🧬NEW PAPER🧬 To what extent is cancer development deterministic? Does the germline genome affect that predictability? Find out in our #StrainDifferences paper @nature.com "Genetic background sets the trajectory of experimental cancer evolution" www.nature.com/articles/s41... 🧵[1/14]

Genetic background sets the trajectory of experimental cancer evolution - Nature

Experimentally replaying tumour evolution in divergent mouse strains reveals the importance of interactions between genetic ancestry and acquired cancer-driving mutations in shaping the earliest stage...

nature.com

1/17 We are very happy to announce our latest work about the genetic origin and evolution of one of the most aggressive pediatric tumors: “Variable latency between the founder genetic event and rhabdoid tumor expansion” www.biorxiv.org/content/10.6.... Follow the thread to know more 👇

Variable latency between the founder genetic event and rhabdoid tumor expansion

Rhabdoid tumors are very aggressive rare pediatric cancers with poor survival affecting very young children. They are characterized by the bi-allelic loss of SMARCB1 or SMARCA4, which is suspected to ...

biorxiv.org

I would like to announce that I have recently started my own research group, the Pediatric Cancer Genomics Laboratory, at Institut de Recerca Sant Joan de Déu (IRSJD) - Fundació de Recerca Sant Joan de Déu.

Excited to share our latest work in Nature. Applying single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune B cells, suggesting that somatic mutations may be key to autoimmunity [1/n] rdcu.be/fdqbr

Tumor promotion through the lens of evolution This review grew out of many long conversations, shared ideas, and lively discussions It has been a real pleasure to think together with Allan, Paul, Eve, and Abel about how tumours develop and how carcinogens shape cancer risk rdcu.be/fdC2J

Tumour promotion through the lens of evolution

Nature - This Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable...

rdcu.be

Interested in a PhD Fellowship in our Lab? Check out the new #IRBBarcelona call:

IRB Barcelona@irbbarcelona.org · 9mo ago

Looking for your next career move in science? We are #hiring! Discover our latest job and #PhD opportunities! #Jobs ➡️ bit.ly/irbjobs PhD General call ➡️ https://bit.ly/3LtzIXi PhD IRB DRIVE call ➡️ https://bit.ly/4hODx5B #IRBJobs #ScienceJobs #Jobs #JobOffer #JobOffers #OncoSky #AcademicSky 🧪

Our team at #EMBLCanGen in Heidelberg! Raquel Blanco gave a brilliant talk, and we had great poster presentations from Elisabet Figuerola, Olivia Dove, Ferran Muiños, Rocio Chamorro, and Axel Rosendahl. 👏 Thanks to @events.embl.org for organizing such a high-quality event in Cancer Genomics!

Delighted and honored to have hosted the 3rd PROMINENT Retreat in Barcelona. The @cancergrand.bsky.social project led by Allan Balmain, Paul Brennan and Nuria Lopez-Bigas, is progressing thanks to the excellent science being performed by all the teams. Great meeting and best participants!

🚨 New paper alert! Sex and smoking bias in the selection of somatic mutations in human bladder www.nature.com/articles/s41... by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)

Sex and smoking bias in the selection of somatic mutations in human bladder - Nature

Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.

nature.com

🧪 Out in @nature.com:  Smoking and biological sex shape healthy bladder tissue evolution, offering clues to #cancer risk.  ✍️ #IRBBarcelona & University of Washington 📌 DOI: 10.1038/s41586-025-09521-x Video credits: 3CatInfo, Som3cat #IRBScience #CancerResearch #BladderCancer @bbglab.bsky.social

Scientists have used low-error genome-sequencing methods in normal tissues from large cohorts of individuals to scan for mutations that set the stage for cancer go.nature.com/42vakWS

Ultra-sensitive DNA sequencing maps mutations that precede cancer

Scientists have used low-error genome-sequencing methods in normal tissues from large cohorts of individuals to scan for mutations that set the stage for cancer.

go.nature.com

New research from team PROMINENT (@nlbigas.bsky.social), published in @nature.com, uncovers clues why men face a higher risk of bladder cancer and reveals that tobacco smoke acts as a promoter, not an initiator, in bladder cancer development. Read more: www.cancergrandchallenges.org/news/early-c...

🧪 Out in @nature.com: Smoking and biological sex shape healthy bladder tissue evolution, offering clues to #cancer risk. ✍️ #IRBBarcelona & University of Washington ➡️ bit.ly/42wcIN5 📌 DOI: 10.1038/s41586-025-09521-x #IRBScience #CancerResearch #BladderCancer @bbglab.bsky.social 🧵👇

Very happy to share that our paper on the influence of biological sex and smoking in the clonal landscape of the normal human bladder is out today in Nature. Kudos to all the authors and especially to @ferriol.bsky.social for coming along with me during this project's journey! 🧵Summary following ⬇️

Nuria Lopez-Bigas@nlbigas.bsky.social · 10mo ago

🚨 New paper alert! Sex and smoking bias in the selection of somatic mutations in human bladder www.nature.com/articles/s41... by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)

New paper from our lab - ‪@bbglab.bsky.social‬. Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection academic.oup.com/nar/article/... Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel

Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection

Abstract. Identifying the genes capable of driving tumorigenesis in different tissues is one of the central goals of cancer genomics. Computational methods

academic.oup.com

To better treat cancer, we need to understand its underlying biology. Despite decades of research, some fundamental questions remain unanswered. One is why certain key tumor suppressor or oncogenes lead to cancer predominantly in single tissue: e.g. Rb in the retina, or APC in the colon 1/n 🧪

Back after a few days in Lisbon for the annual #EACR2025 conference! Inspiring and great science. Glad for the opportunity to present our work, coming home with a bunch of new ideas! @bbglab.bsky.social @ferriol.bsky.social

Our colleagues Olivia Dove, Raquel Blanco and Ferriol Calvet are attending the #EACR2025. They are sharing their research results with their respective posters and are for sure learning a lot in an excellent Congress with an outstanding list of speakers. @ferriol.bsky.social @raquelbmi.bsky.social

Today is the start of #EACR2025! We’re excited to welcome a record number of participants from 66 countries to our Annual Congress here in Lisbon. Find the programme at 2025.eacr.org and don’t forget to use the hashtag!

An analysis in Nature Medicine confirms that the microbiome can be a clinical target for colorectal cancer screening and characterizes it as a biomarker for colorectal cancer progression. go.nature.com/3Hrux8m #medsky 🧪 🧬

🌟 Are you passionate about computational immuno-oncology research with real clinical impact? 🌟 Our group is looking for a motivated Bioinformatics Scientist for single-cell transcriptomics🧬💻 See offer here 👉 jobs.vhio.net/en/jobs/6016... #Bioinformatics #SingleCellRNA #Immunogenomics

Kudos to @raquelbmi.bsky.social and @ferriol.bsky.social, first authors of the study, for the insane amount of good work put into this.

Hello world! Kicking off my first post with some exciting news 📣 Our study on tobacco smoke-induced mutagenesis in head & neck cancer (HNC) is out today in @naturegenet.bsky.social! rdcu.be/efNiH 🧬🔥 We uncover the multiple ways tobacco and alcohol drive HNC development. A short thread 🧵⬇️

The complexity of tobacco smoke-induced mutagenesis in head and neck cancer

Nature Genetics - Whole-genome sequencing and mutational signature analysis of 265 head and neck cancer samples collected from eight different countries provide insight into the vital contribution...

rdcu.be

Join us in beautiful Barcelona!!

Barcelona Biomedical Genomics Lab@bbglab.bsky.social · 2y ago

We are searching for a Research Assistant/Bioinformatician at @irbbarcelona.org bbglab.irbbarcelona.org/2024/12/job-... #IRBJobs

🎉 I'm thrilled to announce that OpenVariant is finally published! A comprehensive toolkit to facilitate reading, parsing and refinement of diverse input file formats in a customizable structure, all within a single process. @bbglab.bsky.social at @irbbarcelona.bsky.social doi.org/10.1093/bioi...

OpenVariant: a toolkit to parse and operate multiple input file formats

AbstractSummary. Advances in high-throughput DNA sequencing technologies and decreasing costs have fueled the identification of small genetic variants (suc

academic.oup.com

Hi Bluesky! Nice to see the scientific community growing here 🤗