Our new preprint deeply profiling human antibody-secreting cells (ASCs) is out! We used single-cell multi-omics to discover 5 subsets and relate their surface protein profiles gene expression profiles and epigenetic regulatory programs. And that's just the start! www.biorxiv.org/content/10.6...

Multi-omic profiling of human antibody-secreting cells reveals diverse subsets sustain durable humoral immunity https://www.biorxiv.org/content/10.64898/2026.04.13.717827v1

A study from the lab of @evnewell.bsky.social looks at the immune response to multiple myeloma. It turned out the most interesting thing was what they didn’t find: T cells that had already recognized and tried to fight off tumor cells. Read more: pubmed.ncbi.nlm.nih.gov/40163891/

I'm happy to share our new publication exploring T cell responses in patients with newly diagnosed multiple myeloma. Using single-cell multi-omics, we found no evidence of T cell exhaustion nor a productive clonal T cell response, suggesting myeloma uses an alternative immune evasion strategy.

Hallmarks of T-cell exhaustion and antigen experience are absent in multiple myeloma from diagnosis to maintenance therapy

Key PointsEvidence of tumor-specific and/or terminally exhausted CD8+ T cells is absent in a longitudinally analyzed cohort of patients with NDMM.

doi.org

Come hear about human antibody-secreting cell multi-omic profiles and functional characteristics at my talk in the Lymphocyte Homeostasis session Tuesday @ 12:30 in Room 320! #AAI2025 @aai.org

I'm presenting my research investigating multi-omic profiles and functional characteristics of human antibody-secreting cells at the Lymphocyte Homeostasis Block Symposium Tuesday at 12:30. If you love high-dimensional analyses, human immunology, and good old-fashioned benchtop experiments, stop by!