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María Mariner

@mariamafau.bsky.social

Postdoctoral researcher at @radaiglesiaslab.bsky.social | Developmental genomics | preLighter (The Company of Biologists) | Artistic & Creative | Passionate about visual storytelling and design

30 Posts345 Follower721 Folgt
James Briscoe@jamesbriscoe.bsky.social · 2mo ago

Our latest: Minimal essential requirements for neural tube self-organisation How does a single cell give rise to a tissue with the right cell types in the right proportions? We deconstruct and rebuild a self-organising tissue from first principles A thread🧵 www.biorxiv.org/content/10.6...

Minimal essential requirements for neural tube self-organisation

The reliable generation of diverse cell types in precise proportions is essential for the formation of functional tissues during embryonic development. Three-dimensional organoid models derived from p...

biorxiv.org

Tjian + Darzacq Lab, UC Berkeley@tjiandarzacq.bsky.social · 2mo ago

Out now in Science! Our study challenges long-standing assumptions about transcription factor specificity in eukaryotes. Novel single-molecule measurements of TF behavior in living cells reveal an independence of locus-specific binding from DNA sequence recognition.🧵 www.science.org/doi/10.1126/...

Unstructured transcription factor interactions enable emergent specificity

How intrinsically disordered regions (IDRs) shape chromatin binding and nuclear organization of transcription factors (TFs) remains unclear. We used proximity-assisted photoactivation (PAPA), a single...

science.org

María Mariner@mariamafau.bsky.social · 3mo ago

🚨Happy to share a new PreLight covering the latest #preprint by the Meissner lab (@molgen.mpg.de) on acute SUZ12 degradation during TLS formation. A work brilliantly executed by @dannimklee.bsky.social et al. Get to know more about him and his work here ⤵️ prelights.biologists.com/highlights/t...

Temporal degradation of PRC2 uncovers specific developmental dependencies - preLights

Pairing acute SUZ12 degradation + simplified embryoids, Ming-Kang Lee et al. pinpoint time-dependent sensitivities to PRC2 loss. A meticulous experimental approach applicable to the functional stage-s...

prelights.biologists.com

Craig Kaplan@triggerloop.bsky.social · 6mo ago

This is a fascinating paper that reveals defined and clear mechanism for a phenomenon that for some seemed unbelievable- the up regulation of genes paralogous to those with specific types of inactivating mutations. This is called transcriptional adaptation 1/ www.science.org/doi/10.1126/...

Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation

Transcriptional adaptation (TA) is a genetic robustness mechanism through which mutant messenger RNA (mRNA) decay induces sequence-dependent up-regulation of so-called adapting genes. How cytoplasmica...

science.org

MadScientist@mads100tist.bsky.social · 6mo ago

This graph basically shows that the MSCA are, as of now, useless unless the EU governance does something about it 🧪

A graph titled "MSCA Postdoctoral Fellowships: section EF-LIF". The graph shows the scores between 70 and 100 over the years 2022, 2023, 2024 and 2025. The years 22, 23 and 24 show a relatively flat normal distribution that peaks at around 90ish and drops at both ends, more dramatically at 95+. The year 25, however, is very different: significant drop at the ends with a dramatic increase at ~95 (going from around 25 to 60ish %)
Natalie Schaworonkow@nschawor.bsky.social · 6mo ago

the cutoff scores for #MSCA postdoc fellowships are very high this year. has the score distribution shifted compared to previous years? I made a plot with scores from past years. if scores are at ceiling level, the process becomes essentially a lottery, because minor issues can lead to deductions.

Surfin' NuRD@surfinnurd.bsky.social · 6mo ago

Final version of our paper now published. elifesciences.org/articles/109... Take homes: CHD4/NuRD directly limits transcription factor residence times. At active enhancers this keeps them working efficiently. At inactive enhancers it prevents TFs from getting a foothold and causing activation. 1/n

The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements

CHD4 directly limits transcription factor binding to chromatin, which prevents activation of silent or cryptic enhancers but facilitates activity of active enhancers.

elifesciences.org

FragileNucleosome@fnucleosome.bsky.social · 8mo ago

Do you have an exciting new chromatin/transcription story that you'd like to share with the #FN community? Fill out this form to be considered for a talk in our Jan-June 2026 schedule! forms.gle/TBi38UgYxPAB... Please repost and share!

Application to speak in the Fragile Nucleosome series

Thank you for your interest in our seminar series! We use a variety of different session formats but, in general, trainees can plan for a ~15 min talk + 5min Q/A and PIs can plan for a ~25min talk +...

forms.gle

Rada-Iglesias Lab@radaiglesiaslab.bsky.social · 9mo ago

OFERTA DE EMPLEO (por favor difundir): Ofrecemos un contrato predoctoral de 4 años asociado a nuestro proyecto PID2024-157249OB-I00. El objetivo del proyecto es evaluar un nuevo mecanismo patológico según el cual la competición entre promotores puede llegar a ocasionar enfermedades congénitas 👇

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