I hear so much about the growing power of predictive biology, especially in drug discovery and "co-folding". I want to see people put their GPU budget where their mouth is!
Doug Kojetin
@dougkojetin.bsky.social
Structural biology, biophysics, biochemistry, molecular and cellular pharmacology | nuclear receptors | NMR | Vanderbilt University, School of Medicine Basic Sciences, Department of Biochemistry | kojetinlab.org
Come be my colleague at UCSF! Our department BTS (like the K-pop band, but aka Bioengineering and Therapeutic Sciences) is searching for TWO new faculty members. Links, timeline, and why two searches in this thread 🧵
Confirmation of the new triage line at 65-70% of proposals. Introduction of a new “competitive but ND” class to permit exception pay pickups.
Drug Monkey@drugmonkey.bsky.social · 11mo agoHere we go. Its ALL #NIHGrant applications. Dec 8 is the new deadline. And a one page prelim data update will be accepted for all May Council submissions. grants.nih.gov/grants/guide...
Happy to serve! 🧲 #NMR
National MagLab@nationalmaglab.bsky.social · 12mo agoThank you to the members of the MagLab's User Committee who were in town this week to provide feedback to lab leadership on our proposal process, capabilities, performance, and key initiatives to ensure they best align with user needs.
TTPD #7 with @fraserlab.com. We chatted about the recent meetings, news, preprint engagement notifications, and the point of rotations. wankowiczlab.com/2025/09/27/T... Spotify: open.spotify.com/episode/0JCB...
The Tortured Proteins Department, Episode 7
This is the official web page for the Stephanie Wankowicz Lab at Vanderbilt University.
wankowiczlab.com
Since there is some discussion that NIH institutes should not simply use paylines to determine which grants to fund, I thought I would share some old data. These are plots of funding probability fas a function of percentile score for 9 institutes. 1/7
So that adds up to 340 new R01 that were not funded in this past week alone, due to the multi-year funding mandate. sorry, "strong suggestion".
I am all for journal caps but $2000 is too low. As @peiferlabunc.bsky.social said, it costs $ to run a journal.
Mark Peifer (He, him)@peiferlabunc.bsky.social · last yr.NIH is considering changes in supporting publication costs--some ideas are quite radical and would endanger our ability to publish at all. I don't love the cots from the big for-profits but it does cost$ to run a journal. Please repost. Comment at: osp.od.nih.gov/comment-form....
Today #NIH leadership were told no funds can go out for research project grants, R&D contracts or training grants. We have just a couple weeks to get funds out the door before Russel Vought attempts a #PocketRescission on Aug 15. Even if this ends up being temporary, it’s time we don’t have.
I wrote a commentary for the Sun-Sentinel about training as a scientist in South Florida and the role/importance of federal funding for biomedical research. While focused on Florida, it applies broadly. Gift link, feel free to share: www.sun-sentinel.com/2025/06/14/d...
Don’t let the light of science dim in the Sunshine State | Opinion
Seth Tomchik received his undergraduate and graduate training in South Florida and went on to run a Scripps Florida lab before moving to the University of Iowa. Federal funding for scientific resea…
sun-sentinel.com
In France, we are very grateful for the support of @cnrs.fr and #Infranalytics that allows us to access the 1.2 GHz spectrometer in Lille for free (upon selection of proposals of course).
Magnetic Resonance News@nmr900.bsky.social · last yr.National Gateway Ultrahigh Field NMR Center gateway-nmr.osu.edu #NMRchat #NMR 🧲 External Academic: $25/hr Industry: $200/hr
Anyone have a lead on replacement syringes for Malvern VP-ITC instruments? They no longer sell them, and they want me to upgrade to the PEAQ system. Unfortunately, we have a PEAQ-ITC, and it doesn't work with the concentrations needed for nanoparticle experiments. #chemsky #biophysics #ITC
Basic science saves lives and fuels the economy, which is why I’m advocating for: ➡️NIH & NSF to spend FY25 funds ➡️$51.3B for NIH, $9.9B in FY26 ➡️Restoration of many canceled NIH & NSF grants Act now. Contact your lawmakers today: asbmb.quorum.us/campaign/123.... #ScienceServesUsAll #ASBMBAdvocates
Urge Congress to re-establish the U.S. as the Leader in Innovation
American Society For Biochemistry And Molecular Biology
asbmb.quorum.us
No-cost extensions of NIH grants are no longer automatically approved drugmonkey.wordpress.com/2025/05/09/n...
No-cost extensions of NIH grants are no longer automatically approved
The no-cost extension (NCE) allows the recipient of a NIH grant to continue to spend on the project after the original award interval has expired. This NIH website explains the way NCE used to work…
drugmonkey.wordpress.com
Heavy water isn’t water. That goes for protein NMR experiments and for a lot else besides:
Heavy Water in Your NMR Experiments, And Elsewhere
science.org
Here @cameronicohen.bsky.social dives into the new findings from the @dougkojetin.bsky.social & the John Yang labs ... "From activation to repression: decoding the impact of PPARγ ligands on ligand-binding domain conformation" bit.ly/43P7xJG @vubasicsciences.bsky.social @vanderbilt.edu
Budget released today: 40% cut to NIH 50% cut to NSF If enacted, this will destroy academic research in the United States. It will also have a major trickle down effect on the entire academic ecosystem
Burnette lab graduate student, Zach Sanchez, won the Steve Hann Outstanding Graduate Student Award! He then gave a fun talk on blebbisomes! You can read about his work here: nature.com/articles/s41... @vubasicsciences.bsky.social
TV watching recommendations The lead story on 60 Minutes tonight is about NIH and concerns about damage done and continuing during the current administration. 1/2
Looking forward to digging into this new @natchembio.nature.com review article by my colleague @stephanieaw.bsky.social (and @fraserlab.com)! @vanderbilt.edu @vumedicine.bsky.social @vanderbiltcsb.bsky.social pubmed.ncbi.nlm.nih.gov/40275100/
Advances in uncovering the mechanisms of macromolecular conformational entropy - PubMed
During protein folding, proteins transition from a disordered polymer into a globular structure, markedly decreasing their conformational degrees of freedom, leading to a substantial reduction in entr...
pubmed.ncbi.nlm.nih.gov
Next Tues (4/29) at **4:30PM** ET, we will have @ginaelnesr.bsky.social @hkws.bsky.social present "Learning millisecond protein dynamics from what is missing in NMR spectra" Paper: biorxiv.org/content/10.1... Sign up on our website for zoom links!
Learning millisecond protein dynamics from what is missing in NMR spectra
Many proteins’ biological functions rely on interconversions between multiple conformations occurring at micro-to millisecond (µs-ms) timescales. A lack of standardized, large-scale experimental data ...
biorxiv.org
Some new language appeared in the HHS Grants Policy Statement last week. It doesn't apply to NIH grants (yet) 1/n
a man is sitting at a table in a kitchen with the words ermah-gerd written on the screen behind him .
ALT: a man is sitting at a table in a kitchen with the words ermah-gerd written on the screen behind him .
media.tenor.com
In science, we don’t give negative data nearly enough love. Showing with genetic precision that CGRP and Substance P aren’t needed for different kinds of acute and chronic pain? That’s huge.
Alex Chesler@alexchesler.bsky.social · 2y ago
Peer networks are so important. We built @nrimpact.bsky.social for this reason, and while we did not anticipate *waves hands wildly* when we put the group together in 2019, the 46 faculty in our group lean on each other in times of personal and professional challenges. www.nrimpact.com
NR IMPACT
nrimpact.com
Tori Smith Ekstrand@toriekstrand.bsky.social · 2y agoIf you are professor and you are feeling alone, it really doesn't have to be that way. It really doesn't. Send that msg to a colleague, join a faculty group, join @aaup.bsky.social. We are used to a lot of time alone with our keyboards, but this isn't one of those moments.
Congrats to Kelly O’Rourke, the Department of Biochemistry's Trainee of the Month! 👏🏾👏👏🏻👏🏽 Kelly works in the lab of @dougkojetin.bsky.social and her advice for other students Make self-care a priority. "When I have balance in other areas of my life, I feel more productive and motivated in the lab."
The Tortured Proteins Department Esp. 2 with @fraserlab.bsky.social is out! In addition to bantering about the craziness of the times, we chat about some recent exciting preprints (see links below). open.spotify.com/show/10PHVou...
Episode 2: Cool Science Among Continued Uncertainty by The Tortured Proteins Department
We chatted about the continued chaos of science infrastructure and dived into some cool science from recent meetings Jaime and Stephanie attended. We introduce two new segments: preprints and how to d...
creators.spotify.com