Genetics

Analysis of human tumor datasets shows that all features that appear significantly associated with immunotherapy response and survival may be collapsed into five latent factors: tumor mutation burden, T cell effective infiltration, TGF-β activity in the microenvironment, prior treatment and tumor proliferative potential.

nature.com

Javier Santoyo@jsantoyo.bsky.social · 2y ago

OpenVariant: a toolkit to parse and operate multiple input file formats. #Genomics #VariantFormats #InputFileFormats #Bioinformatics 🧬 🖥️ Github; github.com/bbglab/openv... academic.oup.com/bioinformati...

OpenVariant: a toolkit to parse and operate multiple input file formats

AbstractSummary. Advances in high-throughput DNA sequencing technologies and decreasing costs have fueled the identification of small genetic variants (suc

academic.oup.com

David Martínez Millán@dmartmillan.bsky.social · 2y ago

🎉 I'm thrilled to announce that OpenVariant is finally published! A comprehensive toolkit to facilitate reading, parsing and refinement of diverse input file formats in a customizable structure, all within a single process. @bbglab.bsky.social at @irbbarcelona.bsky.social doi.org/10.1093/bioi...

OpenVariant: a toolkit to parse and operate multiple input file formats

AbstractSummary. Advances in high-throughput DNA sequencing technologies and decreasing costs have fueled the identification of small genetic variants (suc

academic.oup.com