Inflammatory cytokines can hijack mTORC1 in #cancer cells, resulting in amino acid competition with #CD8+ cells and starved #immunity. We discuss findings from Xiang et al in our News&Views article for @natcellbio.nature.com www.nature.com/articles/s41... Full access: rdcu.be/fh2a6

Inflammation starves antitumour immunity - Nature Cell Biology

When cells sense amino acids, they activate a kinase complex known as mTORC1 in a process that can regulate cancer metabolism and growth. Work now shows that in nutrient-limiting conditions, inflammat...

nature.com

Urolithin A supplementation for 28 days shifted immune cell profiles in older adults toward a more youthful, less exhausted state and enhanced mitochondrial fatty acid oxidation capacity. doi.org/g99kft

Urolithin A nudges aging immune cells toward a youthful profile in 28 days

An international research team focused on aging reports that urolithin A at 1,000 mg per day shifted human immune profiles toward a more naive-like, less exhausted CD8+ state and increased fatty acid oxidation capacity, with additional functional gains.

medicalxpress.com

In a RCT, Urolithin-A boosted CD8⁺ T cells and improved immune metabolism, hinting at a new way to slow age-related immune system decline and inflammaging. buff.ly/qaGyGF0 Urolithin A works by inducing mitophagy (clearance of damaged mitochondria). #medsky #aging

Excited to share our new study in @nataging.nature.com !🎉 www.nature.com/articles/s43... We show that Urolithin A, a pomegranate-derived gut metabolite, counteracts key signs of immune #aging in a phase I trial! #immunology #aging @loewe-fci.bsky.social @goetheuni.bsky.social #immunosky

Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial - Nature Aging

Immune aging fosters multimorbidity and compromises control of infection and cancer. In a phase 1 randomized controlled trial in middle-aged adults, Denk and colleagues administer the mitophagy induce...

nature.com

Happy to repost the study in @cp-immunity.bsky.social now with the cover illustrating the Janus-faced role of IL-17RA in #colorectalcancer. More information below by @domdenkmd.bsky.social or the latest issue of Immunity: www.cell.com/immunity/cur... #DarmkrebsmonatMärz @proloewe.bsky.social

Dominic Denk@domdenkmd.bsky.social · last yr.

Finally announcing our new study in @cp-immunity.bsky.social! We show that IL-17RA fulfills dual tumor suppressor function in late-stage colorectal cancer (CRC)! #immunosky #cancer #immunology @loewe-fci.bsky.social @cellpress.bsky.social @goetheuni.bsky.social Read here🧵👇: tinylink.net/OS41F

Online now: Online now: IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis

IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis

Members of the interleukin-17 family are associated with tumor progression in various settings. Denk et al. find that, in colorectal cancer, IL-17RA switches from tumor promotion during early tumorigenesis to tumor suppression during tumor invasion and…

dlvr.it

Fresh from @cp-immunity.bsky.social "A Surprising Shift from Foe to Friend: Researchers discover dual role of inflammatory signaling in colorectal cancer" 👏Congratulations @domdenkmd.bsky.social and all coauthors!! 🎉 Read the full article here: www.cell.com/immunity/ful... @proloewe.bsky.social

Dominic Denk@domdenkmd.bsky.social · last yr.

Finally announcing our new study in @cp-immunity.bsky.social! We show that IL-17RA fulfills dual tumor suppressor function in late-stage colorectal cancer (CRC)! #immunosky #cancer #immunology @loewe-fci.bsky.social @cellpress.bsky.social @goetheuni.bsky.social Read here🧵👇: tinylink.net/OS41F

Finally announcing our new study in @cp-immunity.bsky.social! We show that IL-17RA fulfills dual tumor suppressor function in late-stage colorectal cancer (CRC)! #immunosky #cancer #immunology @loewe-fci.bsky.social @cellpress.bsky.social @goetheuni.bsky.social Read here🧵👇: tinylink.net/OS41F

IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis

Members of the interleukin-17 family are associated with tumor progression in various settings. Denk et al. find that, in colorectal cancer, IL-17RA switches from tumor promotion during early tumorige...

cell.com

Good morning, all. A rich and diverse list of curated papers in #cancermetabolism and #mitochondrialbiology is ready for you! Don't miss it! Find it here: biomed.news/bims-camemi/... @biomednews.bsky.social "In the midst of winter, I found there was, within me, an invincible summer."-Albert Camus

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media.tenor.com

Good Sunday, all! A short but rich summary of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #dontstopreading “The Eyes See Only What The Mind Is Prepared To Comprehend.” ― Henri Bergson

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