Daniela Belloni et al. developed a 3D tissue-like lymph node model recapitulating the malignant microenvironment of chronic lymphocytic leukaemia, enabling investigation of disease evolution and therapeutic response driven by microenvironmental interactions. journals.biologists.com/dmm/article/...

Mathematical modelling is not simply data fitting. Done well, it is a tool for hypothesis testing that proceeds by successively excluding incorrect models rather than by claiming one well-fitting model to be true. Read the Perspective by Philip Greulich journals.biologists.com/dmm/article/...

There's still time to apply to present a poster at our meeting on Innovative Preclinical Models for Pediatric Cancer Research. Don't miss the chance to be part of this exciting meeting. Submit your poster abstract by 31 August 2026 bit.ly/46r84Ca

This Review by Bijay Guragain and colleagues examines recent developments in cardiomyocyte-based therapies for heart disease, with a particular focus on electrical coupling between graft and host tissue and the risk of graft-associated arrhythmias. journals.biologists.com/dmm/article/...

*** Call for papers *** Submit your latest #paediatric #geneticdiseases paper to be included in our next special issue. We welcome Research Articles and Resources & Methods articles. Find out more today 👇️ tinyurl.com/36fdfy4d

At a glance article by Shan Tu et al.: In vitro and in vivo models for androgenetic alopecia drug development journals.biologists.com/dmm/article/...

The findings in this Research Article from Irena Rysankova et al. suggest metabolic shifts and putative genotoxic events in the pluripotent stem cell state of the TgHD model and point to early effect of the HD mutation. journals.biologists.com/dmm/article/...

In this Research Article, Allison Boboltz et al. share how myeloperoxidase, was found to directly inhibit airway clearance function and may represent a new therapeutic target for cystic fibrosis. journals.biologists.com/dmm/article/...

This Perspective by Masashi Okamoto and Takanori Takebe proposes mesoscale maladaptation as a framework for interrogating concurrent failures across multi-tissue organoid interfaces that create disease-relevant, synergistic pathology across lineages. journals.biologists.com/dmm/article/...

#preprint #Prelights post on how adiposomes offer a solution to the challenges faced by hydrophobic drug delivery. prelights.biologists.com/highlights/n...

Nature-Inspired Nanoparticle Adiposomes Enable Targeted Delivery of Hydrophobic Drug for Anti-Cancer Treatment - preLights

An innovative solution to nanoparticle drug delivery

prelights.biologists.com

In this Research Article, Nicole West et al. show, for the first time, that Leucettinib-21, a pharmacological inhibitor of DYRK1A, decreases DYRK1A kinase activity in a human induced pluripotent stem cell-derived neural cell culture model of Down syndrome. journals.biologists.com/dmm/article/...

Gut instinct drives discovery: an interview with @hansclevers.bsky.social journals.biologists.com/dmm/article/...

In this Editorial, the Guest Editors of the new special issue discuss how in vitro models further our understanding of the mechanisms of disease, accelerating drug development and enabling customised approaches to treatment. journals.biologists.com/dmm/article/...

Our latest special issue on #invitro models of human disease is complete! Read all articles for free: tinyurl.com/2re3d5wh Cover image: A human induced pluripotent stem cell-derived inner ear organoid following ototoxic injury and recovery. See article by Lucassen et al.

*** Call for papers *** Submit your latest #paediatric #geneticdiseases paper to be included in our next special issue. We welcome Research Articles and Resources & Methods articles. Find out more today 👇️ tinyurl.com/36fdfy4d

Last chance to secure early-bird registration and submit an abstract for #DMM2026cancer. Deadline: 17 July Register now for your chance to be selected for a short talk. We hope you can join us. bit.ly/46r84Ca #PediatricCancer #Oncology

Looking forward to @thebacr.bsky.social #Tumour Microenvironment and 3D #Cancer Modelling Workshop starting today! Come visit our table to chat to Senior Editor @kirstyhooper.bsky.social about the cutting-edge cancer research we publish:

Cancer | Disease Models & Mechanisms | The Company of Biologists

The complexity of cancer has prompted scientists worldwide to employ a breadth of approaches to investigate the mechanisms underlying the disease. Recent a

journals.biologists.com

Final chance to register for the @fusionconf.bsky.social 4th Metabolism in Health & Disease conference, 10 - 13 October in Portugal. 📆Registration closes 13 July 2026 📌Poster slots available Click here for the programme, abstract & grant opportunities available: bit.ly/4cQeQW6

Completely unable to resist anything that mentions #cats. Inhibition of VP2-mediated entry: a potential antiviral strategy to treat or prevent calicivirus disease prelights.biologists.com/highlights/i...

Inhibition of VP2-mediated entry: a potential antiviral strategy to treat or prevent calicivirus disease - preLights

Cats: the ultimate pets and scientific heroes. Researchers are studying feline viruses to identify innovative solutions to prevent human infections

prelights.biologists.com

There are so many fun ways to approach research dissemination! Tried the @prelights.bsky.social spotLight video format to share our latest published work on how ZIC2 shapes early neural development! Total YouTuber vibes: and I kinda' loved it, tbh. 🤳🔬👇 youtu.be/V_yMoWMkZCM

spotLights Ep 21: María on how ZIC2 shapes neural development #neuroscience #science #biology

YouTube video by The Company of Biologists

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Have you seen Cancer Conference Hub - @helloeacr.bsky.social calendar of cancer research conferences? You can add your event too. See more at bit.ly/4u1L6LP #CancerResearch

Looking forward to the @cclguk.bsky.social symposium on the developmental origins of paediatric cancers at the @crick.ac.uk on Monday! As @dmmjournal.bsky.social are sponsoring, we will have a table, so come chat! www.cclg.org.uk/information-...

Man Waving Hello in Deer Shirt

ALT: Man Waving Hello in Deer Shirt

static.klipy.com

Claudia Kleinman @claudiakleinman.bsky.social is speaking on 'From robust cell fates to plastic states: Lineage constraints in pedi brain tumors' at our Journal Meeting in October #DMM2026cancer #pediatriccancer Register to attend: biologists.com/meetings/dmm... Early-bird deadline: 19 June 2026

In this new paper Hiramuki, Jones & co show that cre-reporter mouse lines expressing human DUX4 regulatory elements can be used as discovery tools for developmental processes and mechanisms underlying #FSHD (Facioscapulohumeral muscular dystrophy) doi.org/10.1242/dmm....

Hats off to the winner of our 2025 Outstanding Paper Prize for Resources & Methods articles - Victoria Ektnitphong @ UT Southwestern Medical Center Ektnitphong and colleagues describe a humanized lung-on-a-chip model that offers new insights into TB.

An alveolus lung-on-a-chip model of Mycobacterium fortuitum lung infection

Summary: A humanized lung-on-a-chip model reveals early immune responses to Mycobacterium fortuitum infection, offering new insights into non-tuberculous mycobacteria pathogenesis relevant for drug…

doi.org

Lena Kutscher @lenakutscher.bsky.social is speaking on '2D and 3D models of embryonal brain tumor initiation' at our Journal Meeting this October #DMM2026cancer #pediatriccancer Register to attend: biologists.com/meetings/dmm... Early-bird deadline: 19 June 2026

In this new paper Kolesnikova, Ellederova & co generate a knock-in minipig model with an expanded HTT allele to recapitulate early molecular characteristics of #Huntingtonsdisease, providing a valuable platform for evaluating emerging therpaies 📰 doi.org/10.1242/dmm....

🏆 Congratulations to the DMM 2025 Outstanding Paper Prize winner for Research Articles: Joshua D. Ginzel @Duke University School of Medicine. Read our Editorial to learn more about the winner & their research. doi.org/10.1242/dmm....

Weekend read: head to @prelights.bsky.social website and read a preprint about the mechanisms underlying sex-specific vulnerabilities to prenatal stress, chosen by Alice Gennevois, Ariane Delisle, uMontreal Neuro preLighters. Prelight: bit.ly/4wC0jVs Preprint: doi.org/10.64898/202...

Congratulations to DMM Editorial Advisory Board member Paul Riley (dpag.ox.ac.uk/research/ril...) on being elected to the Fellowship of the Royal Society.