This work was co-led by my wife, Marla Glass! Thanks to everyone who contributed to this work, including my PI @evnewell.bsky.social, and our institutes, the @alleninstitute.org and the @fredhutch.org!
Evan Newell
@evnewell.bsky.social
Cellular Immunologist especially interested in analyzing antigen-specific T cells. Professor at Fred Hutchinson Cancer Center in Seattle.
A study from the lab of @evnewell.bsky.social looks at the immune response to multiple myeloma. It turned out the most interesting thing was what they didn’t find: T cells that had already recognized and tried to fight off tumor cells. Read more: pubmed.ncbi.nlm.nih.gov/40163891/
Our collaborator @evnewell.bsky.social + others outline a new approach to identifying tumor-infiltrating #immune cells from spatial #transcriptomics. They explore cell segmentation methods . @nature.com @hutchinnovation.bsky.social #ImmuneSky www.nature.com/articles/s41...
Cell simulation as cell segmentation - Nature Methods
Proseg is a segmentation approach for single-cell spatially resolved transcriptomics data that uses unsupervised probabilistic modeling of the spatial distribution of transcripts to accurately segment...
nature.com
Excited to share work from our team, released today. Check out how it compares to other methods on multiple platform's datasets. Would love to hear how it performs on your data. www.nature.com/articles/s41...
Cell simulation as cell segmentation - Nature Methods
Proseg is a segmentation approach for single-cell spatially resolved transcriptomics data that uses unsupervised probabilistic modeling of the spatial distribution of transcripts to accurately segment...
nature.com
New independent single cell benchmarking study by the @fredhutch.bsky.social innovation lab. Check it out! www.biorxiv.org/content/10.1...
biorxiv.org
Phenotype and function of IL-10–producing NK cells in individuals with malaria experience @jci-insight.bsky.social insight.jci.org/articles/vie...
FHIL loves working with the Srivastava Lab! Their work explores factors enabling CAR-T response to checkpoint blockade in solid tumors. Infiltration of CAR-Ts was assessed spatially with a Xenium custom panel including probes targeting the construct and lung tumor. www.biorxiv.org/content/10.1...
biorxiv.org
Excited to share my graduate work from the @ejohnwherry.bsky.social lab on the molecular mechanisms locking in the differentiation fate of exhausted CD8 T cells (Tex), published earlier this month in @science.org immunology. Main findings below! www.science.org/doi/10.1126/...
Continuous expression of TOX safeguards exhausted CD8 T cell epigenetic fate
TOX safeguards exhaustion biology in established Tex cells and restrains fate conversion to Teff cells.
science.org
Happy to share our new collaborative work! 🚨 We analyzed 2250 TCR repertoires to uncover how HLA risk alleles shape immune autoreactivity in T1D. T1D-specific HLA-motifs were also validated in pancreatic lymph nodes (pLN) & spleen. 🧬🧵 #T1D #Immunology #TCR 1/9
Sharing again for new followers - check out this fully-funded postdoc to work with any Fred Hutch comp bio faculty members! Pre-apps due Dec 20 to start next year! www.fredhutch.org/en/research/...
Mahan Fellowship
Fred Hutch is dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. As part of that goal, we offer the Mahan postdoctoral fellow...
fredhutch.org
Alison Feder@alisonfeder.bsky.social · 2y agoAre you a comp bio graduate student close to finishing your PhD? The Mahan Fellowship is a fully-funded ~2 year postdoc to work with any Fred Hutch comp bio faculty members! Pre-proposals are due Dec 20! Check out full details here: apply.interfolio.com/157470 #ScienceJobs 🧪 #AcademicSky
NiCo is out! Our new algorithm for spatial transcriptomics data analysis predicts the crosstalk of cell types co-localized in tissue niches and sheds light on signalling mediators and downstream effects of cell-cell interactions by inferring covarying gene programs. www.nature.com/articles/s41...
